Results 31 to 40 of about 59,298 (301)

Reconstruction of the neuromuscular junction connectome [PDF]

Bioinformatics, 2010
Abstract Motivation: Unraveling the structure and behavior of the brain and central nervous system (CNS) has always been a major goal of neuroscience. Understanding the wiring diagrams of the neuromuscular junction connectomes (full connectivity of nervous system neuronal components) is a starting point for this, as it helps in the study
Ranga Srinivasan, Qing Li 0008, Xiaobo Zhou 0001, Ju Lu, Jeff Lichtman, Stephen T. C. Wong   +5 more
openaire   +4 more sources

Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging

Cells, 2020
Skeletal muscle deteriorates with aging, contributing to physical frailty, poor health outcomes, and increased risk of mortality. Denervation is a major driver of changes in aging muscle.
Maria-Eleni Anagnostou, Russell T. Hepple   +1 more
doaj   +1 more source

Measuring Neuromuscular Junction Functionality [PDF]

Journal of Visualized Experiments, 2017
Neuromuscular junction (NMJ) functionality plays a pivotal role when studying diseases in which the communication between motor neuron and muscle is impaired, such as aging and amyotrophic lateral sclerosis (ALS). Here we describe an experimental protocol that can be used to measure NMJ functionality by combining two types of electrical stimulation ...
Rizzuto, Emanuele, Pisu, Simona, Nicoletti, Carmine, Del Prete, Zaccaria, Musaro, Antonio   +4 more
openaire   +2 more sources

Synaptic bouton sizes are tuned to best fit their physiological performances : poster presentation from Twentieth Annual Computational Neuroscience Meeting: CNS*2011, Stockholm, Sweden, 23 - 28 July 2011 [PDF]

, 2011
Poster presentation from Twentieth Annual Computational Neuroscience Meeting: CNS*2011 Stockholm, Sweden. 23-28 July 2011. To truly appreciate the myriad of events which relate synaptic function and vesicle dynamics, simulations should be done in a ...
Markus Knodel, Dan Bucher, Alfio Grillo, Christoph Schuster, Bucher, Dan, Geiger, Romina, Ge, Lee How, Grillo, Alfio, Knodel, Markus Michael, Queisser, Sean Gillian, Romina Geiger, Lee How Ge, Gillian Queisser, Schuster, Christoph M., Wittum, Gabriel, Gabriel Wittum, Lee Ge   +16 more
core   +1 more source

Terminal Schwann cells at the human neuromuscular junction [PDF]

, 2021
Terminal Schwann cells are non-myelinating glial cells localized to the neuromuscular junction. They play an important role in regulating many aspects of neuromuscular junction form and function, in health and during disease. However, almost all previous
Alhindi, Abrar, Jones, Ross A, Gillingwater, Thomas H, Forsythe, Rachael O, Skipworth, Richard J E, Simpson, Hamish, Boehm, Ines, Miller, Janice   +7 more
core   +1 more source

Internalization of Muscle-Specific Kinase Is Increased by Agrin and Independent of Kinase-Activity, Lrp4 and Dynamin

Frontiers in Molecular Neuroscience, 2022
Muscle-specific kinase (MuSK) is a receptor tyrosine kinase absolutely required for neuromuscular junction formation. MuSK is activated by binding of motor neuron-derived Agrin to low-density lipoprotein receptor related protein 4 (Lrp4), which forms a ...
Anna Gemza, Cinzia Barresi, Jakob Proemer, Jasmin Hatami, Margarita Lazaridis, Ruth Herbst   +5 more
doaj   +1 more source

Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

Neurobiology of Disease, 2019
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure.
Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton   +20 more
doaj   +1 more source

Functional characterization of MuSK, receptor tyrosine kinase required for the formation and the maintenance of nerve-muscle synapses : "in vivo" and "in vitro" approaches [PDF]

, 2008
The developing neuromuscular junction (NMJ) serves as one of the best model systems for studying synapse formation since changes in shape, size, and molecular composition can be followed with high spatial and temporal resolution.
Maj, Marcin
core   +1 more source

Synaptic boutons sizes are tuned to best fit their physiological performances [PDF]

, 2013
To truly appreciate the myriad of events which relate synaptic function and vesicle dynamics, simulations should be done in a spatially realistic environment. This holds true in particular in order to explain as well the rather astonishing motor patterns
Dan Bucher, Alfio Grillo, Christoph Schuster, Bucher, Dan, Geiger, Romina, Grillo, Alfio, Lihao Ge, Knodel, Markus Michael, Queisser, Sean Gillian, Markus M Knodel, Romina Geiger, Ge, Lihao, Gillian Queisser, Schuster, Christoph M., Wittum, Gabriel, Gabriel Wittum   +15 more
core   +1 more source

Classification of Neuromuscular Junction and Tendon Recordings of Neuromuscular Diseases by Their Spectrogram [PDF]

, 2021
In this study, the effect of spectrograms from neuromuscular junction and tendon records for normal, neurogenic and myopathic motor units being constructed via EMG Simulator v3.6 on the differential diagnosis were investigated.
Baslo, Baris, Artug, Tugrul, Osman, Onur, Goker, Imran   +3 more
core   +1 more source