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In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase

open access: yesArabian Journal of Chemistry, 2017
AbstractReduced levels of γ-aminobutyric acid (GABA) are cause of quite a many diseases, and it cannot be directly introduced into the body to enhance its level because of the blood–brain barrier. Thus the technique used for the purpose involves the inhibition of aminobutyrate transaminase (ABAT), the enzyme catalyzing its degradation. The structure of
Sidra Batool   +2 more
exaly   +2 more sources

Intramitochondrial localization of the 4-aminobutyrate-2-oxoglutarate transaminase from ox brain [PDF]

open access: yesBiochemical Journal, 1977
In order to determne the intramitochondrial location of 4-aminobutyrate transaminase, mitochondria were prepared from ox brain and freed from myelin and synaptosomes by using conventional density-gradient-centrifugation techniques, and the purity was checked electron-microscopically.
Arne Schousboe, Schousboe A
exaly   +3 more sources

Pig brain 4-aminobutyrate 2-ketoglutarate transaminase. Purification, kinetics and physical properties

Biochimie, 1974
Summary Pig brain 4-aminobutyrate 2-ketoglutarate transaminase, (E.C. 2.6.1.19) has been purified about 1200 to 1500 fold, using ammonium sulfate fractionation, heat precipitation and various chromatographic techniques. The enzyme was homogeneous in polyacrylamide gel electrophoresis and appeared as a dimer when electrophoresis was performed in ...
P Gonnard
exaly   +5 more sources

A single transaminase for 1,4-diaminobutane and 4-aminobutyrate in a pseudomonas species

Biochemical and Biophysical Research Communications, 1971
Abstract A Pseudomonas species uses a single transaminase to catalyze the transamination of 1,4-diaminobutane and 4-aminobutyrate.
T T Tchen
exaly   +3 more sources

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