Results 41 to 50 of about 91,692 (300)

Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor

Frontiers in Physiology, 2021
Recent studies have demonstrated that neuromuscular junctions are co-innervated by sympathetic neurons. This co-innervation has been shown to be crucial for neuromuscular junction morphology and functional maintenance. To improve our understanding of how
Tatjana Straka, Tatjana Straka, Tatjana Straka, Charlotte Schröder, Andreas Roos, Andreas Roos, Laxmikanth Kollipara, Albert Sickmann, Albert Sickmann, Albert Sickmann, Marion Patrick Ivey Williams, Mathias Hafner, Muzamil Majid Khan, Muzamil Majid Khan, Muzamil Majid Khan, Rüdiger Rudolf, Rüdiger Rudolf, Rüdiger Rudolf   +17 more
doaj   +1 more source

ATP Released by Injured Neurons Activates Schwann Cells [PDF]

, 2016
Injured nerve terminals of neuromuscular junctions (NMJs) can regenerate. This remarkable and complex response is governed by molecular signals that are exchanged among the cellular components of this synapse: motor axon nerve terminal (MAT ...
Cesare eMontecucco, Cesare eMontecucco, Elisa eDuregotti, Elisanna eBergamin, Kees eJalink, Michela eRigoni, Michele eScorzeto, Samuele eNegro, Umberto eRodella   +8 more
core   +2 more sources

Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

Neurobiology of Disease, 2019
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure.
Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton   +20 more
doaj   +1 more source

Role of Neuromuscular Junction Monitoring in Management of a Postpartum Eclamptic Patient with Iatrogenic Hypermagnesemia [PDF]

The Indian Anaesthetists' Forum, 2010
Accidental hypermagnesemia is a common and often missed complication during treatment in a postpartum eclamptic patient. As symptomatic hypermagnesemia leads to neuromuscular junction blockade, neuromuscular junction monitoring serves the purpose of ...
Harshel G Parikh, Chitra B Upasani
doaj  

Systematic review of mitochondrial dysfunction and oxidative stress in aging: A focus on neuromuscular junctions

Neural Regeneration Research
Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.
Senlin Chai, Ning Zhang, Can Cui, Zhengyuan Bao, Qianjin Wang, Wujian Lin, Ronald Man Yeung Wong, Sheung Wai Law, Rebecca Schönmehl, Christoph Brochhausen, Wing Hoi Cheung   +10 more
doaj   +1 more source

Agrin isoforms and their role in synaptogenesis [PDF]

, 1992
Agrin is thought to mediate the motor neuron-induced aggregation of synaptic proteins on the surface of muscle fibers at neuromuscular junctions. Recent experiments provide direct evidence in support of this hypothesis, reveal the nature of agrin ...
Escher, Gérard, Honig, Lawrence S., Horton, Sharon E., Kröger, Stephan, McMahan, U. J., Ruegg, Markus A., Werle, Michael J.   +6 more
core   +1 more source

Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units

Cell Reports, 2019
Summary: Age-related loss of skeletal muscle innervation by motor neurons leads to impaired neuromuscular function and is a well-established clinical phenomenon. However, the underlying pathogenesis remains unclear. Studying mice, we find that the number
Elisa Giorgetti, Moh Panesar, Yunyu Zhang, Stefanie Joller, Marie Ronco, Michael Obrecht, Christian Lambert, Nathalie Accart, Nicolau Beckmann, Arno Doelemeyer, Ludovic Perrot, Isabelle Fruh, Matthias Mueller, Eliane Pierrel, Serge Summermatter, Michael Bidinosti, Derya R. Shimshek, Sophie Brachat, Mark Nash   +18 more
doaj   +1 more source

SnapShot: Neuromuscular Junction

Cell, 2011
Agrin MuSK Dok-7Rapsyn AChR AChE ChAT Nav1.4Auto-antibodiesto AChRsAuto-antibodiesto MuSKHypomorphic mutations in thesegenes impair postsynaptic differentiation. The number of AChRs at synapses is reduced, which compromises the reliability of synaptic transmission and leads to muscle weakness and fatigue.
openaire   +2 more sources

O-GlcNAcase contributes to cognitive function in Drosophila [PDF]

, 2020
Contains fulltext : 219183.pdf (publisher's version ) (Open ...
Catinozzi, Marica, Eidhof, Ilse, Fenckova, Michaela, Ferenbach, Andrew, Muha, Villo, Schenck, Annette, Storkebaum, Erik, van Aalten, Daan   +7 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source