Results 61 to 70 of about 7,735 (236)

Microelectrode array scaled for human hippocampal slices

Epilepsia Open, Volume 11, Issue 3, Page 777-786, June 2026.
Abstract Objective Temporal lobe epilepsy (TLE) is characterized by recurrent seizures originating usually from the hippocampus, and approximately one‐third of TLE patients remain refractory to pharmacological interventions. Surgical resection offers a potential cure for refractory TLE cases, with approximately 70% achieving seizure freedom. Still, the
Anssi Pelkonen, Vera Lezhneva, Tomi Ryynänen, Joose Kreutzer, Valeriia Sitnikova, Mireia Gómez‐Budia, Adriana Della Pietra, Antonios Dougalis, Jenni Kyyriäinen, Mastaneh Torkamani‐Azar, Henri Eronen, Tuomas Rauramaa, Arto Immonen, Ville Leinonen, Alejandra Sierra, Reetta Kälviäinen, Tarja Malm   +16 more
wiley   +1 more source

A NEW ROUTE FOR THE SYNTHESIS OF 2 AMINOPYRIDINES

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
The 2-aminopyridines constitute a very large class of nitrogen heterocycles, which have a great biological activity, such as the antibacterial, anti-inflammatory and analgesics activity, as well as the 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8 ...
Zahira Kibou, Nawel Cheikh, Noureddine Choukchou-Braham, Bachir Mostefa-Kara, Mohammed Benabdellah, Didier Villemin   +5 more
doaj  

Structural diversity of different aminomethylpyridinium hexafluoridosilicates

Acta Chimica Slovenica
A series of new aminomethylpyridinium hexafluoridosilicate salts with the formula (RH)2[SiF6] (where R = 2-amino-3-methylpyridine (1), 2-amino-4-methylpyridine (2), 2-amino-5-methylpyridine (3) and 2-amino-6-methylpyridine (4)) were prepared by the ...
Andrej Pevec
doaj   +1 more source

Structure and intermolecular interactions of the rare amide–pyridine synthon: a cocrystal of nicotinamide and 2‐chloro‐3‐hydroxypyridine

Acta Crystallographica Section C, Volume 82, Issue 6, Page 267-276, June 2026.
Considering its low occurrence in the Cambridge Structural Database, is the amide–pyridyl synthon easy to form, and what structural factors affects its interaction energy and its subsequent formation?Nicotinamide (Nico) and derivatives of pyridine are important materials in both the pharmaceutical and agrochemical industries.
Oluwatoyin Akerele, Andreas Lemmerer
wiley   +1 more source

NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells

The Journal of Physiology, Volume 604, Issue 12, Page 4926-4944, 15 June 2026.
Abstract figure legend Vibrodissociated Pukinje neurons retain active synaptic connections, including those from adhering fragments of the climbing fibre. These fragments generate excitatory synaptic events and the frequency of these events is increased by exposure to either NMDA [with d‐serine (d‐ser) as a co‐agonist] or glycine at a high (100 µM ...
David C. H. Benton, Alan D. Robertson, Matthew Caldwell, Yuriy Pankratov, Lema Imam, Trevor G. Smart, Gareth Morris, Guy W. J. Moss   +7 more
wiley   +1 more source

Orchestration of PKC‐Mediated Inhibition and Calcium Release‐Mediated Activation of BK Currents in Rat Vascular Smooth Muscle Cells by Melatonin Confers a BK‐Channel‐Dependent Restraint on Melatonin‐Induced Vasocontraction

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Melatonin‐evoked BK current stimulation limits melatonin‐induced vasocontraction. Counter‐regulatory role for BK current depends on PLC‐dependent signaling cross‐talk. Stimulation of BK current involves melatonin‐induced IP3‐mediated calcium release leading to activation of BK channels. Stimulation of BK current involves melatonin‐induced activation of
Anastasia Pyanova, Vjatscheslav U. Kalentchuk, Vladimir N. Serebryakov, Rudolf Schubert   +3 more
wiley   +1 more source

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

Characteristics of weak base-induced vacuoles formed around individual acidic organelles

Folia Histochemica et Cytobiologica, 2011
We have previously found that the weak base 4-aminopyridine induces Brownian motion of acidic organelles around which vacuoles are formed, causing organelle traffic disorder in neurons.
Tadashi Kawakami, Hiromi Hiruma
doaj   +1 more source

Synthesis of 1,2,4-Triazolo[4,3-a]pyridines by I₂-Catalyzed Oxidative Coupling of 2-Aminopyridines with N-Tosylhydrazones [PDF]

, 2022
Yongxin Chen, Guo Xin, Liu Yafeng, Xueying Yang, Chen Baohua   +4 more
openalex   +1 more source

Correction to: Podophyllum derivatives containing fluorine atom in the 3-position of 2-aminopyridine improved the antitumor activity by inducing P53-dependent apoptosis [PDF]

, 2018
Huai Wang
openalex   +1 more source