Results 31 to 40 of about 7,735 (236)

Simple Synthetic Approach to N-(Pyridin-2-yl)imidates from Nitrostyrenes and 2-Aminopyridines via the N-(Pyridin-2-yl)iminonitriles as Intermediates

Molecules, 2023
A facile, green, synthetic protocol of several substituted N-(pyridin-2-yl)imidates from nitrostyrenes and 2-aminopyridines via the corresponding N-(pyridin-2-yl)iminonitriles as intermediates is reported.
Andriani G. Chaidali, Ioannis N. Lykakis
doaj   +1 more source

Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A

Scientific Reports, 2017
Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation.
Phillip H. Beske, Katie M. Hoffman, James B. Machamer, Margaret R. Eisen, Patrick M. McNutt   +4 more
doaj   +1 more source

Syntheses of novel pyridine-based low-molecular-weight luminogens possessing aggregation-induced emission enhancement (AIEE) properties

Beilstein Journal of Organic Chemistry, 2022
Novel pyridine-based fluorescing compounds, viz. pyrido[1,2-a]pyrrolo[3,4-d]pyrimidines 3a,b and N-methyl-4-((pyridin-2-yl)amino)maleimides 4a–e, were selectively prepared by a one-pot reaction between a functionalized maleimide and 2-aminopyridines with
Masayori Hagimori, Tatsusada Yoshida, Yasuhisa Nishimura, Yukiko Ogawa, Keitaro Tanaka   +4 more
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One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction

Beilstein Journal of Organic Chemistry, 2016
A novel three-component reaction has been developed to assemble biologically and pharmaceutically important tetracyclic fused imidazo[1,2-a]pyridines in a one-pot fashion utilizing readily available 2-aminopyridines, isatins and isocyanides.
Bo Yang, Chuanye Tao, Taofeng Shao, Jianxian Gong, Chao Che   +4 more
doaj   +1 more source

4-Aminopyridine Improves Lower Urinary Tract Symptoms in a Patient With Benign Prostatic Hyperplasia and Downbeat Nystagmus Syndrome [PDF]

International Neurourology Journal, 2014
Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders.
Michael Strupp, Katharina Feil, Stanislavs Bardins, Raphaela Waidelich   +3 more
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An Improved Synthesis of 4-Chlorocoumarin-3-sulfonyl Chloride and Its Reactions with Different Bidentate Nucleophiles to Give Pyrido[1',2':2,3]- and Thiazino[3',2':2,3]-1,2,4-Thiadiazino[6,5-c]Benzopyran-6-one 7,7-Dioxides

Molecules, 2007
An improved synthetic method affording 4-chlorocoumarin-3-sulfonyl chloride (4) in very good yield (ca. 85 %) is reported. This compound was reacted with various bidentate nucleophiles such as 2-aminopyridines and 2-aminothiazoles in order to obtain ...
Emil Popovski, Gerald Draeger, Bozhana Mikhova, Evamarie Hey-Hawkins, Ahmed Jashari   +4 more
doaj   +1 more source

An Efficient Synthesis of Novel 3-[(Heteroaryl-2-ylimino)-methyl]-4-hydroxy-chromen-2-ones and Analogue of Tetrazole Derivatives and Their Antibacterial Activity

Molbank, 2021
Synthesis of a series of the substituted [(pyridinyl and pyrimidin-2-ylimino)-ethyl]-4-hydroxy-chromen-2-ones and their tetrazole derivates is presented in this study. By catalytic condensation of 4-hydroxy-3-acetylcoumarine 2 and 2-aminopyridines 3(a-d),
Ramiz Hoti, Hamit Ismaili, Veprim Thaçi, Gjyle Mulliqi-Osmani, Malësore Pllana-Zeqiri, Agon Bytyqi   +5 more
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Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains

Beilstein Journal of Organic Chemistry, 2017
Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines.
Layal Hariss, Kamal Bou Hadir, Mirvat El-Masri, Thierry Roisnel, René Grée, Ali Hachem   +5 more
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Flow Hydrodediazoniation of Aromatic Heterocycles

Molecules, 2019
Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment
Liesa Röder, Alexander J. Nicholls, Ian R. Baxendale   +2 more
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The Reaction of 2-Aminopyridines with Ethyl Diazoacetate

CHIMIA, 1974
It has been found that ethyl diazoacetate reacted with 2- amino-pyridines to give the corresponding 2-carbethoxy- methylaminopyridines (1). In m-xylene as solvent, thermal decomposition of the diazo ester proceeded with preferential attack on m-xylene ...
B. Doma, B. Verček, B. Stanovnik, M. Tišler   +3 more
doaj   +1 more source