Human in vitro neuromuscular junction model to functionally dissect the pathogenic mechanism of anti-AChR autoantibody-positive myasthenia gravis [PDF]
BMC Pharmacology and ToxicologyBackground Myasthenia gravis is a rare autoimmune disease mediated by autoantibodies directed against acetylcholine receptors (AChRs) at the neuromuscular junction.
Baehyun Shin +7 more
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Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration [PDF]
eLife, 2017 Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response ...
Wenxuan Liu +10 more
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Nanotube-Assisted Motor Neuron and Neuromuscular Junction Stabilization in Spinal Muscular Atrophy: A Hypothesis for Adjunctive Therapy [PDF]
Neurology InternationalSpinal muscular atrophy (SMA) therapies that restore SMN expression improve survival and motor function but often fail to fully stabilize distal motor units or sustain endurance.
Almir Fajkić +8 more
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A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis [PDF]
npj Systems Biology and ApplicationsA molecular systems architecture is presented for the neuromuscular junction (NMJ) in order to provide a framework for organizing complexity of biomolecular interactions in amyotrophic lateral sclerosis (ALS) using a systematic literature review process.
V. A. Shiva Ayyadurai +2 more
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Frontiers in Immunology, 2022 IntroductionThe adverse effects of neuromuscular junction dysfunctions caused by immune checkpoint inhibitor (ICI) drugs have not been thoroughly assessed in the clinics.ObjectiveTo assess the neuromuscular junction dysfunctions in cancer patients with ...
Ping Zhang +10 more
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The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. [PDF]
PLoS ONE, 2012 The neuromuscular junctions are the specialized synapses whereby spinal motor neurons control the contraction of skeletal muscles. The formation of the neuromuscular junctions is controlled by a complex interplay of multiple mechanisms coordinately ...
Emilie Audouard +7 more
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Myasthenia gravis in clinical practice
Arquivos de Neuro-Psiquiatria, 2022 Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease.
Eduardo de Paula Estephan +2 more
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Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice
Nature Communications, 2022 The group of Shih-Yin Tsai observed age-associated neuromuscular junction structural instability in male but not female mice which is driven by dysregulation of mTOR complex 1 activity. Genetic activation of the downstream phosphorylation target 4EBP1 in
Seok-Ting J. Ang +10 more
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Biology, 2023 Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago +13 more
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Plum modulates Myoglianin and regulates synaptic function in D. melanogaster
Open Biology, 2023 Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function.
Virender K. Sahota +6 more
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