Results 21 to 30 of about 91,692 (300)

Neuromuscular junction dysfunction in Lafora disease [PDF]

Disease Models & Mechanisms
Monica Shukla, Deepti Chugh, Subramaniam Ganesh   +2 more
doaj   +2 more sources

Chronic aryl hydrocarbon receptor activity phenocopies smoking‐induced skeletal muscle impairment

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Chronic obstructive pulmonary disease (COPD) patients exhibit skeletal muscle atrophy, denervation, and reduced mitochondrial oxidative capacity.
Trace Thome, Kayla Miguez, Alexander J. Willms, Sarah K. Burke, Vijayendran Chandran, Angela R. deSouza, Liam F. Fitzgerald, Carolyn Baglole, Maria‐Eleni Anagnostou, Jean Bourbeau, R. Thomas Jagoe, Jose A. Morais, Yana Goddard, Tanja Taivassalo, Terence E. Ryan, Russell T. Hepple   +15 more
doaj   +1 more source

Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis

Neural Regeneration Research, 2021
Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the ...
Francisco J Barrantes
doaj   +1 more source

Mathematical modeling of the Drosophila neuromuscular junction [PDF]

, 2009
Poster presentation: An important challenge in neuroscience is understanding how networks of neurons go about processing information. Synapses are thought to play an essential role in cellular information processing however quantitative and mathematical ...
Bucher, Daniel, Knodel, Markus Michael, Queisser, Sean Gillian, Schuster, Christoph M., Wittum, Gabriel   +4 more
core   +1 more source

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa, Megighian, Aram, Montecucco, Cesare, Pirazzini, Marco, Rigoni, Michela, Scorzeto, M., Zanetti, Giulia   +6 more
core   +2 more sources

Denervation-Related Neuromuscular Junction Changes: From Degeneration to Regeneration

Frontiers in Molecular Neuroscience, 2022
Neuromuscular junctions (NMJs) are the key interface between terminal nerves and targeted muscle, which undergo degeneration during denervation periods. Denervation-related NMJs changes limits the recovery level of nerve repair strategies.
Xinying Huang, Xinying Huang, Xinying Huang, Xinying Huang, Junjian Jiang, Junjian Jiang, Junjian Jiang, Jianguang Xu, Jianguang Xu, Jianguang Xu   +9 more
doaj   +1 more source

Autoimmune Channelopathies at Neuromuscular Junction

Frontiers in Neurology, 2019
The neuromuscular junction, also called myoneural junction, is a site of chemical communication between a nerve fiber and a muscle cell. There are many types of channels at neuromuscular junction that play indispensable roles in neuromuscular signal ...
Kun Huang, Kun Huang, Yue-Bei Luo, Huan Yang   +3 more
doaj   +1 more source

Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy [PDF]

, 2016
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity.
Brophy, Peter J., Gillingwater, Thomas H., Groen, Ewout J.N., Hunter, Gillian, Jones, Ross A., Lane, Fiona M., Powis, Rachael A., Sherman, Diane L., Shorrock, Hannah K., Zheng, Yinan   +9 more
core   +3 more sources

Facilitation of transmitter release at squid synapses [PDF]

, 1978
Facilitation is shown to decay as a compound exponential with two time constants (T1, T2) at both giant and non-giant synapses in squid steilate ganglia bathed in solutions having low extracellular calcium concentrations ([Ca++]o).
Bittner, George D., Charlton, Milton P.
core   +1 more source

NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy

Skeletal Muscle, 2019
Background Secondary dystroglycanopathies are muscular dystrophies that result from mutations in genes that participate in Dystroglycan glycosylation.
Erin C. Bailey, Sarah S. Alrowaished, Elisabeth A. Kilroy, Emma S. Crooks, Daisy M. Drinkert, Chaya M. Karunasiri, Joseph J. Belanger, Andre Khalil, Joshua B. Kelley, Clarissa A. Henry   +9 more
doaj   +1 more source