Results 41 to 50 of about 7,735 (236)
Molecules, 2022 A new and suitable multicomponent one-pot reaction was developed for the synthesis of 2-amino-3-cyanopyridine derivatives. Background: This synthesis was demonstrated by the efficient and easy access to a variety of substituted 2-aminopyridines using ...
Zahira Kibou +6 more
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METHODS OF NITROPYRIDINE SYNTHESIS
Siberian Journal of Life Sciences and Agriculture, 2021 Background. Pyridine derivatives are widely used in pharmaceuticals, agrochemistry, as well as in the production of new materials. The pyridine and piperidine rings are the main structural fragments of numerous natural alkaloids with a wide spectrum of ...
Evgeniya V. Ivanova +4 more
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Tropical Medicine and Infectious Disease, 2023 Chagas disease is derived from the infection by the protozoan Trypanosoma cruzi. In many countries, benznidazole is the only drug approved for clinical use despite several side effects and the emergence of resistant parasite strains. In this context, our
Rafaela Silva-Oliveira +5 more
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6-Benzyl-3,4-dimethoxy-10-methylpyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-one
Acta Crystallographica Section E, 2009 Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones such as the title compound, C24H21N3O3, can be obtained in a few minutes in a microwave-assisted three-component reaction from 2-aminopyridines, isocyanides and 2 ...
Kathrin Meindl +3 more
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Biota. Human. Technology, 2022 Purpose. Synthesis and study of antioxidant properties of [1,2,4]triazolo[1,5-a]pyridine derivatives and their potential toxicity using preclinical diagnostic methods. Methodology.
Олександр Смольський +3 more
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Aminopyridines for the treatment of neurologic disorders [PDF]
Neurology Clinical Practice, 2017 To identify the different indications for the treatment of neurologic disorders with the potassium channel blockers 4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP).4-AP is an effective symptomatic treatment for downbeat nystagmus (DBN), episodic ataxia type 2 (EA2) (5-10 mg TID), and impaired gait in multiple sclerosis (MS) (10 mg BID).
Michael, Strupp +5 more
openaire +2 more sources
GAA‐FGF14 Ataxia Is a Frequently Overlooked Cause of Sporadic Adult‐Onset Ataxia
Clinical Genetics, EarlyView.GAA‐FGF14 ataxia is a frequent cause of both familial and sporadic cerebellar ataxia. If symptoms are consistent, targeted testing of the FGF14 locus should be considered as a first‐line approach, as the diagnostic yield is up to 50%. ABSTRACT GAA‐FGF14 ataxia (spinocerebellar ataxia 27B, SCA27B), identified in 2023, is a major cause of adult‐onset ...
Eva‐Maria Kraus +7 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov +8 more
wiley +1 more source
The physiological basis of therapies for cerebellar ataxias
Therapeutic Advances in Neurological Disorders, 2016 Cerebellar ataxias represent a group of heterogeneous disorders impacting on activities of daily living and quality of life. Various therapies have been proposed to improve symptoms in cerebellar ataxias. This review examines the physiological background
Hiroshi Mitoma, Mario Manto
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The Journal of Physiology, EarlyView.Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg +3 more
wiley +1 more source