Results 61 to 70 of about 59,298 (301)
Therapeutics Targeting Skeletal Muscle in Amyotrophic Lateral Sclerosis
BiomoleculesAmyotrophic lateral sclerosis (ALS) is a complex neuromuscular disease characterized by progressive motor neuron degeneration, neuromuscular junction dismantling, and muscle wasting.
Jinghui Gao +4 more
doaj +1 more source
Effect of ulinastatin on the rocuronium-induced neuromuscular blockade [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundUlinastatin is a glycoprotein derived from human urine and a serine protease inhibitor found in human urine and blood. Ulinastatin increases both liver blood flow and urine output.
Min Soo Kim +5 more
doaj +1 more source
Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation
Advanced Science, EarlyView.A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou +12 more
wiley +1 more source
Electrophysiological study in neuromuscular junction disorders
Annals of Indian Academy of Neurology, 2013 This review is on ultrastructure and subcellular physiology at normal and abnormal neuromuscular junctions. The clinical and electrophysiological findings in myasthenia gravis, Lambert-Eaton myasthenic syndrome (LEMS), congenital myasthenic syndromes ...
Ajith Cherian +2 more
doaj +1 more source
Newcomb–Benford’s Law in Neuromuscular Transmission: Validation in Hyperkalemic Conditions
Stats, 2023 Recently, we demonstrated the validity of the anomalous numbers law, known as Newcomb–Benford’s law, in mammalian neuromuscular transmission, considering different extracellular calcium.
Adriano Silva +2 more
doaj +1 more source
Advanced Science, EarlyView.Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu +10 more
wiley +1 more source
A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction [PDF]
, 2009 Adult skeletal muscle accepts ectopic innervation by foreign motor axons only after section of its own nerve, suggesting that the formation of new neuromuscular junctions is promoted by muscle denervation.
Lain, Enzo +7 more
core +1 more source
Motoneuron Wnts regulate neuromuscular junction development
eLife, 2018 The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Unlike extensively investigated postsynaptic differentiation, less is known about mechanisms of presynaptic assembly.
Chengyong Shen +14 more
doaj +1 more source
Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents [PDF]
Korean Journal of Anesthesiology, 2017 Neuromuscular blockade plays an important role in the safe management of patient airways, surgical field improvement, and respiratory care. Rapid-sequence induction of anesthesia is indispensable to emergency surgery and obstetric anesthesia, and its ...
Yong Byum Kim +2 more
doaj +1 more source
SnapShot: Neuromuscular Junction
Cell, 2011 Agrin MuSK Dok-7Rapsyn AChR AChE ChAT Nav1.4Auto-antibodiesto AChRsAuto-antibodiesto MuSKHypomorphic mutations in thesegenes impair postsynaptic differentiation. The number of AChRs at synapses is reduced, which compromises the reliability of synaptic transmission and leads to muscle weakness and fatigue.
openaire +2 more sources