Results 1 to 10 of about 8,587 (262)
Frontiers in Immunology, 2022 IntroductionThe adverse effects of neuromuscular junction dysfunctions caused by immune checkpoint inhibitor (ICI) drugs have not been thoroughly assessed in the clinics.ObjectiveTo assess the neuromuscular junction dysfunctions in cancer patients with ...
Ping Zhang +10 more
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The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. [PDF]
PLoS ONE, 2012 The neuromuscular junctions are the specialized synapses whereby spinal motor neurons control the contraction of skeletal muscles. The formation of the neuromuscular junctions is controlled by a complex interplay of multiple mechanisms coordinately ...
Emilie Audouard +7 more
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Myasthenia gravis in clinical practice
Arquivos de Neuro-Psiquiatria, 2022 Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease.
Eduardo de Paula Estephan +2 more
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Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice
Nature Communications, 2022 The group of Shih-Yin Tsai observed age-associated neuromuscular junction structural instability in male but not female mice which is driven by dysregulation of mTOR complex 1 activity. Genetic activation of the downstream phosphorylation target 4EBP1 in
Seok-Ting J. Ang +10 more
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Biology, 2023 Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago +13 more
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Plum modulates Myoglianin and regulates synaptic function in D. melanogaster
Open Biology, 2023 Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function.
Virender K. Sahota +6 more
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Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration
eLife, 2017 Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response ...
Wenxuan Liu +10 more
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Chronic aryl hydrocarbon receptor activity phenocopies smoking‐induced skeletal muscle impairment
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Chronic obstructive pulmonary disease (COPD) patients exhibit skeletal muscle atrophy, denervation, and reduced mitochondrial oxidative capacity.
Trace Thome +15 more
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Neural Regeneration Research, 2021 Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the ...
Francisco J Barrantes
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Denervation-Related Neuromuscular Junction Changes: From Degeneration to Regeneration
Frontiers in Molecular Neuroscience, 2022 Neuromuscular junctions (NMJs) are the key interface between terminal nerves and targeted muscle, which undergo degeneration during denervation periods. Denervation-related NMJs changes limits the recovery level of nerve repair strategies.
Xinying Huang +9 more
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