Results 21 to 30 of about 442,682 (288)

Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis

Neural Regeneration Research, 2021
Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the ...
Francisco J Barrantes
doaj   +1 more source

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane [PDF]

, 2012
Agrin is the major factor mediating the neuronal regulation of postsynaptic structures at the vertebrate neuromuscular junction, but the details of how it orchestrates this unique three-dimensional structure remain unknown.
Jeffrey van Haren, Galjart N, Sladecek, S. (Stefan), Haren, Jeffrey van, van Haren, J., Hans Rudolf Brenner, Schmidt, Nadine, Treves, Susan, van Haren J, Pielage, J. (Jan), Jan Pielage, Sreya Basu, Brenner H.R., TREVES, Susan Nella, Gatti, Sabrina, Pielage J, Schmidt N, van Haren, Jeffrey; id_orcid, Pielage, Jan, Galjart, Niels; id_orcid, Basu S, Gatti, A. (Arianna), Brenner, H.R. (Hans Rudolf), Niels Galjart, Sladecek, S., Gatti S, Basu, Sreya, Susan Treves, Schmidt, N. (Nico), Sabrina Gatti, Haren, J.A.J. (Jeffrey) van, Treves, S., Galjart, N., Stefan Sladecek, Pielage, J., Brenner, H. R., Basu, S. (Saonli), Galjart, N.J. (Niels), Gatti, S., Nadine Schmidt, Sladecek S, Galjart, Niels, Schmidt, N., Basu, S., Sladecek, Stefan, Brenner, Hans Rudolf   +45 more
core   +1 more source

Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction [PDF]

, 2004
The subunit composition of postsynaptic neurotransmitter receptors is a key determinant of synaptic physiology. Two glutamate receptor subunits, Drosophila glutamate receptor IIA (DGluRIIA) and DGluRIIB, are expressed at the Drosophila neuromuscular ...
Portman, Scott L., DiAntonio, Aaron, Allen, Marcus J., Marrus, Scott B., Moffat, Kevin G., Allen, Marcus James   +5 more
core   +1 more source

Denervation-Related Neuromuscular Junction Changes: From Degeneration to Regeneration

Frontiers in Molecular Neuroscience, 2022
Neuromuscular junctions (NMJs) are the key interface between terminal nerves and targeted muscle, which undergo degeneration during denervation periods. Denervation-related NMJs changes limits the recovery level of nerve repair strategies.
Xinying Huang, Xinying Huang, Xinying Huang, Xinying Huang, Junjian Jiang, Junjian Jiang, Junjian Jiang, Jianguang Xu, Jianguang Xu, Jianguang Xu   +9 more
doaj   +1 more source

NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy

Skeletal Muscle, 2019
Background Secondary dystroglycanopathies are muscular dystrophies that result from mutations in genes that participate in Dystroglycan glycosylation.
Erin C. Bailey, Sarah S. Alrowaished, Elisabeth A. Kilroy, Emma S. Crooks, Daisy M. Drinkert, Chaya M. Karunasiri, Joseph J. Belanger, Andre Khalil, Joshua B. Kelley, Clarissa A. Henry   +9 more
doaj   +1 more source

Juvenile Neuromuscular Systems Show Amplified Disturbance to Muscle Unloading

Frontiers in Physiology, 2021
Muscle unloading results in severe disturbance in neuromuscular function. During juvenile stages of natural development, the neuromuscular system experiences a high degree of plasticity in function and structure.
Michael R. Deschenes, Michael R. Deschenes, Leah G. Patek, Audrey M. Trebelhorn, Madeline C. High, Rachel E. Flannery   +5 more
doaj   +1 more source

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K., Plomp, J.J., Willison, H.J., Willison, HJ, Verschuuren, JJ, Todorov, B, Furukawa, K, Jacobs, B.C., Zitman, FMP, Todorov, B., Zitman, F.M.P., Verschuuren, J.J., Plomp, JJ   +12 more
core   +1 more source

DOXAPRAM AND THE NEUROMUSCULAR JUNCTION †

British Journal of Anaesthesia, 1989
We have studied the action of doxapram on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation. Doxapram augmented neuromuscular transmission in a dose-related manner when a threshold concentration of 5 x 10(-5) mol litre-1 had been exceeded.
B J, Pollard, N P, Randall, B J, Pleuvry
openaire   +2 more sources

Agrin promotes acetylcholine receptor clustering at the mammalian neuro-muscular junction by PI3K/GSK3ß²-mediated regulation of +TIPs and microtubule capture [PDF]

, 2013
Neurotransmission an der neuromuskulären Endplatte von Säugetieren erfolgt durch Ausschüttung von Acetylcholin (ACh) aus motorischen Nerven in den synaptischen Spalt und verursacht letztendlich Muskelkontraktion im angesteuerten Muskel.
Sladecek, Stefan
core   +1 more source

Farmacocinética y farmacodinamia del bromuro de rocuronio: Influencia de la terapia crónica con fenitoína. [PDF]

, 2010
[spa] ANTECEDENTES: La administración crónica de fármacos antiepilépticos disminuye la intensidad del efecto de los fármacos bloqueantes neuromusculares (BNM), aunque existe cierta discrepancia a la hora de explicar si esta interacción se produce a nivel
Fernández Candil, Juan Luís
core   +6 more sources