Results 1 to 10 of about 81,920,088 (158)

Imidazo(1,2-a)pyridines. II. Ozonolysis of Imidazo(1,2-a)pyridines and Synthesis of Cardiotonic Agents.

Chemical and Pharmaceutical Bulletin, 1992
The metabolite of loprinone (E-1020) in dogs, 5-(2-aminopyridin-5-yl)-1, 2-dihydro-6-methyl-2-oxo-3-pyridine-carbonitrile (9), was prepared via ozonolysis of imidazo[1, 2-α]pyridinylpyridines and evaluated for positive inotropic activity. Its potency was less than that of loprinone and milrinone.
YAMANAKA, Motosuke, SUDA, Shinji, YONEDA, Naoki, OHHRA, Hideto   +3 more
openaire   +3 more sources

Phosphorylated imidazo[1,2‐a]pyridines

Heteroatom Chemistry, 1995
AbstractThe reaction of phosphorus(III) halides with imidazo[1,2‐a]pyridines in the presence of bases leads to the formation of 3‐phosphorylated imidazo[1,2‐a]pyridines. The reaction proceeds in high yield and requires no catalysts.In the compounds obtained, in contrast to phosphorylated indolizines, the phosphorus–heterocycle bond is stable and not ...
Andrew A. Tolmachev, Alexander A. Yurchenko, Ernest S. Kozlov, Anatoliy S. Merkulov, Marina G. Semenova, Aleksander M. Pinchuk   +5 more
openaire   +1 more source

Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt [PDF]

Bioorganic & Medicinal Chemistry Letters, 2014
We report the design, synthesis, and biological evaluation of imidazopyridine-based peptidomimetics based on the substrate consensus sequence of Akt, an AGC family serine/threonine kinase hyperactivated in over 50% of human tumors. Our ligand-based approach led to the identification of novel substrate mimetic inhibitors of Akt1 featuring an unnatural ...
Young B, Kim, Chang Won, Kang, Sujeewa, Ranatunga, Hua, Yang, Said M, Sebti, Juan R, Del Valle   +5 more
openaire   +2 more sources

Imidazo(1,2-a)pyridines. III. Synthesis and Bradycardic Activity of New 5-Imidazo(1,2-a)pyridin-6-ylpyridine Derivatives.

Chemical and Pharmaceutical Bulletin, 1992
Structural modification of the cardiotonic agent, loprinone (E-1020, 1), suggested by data that it has a less positive chronotropic effect than milrinone (15), led us to find novel bradycardic agents that were structurally different from homoveratryl amine derivatives. Alkyl-oxy, -thio, and -amino derivatives at the 2-position of the pyridine ring of 1
YAMANAKA, Motosuke, SUDA, Shinji, KABASAWA, Yasuhiro, KAWAMURA, Takanori, OGAWA, Toshiaki, SAWADA, Kouhei, OHHARA, Hideto   +6 more
openaire   +3 more sources

Diethylaminosulfur Trifluoride: A Novel, Low-Cost, Stable Double Thiolation Reagent for Imidazo[1,2-α]pyridines. [PDF]

ACS Omega, 2021
Jiang H, Shen H, Zhu S, Wang B, Yang Y, Nong Z, Yi M, Tang S, Gui QW.   +8 more
europepmc   +1 more source

Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C-H Functionalization Mediated by tert-Butyl Hydroperoxide. [PDF]

ACS Omega, 2021
Yang H, Huang N, Wang N, Shen H, Teng F, Liu X, Jiang H, Tan MC, Gui QW.   +8 more
europepmc   +1 more source

In Silico Screening of Novel α1-GABA_A Receptor PAMs towards Schizophrenia Based on Combined Modeling Studies of Imidazo [1,2-a]-Pyridines. [PDF]

Int J Mol Sci, 2021
Zheng X, Wang C, Zhai N, Luo X, Liu G, Ju X.   +5 more
europepmc   +1 more source

Recent Progress in Metal-Free Direct Synthesis of Imidazo[1,2-a]pyridines. [PDF]

ACS Omega, 2021
Kurteva V.
europepmc   +1 more source

Exploratory toxicology studies of 2,3-substituted imidazo[1,2-a]pyridines with antiparasitic and anti-inflammatory properties. [PDF]

Toxicol Res (Camb), 2022
Serrano-Contreras JI, Meléndez-Camargo ME, Márquez-Flores YK, Soria-Serrano MP, Campos-Aldrete ME.   +4 more
europepmc   +1 more source

Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines. [PDF]

RSC Adv, 2022
Zhou Z, Luo D, Li G, Yang Z, Cui L, Yang W.   +5 more
europepmc   +1 more source