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4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity
Bioorganic & Medicinal Chemistry Letters, 2008Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase.
SCIPIONE, Luigi +5 more
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4-Aminopyridine Potentiates Neostigmine and Pyridostigmine in Man
Anesthesiology, 1979To elucidate the interaction of 4-aminopyridine with neostigmine and pyridostigmine, the authors studied 57 anesthetized surgical patients using a technique of constant infusion of pancuronium to quantitate antagonist activity. 4-Aminopyridine, 0.15 or 0.35 mg/kg, produced no antagonism, while 0.5 mg/kg produced a mean 24 +/- 6 per cent (peak ...
Miller, RD +3 more
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A new calorimetric standard: 4-aminopyridine
Thermochimica Acta, 1977Abstract The need for a new solution calorimetric standard is discussed. The standard proposed is 4-aminopyridine which is shown to be more satisfactory than the previously accepted standards of sodium hydroxide or trishydroxyaminomethane. The reaction is HClO 4 (aq) + 4–AP(aq)→4–APH + ClO − 4 (aq) with Δ H ° N (298.15 K) =11.164±0.011 kcal mol −1 .
Alan E. Van Til, Dennis C. Johnson
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Effects of 4-aminopyridine on neuromuscular transmission
Brain Research, 19784-Aminopyridine (4-AP) powerfully increases transmitter release from motor nerve terminals of rat and frog skeletal muscle in response to single nerve impulses. The drug also enhances transmitter release during repetitive nerve activity but, at D-tubocurarine-blocked endplates, only the first impulses cause increased transmitter release at stimulation ...
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Degradation of 4-aminopyridine in soil
Journal of Agricultural and Food Chemistry, 1976P M, Betts, C W, Giddings, J R, Fleeker
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ChemInform Abstract: INDO THEORETICAL STUDIES OF 4‐AMINOPYRIDINE AND PROTONATED 4‐AMINOPYRIDINE
Chemischer Informationsdienst, 1976CHARLES U. JUN. PITTMAN +2 more
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