Microwave-Assisted One-Pot Telescoped Synthesis of 2-Amino-1,3-thiazoles, Selenazoles, Imidazo[1,2-<i>a</i>]pyridines, and Other Heterocycles from Alcohols. [PDF]
J Org ChemPrimary and secondary alcohols have been con-verted into 2-amino-1,3-thiazoles under microwave irradiation,employing trichloroisocyanuric acid (TCCA) as a dual oxidant andchlorine source, TEMPO as a co-oxidant, and thiourea. Secondaryalcohols underwent a
Macías-Benítez P +3 more
europepmc +3 more sources
Diversity-Oriented Synthesis of [2.2]Paracyclophane-derived Fused Imidazo[1,2-a]heterocycles by Groebke-Blackburn-Bienayme Reaction : Accessing Cyclophanyl Imidazole Ligands Library [PDF]
, 2021 This report describes the synthesis of a [2.2]paracyclophane-derived annulated 3-amino-imidazole ligand library through a Groebke-Blackburn-Bienayme three-component reaction (GBB-3CR) approach employing formyl-cyclophanes in combination with diverse ...
Brase, Stefan +6 more
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A Dual Read-Out Assay to Evaluate the Potency of Compounds Active against Mycobacterium tuberculosis [PDF]
, 2012 PMCID: PMC3617142This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Alling, T +7 more
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Phosphorylated imidazo[1,2‐a]pyridines
Heteroatom Chemistry, 1995 AbstractThe reaction of phosphorus(III) halides with imidazo[1,2‐a]pyridines in the presence of bases leads to the formation of 3‐phosphorylated imidazo[1,2‐a]pyridines. The reaction proceeds in high yield and requires no catalysts.In the compounds obtained, in contrast to phosphorylated indolizines, the phosphorus–heterocycle bond is stable and not ...
Andrew A. Tolmachev +5 more
openaire +1 more source
Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions [PDF]
, 2016 A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale).
A. John Blacker +54 more
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Fluorination methods in drug discovery [PDF]
, 2016 Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that the fluorine atom can impart ...
Bonesi, Sergio Mauricio +2 more
core +1 more source
Novel Strategies for Fluorine‐18 Radiochemistry [PDF]
, 2012 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90272/1/1106_ftp ...
Agard +23 more
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An easy preparation of pyridinium N-heteroarylaminides [PDF]
, 2004 A synthesis of substituted pyridinium N-heteroarylaminides, e.g., I, is reported. Heteroaryl chlorides underwent nucleophilic substitution with N-aminopyridinium iodide to give the corresponding substituted pyridinium N-heteroarylaminides in good yields.
Burgos García, Carolina +3 more
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Mycobacterial Interspersed Repetitive Unit Can Predict Drug Resistance of Mycobacterium tuberculosis in China [PDF]
, 2016 BackgroundRecently, Mycobacterial Interspersed Repetitive Unit (MIRU) was supposed to be associated with drug resistance in M.tuberculosis (MTB). However, whether the MIRU was related to drug resistance actually was still unknown.
Chao Jiang +7 more
core +2 more sources
Synthetic and theoretical studies of novel ring closure and ring opening reactions [PDF]
, 2006 Ring closure and ring opening reactions are in many cases useful synthetic procedures in organic chemistry. They allow the preparation of complex molecules with high stereoselectivity and good yields. Mechanistic and theoretical studies have been carried
González Rosende, Mª Eugenia +1 more
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