Results 31 to 40 of about 324,320 (238)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Bulanık Mantık Tabanlı – Uzaktan Erişimli Sera Otomasyonu

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2016
Bu çalışmada endüstriyel denetim sistemlerinde yaygın olarak kullanılan PLC (Programlanabilir Mantık Denetleyicisi) ile bir sera sistemi kontrolü gerçekleştirilmiştir.
Mustafa Ayan, Ramazan Şenol
doaj  

Harnessing Vehicle-to-Vehicle Communications for 3G Downloads on the Move

International Journal of Distributed Sensor Networks, 2014
This paper studies the problem of 3G downloads in vehicles on the move. Although the 3G brings larger coverage and instant access to data transfer, it may also incur high cost. We observe that many applications of vehicular 3G users can actually tolerate
Yanmin Zhu, Qinghua Chen, Chao Chen
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Measurements of the E-mode polarization and temperature-E-mode correlation of the CMB from SPT-3G 2018 data

, 2021
International audienceWe present measurements of the E-mode (EE) polarization power spectrum and temperature-E-mode (TE) cross-power spectrum of the cosmic microwave background using data collected by SPT-3G, the latest instrument installed on the South ...
Cecil, TW, Ruhl, JE, Harrington, N.L., Michalik, D., Ding, J., Nguyen, H, Korman, M., Bleem, L.E., Kuo, C.-L., Harke-Hosemann, AH, Kubik, DL, Korman, M, Jeong, OB, Wu, W.L.K., Fu, J, Benabed, K., Prabhu, K., Howe, D, Pan, Z., Paschos, P., Raghunathan, S., Crawford, T.M., Bryant, L., Archipley, M., Jeong, O.B., Chang, C.L., Carter, F.W., Cliche, J.-F., Bender, AN, Rouble, M., Young, M.R., Reichardt, CL, Bouchet, FR, Ferguson, KR, Lowitz, AE, Harrington, NL, Denison, E.V., Guns, S., Story, K.T., Feng, C., Galli, S., Suzuki, A., Galli, S, Guyser, R., Ahmed, Z, Thakur, R. Basu, Knox, L, Omori, Y, Quan, W, Pearson, J, Guyser, R, Irwin, KD, Rahlin, A, Anderson, A.J., De Haan, T, Benson, B.A., Balkenhol, L, Avva, JS, Lee, A.T., Novosad, V., Bleem, LE, Khaire, TS, Sayre, JT, Bender, A.N., Smecher, G., de Haan, T., Hilton, G.C., Gardner, R.W., Goeckner-Wald, N., Natoli, T., Crawford, TM, Tucker, C., Carlstrom, J.E., Anderes, E, Kofman, A.M., Gambrel, AE, Cukierman, A, Carter, FW, Lee, AT, Nadolski, A., Cliche, JF, Leitch, E.M., Foster, A, Hood, JC, Cecil, T.W., Hilton, GC, Foster, A., Sayre, J.T., Ade, P.A.R., Holder, GP, Holzapfel, W.L., Guns, S, Benabed, K, Cho, HM, Irwin, K.D., Cho, H.-M., Rouble, M, Nadolski, A, Everett, W, Huang, N., Feng, C, Huang, N, Fu, J., Natoli, T, Jones, A., Holder, G.P., Dobbs, M.A., Khaire, T.S., Daley, C, Reichardt, C.L., Daley, C., Stark, A.A., Raghunathan, S, Umilta, C., Holzapfel, WL, Bouchet, F.R., Chou, T.-L., Nguyen, H., Montgomery, J, Dobbs, MA, Rahlin, A., Posada, C.M., Kubik, D.L., Kuhlmann, S., Paschos, P, Dutcher, D., Barry, PS, Gualtieri, R, Anderes, E., Cukierman, A., Michalik, D, Dibert, K., Quan, W., Thompson, K.L., Yoon, K.W., Henning, JW, Anderson, AJ, Montgomery, J., Prabhu, K, Stephen, J., Sobrin, J.A., Howe, D., Everett, W., Riedel, B, Goeckner-Wald, N, Harke-Hosemann, A.H., Hivon, E., Jonas, M., Lowitz, A.E., Gupta, N., Noble, G.I., Barry, P.S., Lu, C, Thorne, B., Bianchini, F., Denison, EV, Chaubal, P., Padin, S., Shirokoff, E., Knox, L., Henning, J.W., Chang, CL, Balkenhol, L., Riebel, D, Kuhlmann, S, Millea, M, Aylor, K., Aylor, K, Vale, L.R., Whitehorn, N., Avva, J.S., Omori, Y., Vieira, J.D., Halverson, N.W., Dibert, K, Meyer, S.S., Gupta, N, Jones, A, Bianchini, F, Ade, PAR, Chaubal, P, Leitch, EM, Byrum, K., Noble, GI, Padin, S, Millea, M., Riedel, B., Kofman, AM, Halverson, NW, Pan, Z, Riebel, D., Kuo, CL, Novosad, V, Byrum, K, Hivon, E, Ade, P. A. R., Benson, BA, Vanderlinde, K., Archipley, M, Basu Thakur, R., Chen, G., Posada, CM, Bryant, L, Lu, C., Chen, G, Wang, G., Ruhl, J.E., Ding, J, Barry, Peter, Ferguson, K.R., Yefremenko, V., Dutcher, D, Meyer, SS, Chou, TL, Jonas, M, Schiappucci, E., Pearson, J., Gardner, RW, Gualtieri, R., Ahmed, Z., Carlstrom, JE, Gambrel, A.E., Hood, J.C., Basu Thakur, R, S. Kuhlmann, L. Balkenhol, L. Knox, B. Riedel, G. Smecher, H.-M. Cho, C. L. Chang, A. M. Kofman, D. Riebel, V. Yefremenko, M. A. Dobbs, S. Padin, A. Suzuki, A. Jones, J. A. Sobrin, N. L. Harrington, K. Dibert, M. Rouble, O. B. Jeong, null null, N. Gupta, T. Natoli, A. N. Bender, J. Pearson, J. E. Ruhl, C. Lu, D. Michalik, J. C. Hood, K. Aylor, M. Millea, K. Benabed, L. E. Bleem, E. Hivon, J. T. Sayre, J. Ding, K. W. Yoon, A. A. Stark, A. H. Harke-Hosemann, C. L. Reichardt, A. T. Lee, L. R. Vale, J. S. Avva, R. Basu Thakur, J. D. Vieira, C. Umilta, A. Cukierman, M. Korman, W. L. K. Wu, P. A. R. Ade, M. Jonas, A. Foster, V. Novosad, M. R. Young, A. J. Anderson, A. Nadolski, Z. Ahmed, F. W. Carter, Y. Omori, P. S. Barry, J. Montgomery, T.-L. Chou, L. Bryant, S. Guns, J. W. Henning, P. Chaubal, R. Guyser, C. Feng, P. Paschos, N. Goeckner-Wald, D. Dutcher, C.-L. Kuo, E. M. Leitch, S. S. Meyer, J. Fu, K. Vanderlinde, H. Nguyen, K. Byrum, Z. Pan, B. A. Benson, J.-F. Cliche, A. E. Gambrel, E. V. Denison, A. Rahlin, R. Gualtieri, G. C. Hilton, E. Shirokoff, W. L. Holzapfel, G. P. Holder, S. Raghunathan, E. Schiappucci, G. Wang, C. Daley, N. W. Halverson, G. Chen, S. Galli, W. Quan, K. D. Irwin, T. S. Khaire, D. Howe, K. T. Story, W. Everett, E. Anderes, K. R. Ferguson, T. W. Cecil, J. Stephen, R. W. Gardner, K. L. Thompson, G. I. Noble, C. Tucker, D. L. Kubik, B. Thorne, T. de Haan, A. E. Lowitz, K. Prabhu, T. M. Crawford, N. Huang, N. Whitehorn, J. E. Carlstrom, M. Archipley, F. R. Bouchet, C. M. Posada, F. Bianchini   +345 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

4G: Expectativas, Aplicaciones y Retos Existentes en su Implementación

Prisma Tecnológico, 2016
Cada vez son mayores los requerimientos de los sistemas inalámbricos por la creciente necesidad de información diversa por parte de los usuarios. Nos encontramos actualmente en le punto de transición entre una generación de tecnología y otra. Y si bien
Francisco Tello
doaj  

Contamination of Wheat Cultivated in Various Regions of Poland during 2017 and 2018 Agricultural Seasons with Selected Trichothecenes and Their Modified Forms

Toxins, 2019
Cross-interaction of antibodies within the immunoaffinity columns used in this study facilitated the simultaneous determination of nivalenol (NIV), deoxynivalenol (DON), their glucoside derivatives (NIV-3G, DON-3G), and 3-acetyl-deoxynivalenol (3-AcDON ...
Marcin Bryła, Edyta Ksieniewicz-Woźniak, Tomoya Yoshinari, Agnieszka Waśkiewicz, Krystyna Szymczyk   +4 more
doaj   +1 more source