Results 31 to 40 of about 4,314 (231)

Synthesis and Regularities of the Structure–Activity Relationship in a Series of N-Pyridyl-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides

Scientia Pharmaceutica, 2019
According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-dioxo-1H-2&
Igor V. Ukrainets, Anna A. Burian, Ganna M. Hamza, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Kateryna O. Burian, Galina Sim   +8 more
doaj   +1 more source

An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

Beilstein Journal of Organic Chemistry, 2023
An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary
Shubham Sharma, Dharmender Singh, Sunit Kumar, Vaishali, Rahul Jamra, Naveen Banyal, Deepika, Chandi C. Malakar, Virender Singh   +8 more
doaj   +1 more source

Application of recyclable base-washed graphene oxide for one-pot conversion of 2-aminopyridines into 5-iodo-imidazo[1,2-a]pyridines at room temperature in water

Results in Chemistry, 2022
A green synthetic protocol for cyclization of 2-aminopyridines with 2-bromoacetophenones to prepare imidazo[1,2-a]pyridines, followed by its successive iodination in one-pot manner, employing base-washed graphene oxide as the catalyst, in water has been ...
Sumit Das, Bhagat Singh, Pulak Fadikar, Piyali Deb Barman, Rupankar Paira   +4 more
doaj   +1 more source

Synthesis of 3-aminoimidazo[1,2-a]pyridines via three-component reaction in the 2,2,2-trifluoroethanol-water two-phase systems [PDF]

شیمی کاربردی روز, 2020
An efficient synthesis of 3-aminoimidazo[1,2-a]pyridines via three-component reaction from aromatic aldehydes, 2-aminopyridines and isonitriles at room temperature in water/2,2,2-trifluoroethanol two-phase systems is described.
Mobina Alizade-Majd, Afshin Sarvary, Masoud Nahali   +2 more
doaj   +1 more source

Efficient electrochemical N-alkylation of N-boc-protected 4-aminopyridines: towards new biologically active compounds. [PDF]

, 2014
The use of electrogenerated acetonitrile anion allows the alkylation of N-Boc-4-aminopyridine in very high yields, under mild conditions and without by-products.
FEROCI, Marta, Maes, Louis, FORTE, GIANPIERO, SCIPIONE, Luigi, DI SANTO, Roberto, CHIAROTTO, Isabella, Diodata, FRIGGERI, LAURA, TORTORELLA, Silvano, SIMONETTI, Giovanna, D'AURIA, Felicia Diodata, DE VITA, DANIELA   +11 more
core   +2 more sources

Antagonism of non-depolarising neuromuscular blockade by aminopyridines in cats [PDF]

, 1986
The antagonism of pipecuronium- and vecuronium-induced neuromuscular blockade by 4-aminopyridine (4AP), 3,4-diaminopyridine (3,4AP) and 3-[(dimethylamino)-carbonyl] amino-4-aminopyridine (LF14) were studied in anaesthetized cats during constant infusion ...
Egon Kápáti, Miklos Riesz, László Szporny   +2 more
core   +1 more source

Synthesis of imidazo[1,2-a]pyridine derivatives and Zolimidine via a novel zinc/iodine-catalyzed Ortoleva-King type protocol

Results in Chemistry, 2023
Imidazo[1,2-a]pyridines belong to a class of heterocyclic motifs possessing unique structural and pharmacological properties making them an interesting and promising domain in the fields of drug discovery and medicinal chemistry.
Mohan Neetha, Elsa Biya, Gopinathan Anilkumar   +2 more
doaj   +1 more source

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

Molecules, 2003
3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga, Yasuo Tohda, Kazushige Hori, Mina Tamura, Nagatoshi Nishiwaki   +4 more
doaj   +1 more source

The effect of some new aminopyridines on mammalian non-myelinated nerve fibres [PDF]

, 1983
We evaluated the action of 2,4-, 3,4-diaminopyridine and 3-[(dimethylamino)carbonyl]amino,4-aminopyridine (LF-14) on non-myelinated fibres of the guinea-pig vagus nerve.
den Hertog, A, Biessels, P, Agoston, S, Pielkenrood, J, DENHERTOG, A   +4 more
core   +1 more source

A Facile N-monoalkylation of Aminopyridines [PDF]

, 2011
The N-monoalkylation of 2- or 3-aminopyridines by a carboxylic acid and sodium borohydride afforded the corresponding alkylaminopyridine under mild conditions in good yields.
Dongmei Li, Zhongzhen Tian, Zhong Li, Zhaoxing Jiang   +3 more
core   +1 more source