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2000
Abstract Aminopyridines block voltage-activated potassium channels, thereby increasing action potential duration (6) and neurotransmitter release. They have been used with moderate success in the treatment of multiple sclerosis (4, 17) and Lambert-Eaton myasthenic syndrome (15).
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Abstract Aminopyridines block voltage-activated potassium channels, thereby increasing action potential duration (6) and neurotransmitter release. They have been used with moderate success in the treatment of multiple sclerosis (4, 17) and Lambert-Eaton myasthenic syndrome (15).
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The Use of Aminopyridines in Neurological Disorders
Clinical Neuropharmacology, 2012Aminopyridines are members of a family of monoamino and diamino derivatives of pyridine, and their principal mechanism of action is dose-dependent blockade of voltage-gated potassium channels, in particular, fast voltage-gated potassium channels.
Saam, Sedehizadeh +2 more
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Acta Crystallographica Section C Crystal Structure Communications, 2002
The title compound, C(5)H(6)N(2)S, is a simple but novel pyridinethiol of pharmacological interest. The molecule is planar. The crystal packing is dominated by hydrophobic contacts and a pair of hydrogen-bond interactions between the amino group of one pyridine molecule and the ring N atom of a neighbouring base, stabilizing the structure.
J R, Sabino +2 more
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The title compound, C(5)H(6)N(2)S, is a simple but novel pyridinethiol of pharmacological interest. The molecule is planar. The crystal packing is dominated by hydrophobic contacts and a pair of hydrogen-bond interactions between the amino group of one pyridine molecule and the ring N atom of a neighbouring base, stabilizing the structure.
J R, Sabino +2 more
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Interaction of antidepressants with 4-aminopyridine
Life Sciences, 1992Systemic administration of 4-Aminopyridine at a dose of 4 mg/kg (4-AP) induces hypothermia in mice. Scopolamine (ED50 = 0.26 mg/kg) and two tricyclic antidepressants, desipramine (ED50 = 1.82 mg/kg) and IM/P/3/4 (ED50 = 8.95 mg/kg) completely antagonize 4-AP-induced hypothermia, whereas minaprine (0.1-0.25 mg/kg), a non-tricyclic antidepressant ...
G, Volterra, A, Lecci
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Adsorption of aminopyridines to phosphatidylserine membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1990Aminopyridines belong to the class of compounds which facilitate synaptic transmission at low calcium concentration, an effect associated with the block of K+ channels, enhanced entry of calcium into presynaptic terminals and greater release of transmitter.
P, Smejtek +3 more
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INDO theoretical studies of 4-aminopyridine and protonated 4-aminopyridine
Journal of the Chemical Society, Perkin Transactions 2, 1975Geometry optimized INDO calculations have been performed on 4-aminopyridine (2) and protonated 4-aminopyridine (1) in order to compare their optimized geometries, π-bond orders, C(4)–NH2 rotational barriers, charge densities, and π-electron distributions. It had previously been shown that 4-aminopyridine falls far off a linear correlation of ΔG° and ΔS°
Charles U. Pittman +2 more
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Pharmacokinetics of 4-aminopyridine in cattle
American Journal of Veterinary Research, 1984SUMMARY Concentrations of 4-aminopyridine hydrochloride in plasma of cattle were measured over an 8-hour period following a bolus IV injection (0.3 mg/kg). The drug was assayed by a gas-liquid chromatographic method using a nitrogen-phosphorus detector.
J V, Kitzman +5 more
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Angewandte Chemie International Edition in English, 1980
Werner Jünemann +2 more
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Werner Jünemann +2 more
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2-Aminopyridine and 3-aminopyridine. Errata
Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, 1976M. Chao, E. Schempp, R. D. Rosenstein
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