Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen. [PDF]
, 2016 Pyrido[1,2-a]pyrimidin-2-ones represent a pharmaceutically interesting class of heterocycles. The structurally related pyrido[1,2-a]pyrimidin-4-ones are associated with a broad range of useful biological properties.
Alanine, TA +5 more
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Results in Chemistry, 2023 Imidazo[1,2-a]pyridines belong to a class of heterocyclic motifs possessing unique structural and pharmacological properties making them an interesting and promising domain in the fields of drug discovery and medicinal chemistry.
Mohan Neetha +2 more
doaj +1 more source
Halogenation of pyridinium-N-(2'-pyridyl)aminide: an easy synthesis of halo-2-aminopyridines [PDF]
, 1995 The regioselective halogenatmn of pyrldmium-N-(2’-pyridyljaminide 1 with N-chloro,\ud bromo or iodosuccinimtde under mild conditions IS described. The method, combined with a\ud reductmn of the N-N bond, allows an easy preparation of 5-h& and 3,5-dihalo ...
Burgos García, Carolina +4 more
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The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
Molecules, 2003 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga +4 more
doaj +1 more source
Presynaptic facilitation at the crayfish neuromuscular junction: Role of calcium-activated potassium conductance [PDF]
, 1991 Membrane potential was recorded intracellularly near presynaptic terminals of the excitor axon of the crayfish opener neuromuscular junction (NMJ), while transmitter release was recorded postsynaptically.
Bittner, George D. +2 more
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Template-directed synthesis of macrocyclic aminopyridines: azacalix[n](2,6)pyridines (n = 3, 4) [PDF]
, 2014 Template-induced synthetic routes for azacalix[n](2,6)pyridines (n = 3, 4) have been elaborated. The proton and nickel ion served as the efficient template for the cyclization reactions, and the presence of the templates preferentially afforded the ...
Kuwabara Junpei +5 more
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Microwave-assisted Bohlmann–Rahtz synthesis of highly-substituted 2-aminonicotinates [PDF]
, 2016 Microwave irradiation of 2-carbethoxyacetamidine and an ethynyl ketone under acidic or basic conditions in ethanol at 150 °C for 1.5 h facilitated Bohlmann-Rahtz pyridine synthesis to give highly-substituted ethyl 2 aminonicotinates with total ...
Alnomsy, Ayed +2 more
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Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines
Molecules, 2011 The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3-dithiazol-ium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-X-amines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized with respect to base ...
Panayiotis A. Koutentis +2 more
doaj +1 more source
Molecules, 2023 While fluorescent organic materials have many potential as well as proven applications and so have attracted significant attention, pyridine–olefin conjugates remain a less studied subset of such systems.
Weiguang Yang +5 more
doaj +1 more source
Cracking the code: the clinical and molecular impact of aminopyridines; a review (2019-2024). [PDF]
RSC AdvKhalid T +5 more
europepmc +3 more sources