Results 51 to 60 of about 10,137 (277)
Molecules, 2022 A new and suitable multicomponent one-pot reaction was developed for the synthesis of 2-amino-3-cyanopyridine derivatives. Background: This synthesis was demonstrated by the efficient and easy access to a variety of substituted 2-aminopyridines using ...
Zahira Kibou +6 more
doaj +1 more source
The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions [PDF]
, 2018 Accepted for publication in a future issue of Future Medicinal Chemistry.The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative ...
Blomberg N +6 more
core +2 more sources
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
METHODS OF NITROPYRIDINE SYNTHESIS
Siberian Journal of Life Sciences and Agriculture, 2021 Background. Pyridine derivatives are widely used in pharmaceuticals, agrochemistry, as well as in the production of new materials. The pyridine and piperidine rings are the main structural fragments of numerous natural alkaloids with a wide spectrum of ...
Evgeniya V. Ivanova +4 more
doaj +1 more source
Tackling resistance: Emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved] [PDF]
, 2018 Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites.
Matthews, Emily S, Odom John, Audrey R
core +2 more sources
Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues
Advanced Science, EarlyView.Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak +6 more
wiley +1 more source
Tropical Medicine and Infectious Disease, 2023 Chagas disease is derived from the infection by the protozoan Trypanosoma cruzi. In many countries, benznidazole is the only drug approved for clinical use despite several side effects and the emergence of resistant parasite strains. In this context, our
Rafaela Silva-Oliveira +5 more
doaj +1 more source
Structure property relationships in halogenated aromatic amides and imides [PDF]
, 2017 The effect of halogens (X) and pyridine N atom substitution patterns on molecular structure and conformation is analyzed and discussed herein. Several series of 3 x 3 isomer grids (Scheme 1; Figs 1-3) of halo-N-(pyridyl)benzamides (Xxx) (C12H9N2OX, x ...
Aubert, E. +5 more
core +2 more sources
Advanced Science, EarlyView.The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu +10 more
wiley +1 more source
European Journal of Organic Chemistry, EarlyView.1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer +6 more
wiley +1 more source