Results 41 to 50 of about 10,137 (277)
A structural systematic study of four isomers of difluoro-N-(3-pyridyl)benzamide [PDF]
, 2009 The four isomers 2,4-, (I), 2,5-, (II), 3,4-, (III), and 3,5-difluoro-N-(3-pyridyl)benzamide, (IV), all with formula C12H8F2N2O, display molecular similarity, with interplanar angles between the C6/C5N rings ranging from 2.94 (11)° in (IV) to 4.48 (18 ...
Anderson, Frankie P. +3 more
core +1 more source
A New Class of Small Molecule Inhibitor of BMP Signaling [PDF]
, 2013 Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor kinase ALK2 (ACVR1) are needed ...
Bullock, AN +11 more
core +13 more sources
Palladium-catalysed amination of electron-deficient or relatively-rich benzo[b]thienylbromides: preliminary studies of antimicrobial activity and SARs [PDF]
, 2004 Several diarylamines in the benzo[b]thiophene series were prepared by palladium catalyzed amination of ethyl 3-bromobenzo[b]thien-2-yl carboxylate with anilines and 5-aminoindole, in good to high yields using Pd(OAc)2, BINAP, Cs2CO3 in toluene.
Barbosa, Sandra +6 more
core +2 more sources
Pyridinium N-2 '-pyridylaminide: radical cyclization in the synthesis of annulated 2-aminopyridines [PDF]
, 2006 The synthesis of annulated 2-aminopyridines by intramolecular radical pyridylation of the appropriate substrates, obtained from pyridinium N-2'-pyridylaminide, can be performed using TTMSS and AIBN.Financial support by the CICYT (Project CTQ2005-08902 ...
Burgos García, Carolina +3 more
core +3 more sources
Molecules, 2007 An improved synthetic method affording 4-chlorocoumarin-3-sulfonyl chloride (4) in very good yield (ca. 85 %) is reported. This compound was reacted with various bidentate nucleophiles such as 2-aminopyridines and 2-aminothiazoles in order to obtain ...
Emil Popovski +4 more
doaj +1 more source
Molbank, 2021 Synthesis of a series of the substituted [(pyridinyl and pyrimidin-2-ylimino)-ethyl]-4-hydroxy-chromen-2-ones and their tetrazole derivates is presented in this study. By catalytic condensation of 4-hydroxy-3-acetylcoumarine 2 and 2-aminopyridines 3(a-d),
Ramiz Hoti +5 more
doaj +1 more source
Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains
Beilstein Journal of Organic Chemistry, 2017 Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines.
Layal Hariss +5 more
doaj +1 more source
Flow Hydrodediazoniation of Aromatic Heterocycles
Molecules, 2019 Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment
Liesa Röder +2 more
doaj +1 more source
A structural systematic study of three isomers of difluoro-N-(4-pyridyl)benzamide [PDF]
, 2008 The isomers 2,3-, (I), 2,4-, (II), and 2,5-difluoro-N-(4-pyridyl)benzamide, (III), all with formula C₁₂H₈F₂N₂O, all exhibit intramolecular C-H...O=C and N-H...F contacts [both with S(6) motifs].
Anderson, Frankie P. +3 more
core +1 more source
The Reaction of 2-Aminopyridines with Ethyl Diazoacetate
CHIMIA, 1974 It has been found that ethyl diazoacetate reacted with 2- amino-pyridines to give the corresponding 2-carbethoxy- methylaminopyridines (1). In m-xylene as solvent, thermal decomposition of the diazo ester proceeded with preferential attack on m-xylene ...
B. Doma +3 more
doaj +1 more source