4-Aminopyridine Improves Lower Urinary Tract Symptoms in a Patient With Benign Prostatic Hyperplasia and Downbeat Nystagmus Syndrome [PDF]
International Neurourology Journal, 2014 Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders.
Michael Strupp +3 more
doaj +1 more source
Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders [PDF]
, 2019 Cerebellar ataxia is a frequent and often disabling syndrome severely impairing motor functioning and quality of life. Patients suffer from reduced mobility, and restricted autonomy, experiencing an even lower quality of life than, e.g., stroke survivors.
Strupp, M., Kalla, Roger
core +1 more source
Merging C–H Bond Functionalization with Amide Alcoholysis: En Route to 2‑Aminopyridines [PDF]
, 2016 A new route for the synthesis of 2-aminopyridines has been developed that merges C–H functionalization with amide alcoholysis. The key component of this method is the ability of a quinazolinone to template the chemo- and regioselective construction of a ...
Sandeep R. Vemula (2637823) +2 more
core +1 more source
Molecules, 2007 An improved synthetic method affording 4-chlorocoumarin-3-sulfonyl chloride (4) in very good yield (ca. 85 %) is reported. This compound was reacted with various bidentate nucleophiles such as 2-aminopyridines and 2-aminothiazoles in order to obtain ...
Emil Popovski +4 more
doaj +1 more source
Molbank, 2021 Synthesis of a series of the substituted [(pyridinyl and pyrimidin-2-ylimino)-ethyl]-4-hydroxy-chromen-2-ones and their tetrazole derivates is presented in this study. By catalytic condensation of 4-hydroxy-3-acetylcoumarine 2 and 2-aminopyridines 3(a-d),
Ramiz Hoti +5 more
doaj +1 more source
Theoretical Models and QSRR in Retention Modeling of Eight Aminopyridines [PDF]
, 2016 In this article, retention modeling of eight aminopyridines (synthesized and characterized at the Faculty of Pharmacy) in reversed-phase high performance liquid chromatography (RP-HPLC) was performed.
Jančić-Stojanović, Biljana +6 more
core +1 more source
Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains
Beilstein Journal of Organic Chemistry, 2017 Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines.
Layal Hariss +5 more
doaj +1 more source
Flow Hydrodediazoniation of Aromatic Heterocycles
Molecules, 2019 Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment
Liesa Röder +2 more
doaj +1 more source
Synthesis of Aminopyridines and Aminopyridones by Cobalt-Catalyzed [2+2+2] Cycloadditions Involving Yne-Ynamides: Scope, Limitations, and Mechanistic Insights [PDF]
, 2012 International audienceAn in-depth study of the cobalt-catalyzed [2+2+2] cycloaddition between yne-ynamides and nitriles to afford aminopyridines has been carried out.
Sevrin, Mireille +7 more
core +1 more source
The Reaction of 2-Aminopyridines with Ethyl Diazoacetate
CHIMIA, 1974 It has been found that ethyl diazoacetate reacted with 2- amino-pyridines to give the corresponding 2-carbethoxy- methylaminopyridines (1). In m-xylene as solvent, thermal decomposition of the diazo ester proceeded with preferential attack on m-xylene ...
B. Doma +3 more
doaj +1 more source