Results 31 to 40 of about 10,137 (277)
Bulky-yet-flexible carbene ligands and their use in palladium cross-coupling [PDF]
, 2019 In recent years, several classes of new N-heterocyclic carbene (NHC) ligands were developed around the concept of flexible steric bulk. The steric hindrance of these ligands brings stability to the active species, while ligand flexibility still allows ...
Cazin, Catherine +2 more
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Improvement of diaphragm and limb muscle isotonic contractile performance by K+ channel blockade
Journal of NeuroEngineering and Rehabilitation, 2010 The K+ channel blocking aminopyridines greatly improve skeletal muscle isometric contractile performance during low to intermediate stimulation frequencies, making them potentially useful as inotropic agents for functional neuromuscular stimulation ...
Pollarine Jennifer, van Lunteren Erik
doaj +1 more source
Molecules, 2023 A facile, green, synthetic protocol of several substituted N-(pyridin-2-yl)imidates from nitrostyrenes and 2-aminopyridines via the corresponding N-(pyridin-2-yl)iminonitriles as intermediates is reported.
Andriani G. Chaidali, Ioannis N. Lykakis
doaj +1 more source
Scientific Reports, 2017 Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation.
Phillip H. Beske +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2022 Novel pyridine-based fluorescing compounds, viz. pyrido[1,2-a]pyrrolo[3,4-d]pyrimidines 3a,b and N-methyl-4-((pyridin-2-yl)amino)maleimides 4a–e, were selectively prepared by a one-pot reaction between a functionalized maleimide and 2-aminopyridines with
Masayori Hagimori +4 more
doaj +1 more source
Pyridine Elaboration through Organometallic Intermediates: Regiochemical Control and Completeness [PDF]
, 2007 International audiencePyridines carrying heterosubstituents (such as carboxy, amido, amino, alkoxy or trifluoromethyl groups or solely individual halogen atoms) can be readily and site selectively metalated.
Mongin, Florence, Schlosser, Manfred
core +4 more sources
Neuroprotective Properties of 4-Aminopyridine [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2021 As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used as symptomatic therapy in several neurologic disorders. The improvement of visual function and motor skills and relieve of fatigue in patients with MS have been attributed to 4-AP.
Dietrich, Michael +2 more
openaire +2 more sources
One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction
Beilstein Journal of Organic Chemistry, 2016 A novel three-component reaction has been developed to assemble biologically and pharmaceutically important tetracyclic fused imidazo[1,2-a]pyridines in a one-pot fashion utilizing readily available 2-aminopyridines, isatins and isocyanides.
Bo Yang +4 more
doaj +1 more source
4-Aminopyridine Improves Lower Urinary Tract Symptoms in a Patient With Benign Prostatic Hyperplasia and Downbeat Nystagmus Syndrome [PDF]
International Neurourology Journal, 2014 Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders.
Michael Strupp +3 more
doaj +1 more source
Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer’s disease [PDF]
, 2017 The authentic standards 2-(cyclopropanecarboxamido)-N-(4-methoxypyridin-3-yl)isonicotinamide (4a) and 2-(cyclopropanecarboxamido)-N-(4-(4-methoxyphenyl)pyridin-3-yl)isonicotinamide (7a), and their corresponding precursors 2-(cyclopropanecarboxamido)-N-(4-
Gao, Mingzhang +2 more
core +2 more sources