Results 1 to 10 of about 81,920,088 (159)

An Efficient Synthesis of Imidazo[1,2-a]pyridines

, 2019
Naresuan University Journal: Science and Technology, 27, 3, 43 ...
Wichai, Uthai, Paengphua, Piyawat, Chancharunee, Sirirat   +2 more
openaire   +2 more sources

Recent Advances in Visible Light-Induced C-H Functionalization of Imidazo[1,2-a]pyridines. [PDF]

Molecules
The imidazo[1,2-a]pyridine skeleton is widely present in many natural products and pharmaceutical agents. Due to its impressive and significant biological activities, such as analgesic, anti-tumor, antiosteoporosis, and anxiolytic properties, the ...
Gao J, Fu X, Yang K, Liu Z.
europepmc   +2 more sources

Iron-Catalyzed Sulfonylmethylation of Imidazo[1,2-α]pyridines with N,N-Dimethylacetamide and Sodium Sulfinates. [PDF]

Molecules
Functionalized imidazo[1,2-α]pyridines are important scaffolds in pharmaceuticals. Herein, we present an efficient 3-sulfonylmethylation protocol for imidazo[1,2-α]pyridines by sodium sulfinates in DMA and H2O (2:1) via an FeCl3-catalyzed ...
Sun S, Ye H, Liu H, Li J, Bi X.
europepmc   +2 more sources

One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction. [PDF]

Beilstein J Org Chem, 2016
A novel three-component reaction has been developed to assemble biologically and pharmaceutically important tetracyclic fused imidazo[1,2-a]pyridines in a one-pot fashion utilizing readily available 2-aminopyridines, isatins and isocyanides.
Yang B, Tao C, Shao T, Gong J, Che C.
europepmc   +2 more sources

C₃-Alkylation of Imidazo[1,2-a]pyridines via Three-Component Aza-Friedel-Crafts Reaction Catalyzed by Y(OTf)₃. [PDF]

Molecules
As an important class of nitrogen-containing fused heterocyclic compounds, imidazo[1,2-a]pyridines often exhibit significant biological activities, such as analgesic, anticancer, antiosteoporosis, anxiolytic, etc.
Yang K, Chen CB, Liu ZW, Li ZL, Zeng Y, Wang ZY.   +5 more
europepmc   +2 more sources

PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES. 63. UNEXPECTED FORMATION OF THIENO[3 ',4 ':4,5]IMIDAZO[1,2-a]-PYRIDINES [PDF]

, 2008
The alkaline treatment and dehydrogenation of pyridinium salts, obtainable from the S-alkylation of 3,5-dimethylpyridinium 2-alkylthio-1-cyano2-thioxoethylides with some phenacyl bromides, afforded unexpected heterocycles, 3-alkylthio-1-arylcarbonyl-6,8 ...
Suga, H, Izumita, A, Kakehi, A, Abe, T   +3 more
core   +2 more sources

Imidazo(1,2-a)pyridines. II. Ozonolysis of Imidazo(1,2-a)pyridines and Synthesis of Cardiotonic Agents.

Chemical and Pharmaceutical Bulletin, 1992
The metabolite of loprinone (E-1020) in dogs, 5-(2-aminopyridin-5-yl)-1, 2-dihydro-6-methyl-2-oxo-3-pyridine-carbonitrile (9), was prepared via ozonolysis of imidazo[1, 2-α]pyridinylpyridines and evaluated for positive inotropic activity. Its potency was less than that of loprinone and milrinone.
YAMANAKA, Motosuke, SUDA, Shinji, YONEDA, Naoki, OHHRA, Hideto   +3 more
openaire   +3 more sources

Identification of novel Imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB [PDF]

, 2012
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB ...
Fernández, Raquel, Nicholas J Loman, Besra, Gurdyal S., Ballell, L, Raquel Fernández, Pallen, Mark J., Abrahams, Katherine A, Loman, Nicholas J., Abrahams, Katherine A., Spivey, VL, Constantinidou Chrystala, Mark J Pallen, Remuiñán, Modesto J, Cox, Jonathan A G, Abrahams Katherine A., Loman, Nicholas J, Carlos Alemparte, Lluis Ballell, Cox Jonathan A. G., Loman, NJ, Besra, GS, Constantinidou, Chrystala, Alemparte Carlos, Pallen, Mark J, Besra, Gurdyal S; id_orcid, Abrahams, KA, Remuiñán, Modesto J., Besra Gurdyal S., Remuiñán Modesto J., Vickey L Spivey, Chrystala Constantinidou, Pallen, MJ, Barros, D, Loman Nicholas J., Ballell, Lluis, Fernández, R, Alemparte, Carlos, Cox, Jonathan A. G., Cox, JA, Modesto J Remuiñán, Barros David, Jonathan A G Cox, Gurdyal S Besra, Fernández Raquel, Spivey, Vickey L., David Barros, Constantinidou, C, Ballell Lluis, Spivey Vickey L., Barros, David, Spivey, Vickey L, Pallen Mark J., Remuiñán, MJ, Alemparte, C, Katherine A Abrahams   +54 more
core   +1 more source

Phosphorylated imidazo[1,2‐a]pyridines

Heteroatom Chemistry, 1995
AbstractThe reaction of phosphorus(III) halides with imidazo[1,2‐a]pyridines in the presence of bases leads to the formation of 3‐phosphorylated imidazo[1,2‐a]pyridines. The reaction proceeds in high yield and requires no catalysts.In the compounds obtained, in contrast to phosphorylated indolizines, the phosphorus–heterocycle bond is stable and not ...
Andrew A. Tolmachev, Alexander A. Yurchenko, Ernest S. Kozlov, Anatoliy S. Merkulov, Marina G. Semenova, Aleksander M. Pinchuk   +5 more
openaire   +1 more source

Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt [PDF]

Bioorganic & Medicinal Chemistry Letters, 2014
We report the design, synthesis, and biological evaluation of imidazopyridine-based peptidomimetics based on the substrate consensus sequence of Akt, an AGC family serine/threonine kinase hyperactivated in over 50% of human tumors. Our ligand-based approach led to the identification of novel substrate mimetic inhibitors of Akt1 featuring an unnatural ...
Young B, Kim, Chang Won, Kang, Sujeewa, Ranatunga, Hua, Yang, Said M, Sebti, Juan R, Del Valle   +5 more
openaire   +2 more sources