Results 1 to 10 of about 21,817 (300)

Study of acute toxicity, endothelial- and cardioprotective properties of phenolic and thiophenolic derivatives of 2H-imidazoles

Фармация и фармакология (Пятигорск)
The aim. To study the acute toxicity, endothelial- and cardioprotective properties of phenolic and thiophenolic derivatives of 2H-imidazoles.Materials and methods.
O. A. Puchenkova, O. V. Shheblykina, D. A. Kostina, A. A. Bolgov, P. R. Lebedev, V. V. Molchanov, T. G. Pokrovskaya, M. V. Korokin, E. A. Nikiforov, N. F. Vaskina, T. A. Idrisov, T. D. Moseev, V. V. Melekhin, M. V. Varaksin, V. N. Charushin, O. N. Chupakhin   +15 more
doaj   +1 more source

Synthesis of Heteroaromatic Compounds by Oxidative Aromatization Using an Activated Carbon/Molecular Oxygen System

Molecules, 2009
A variety of heteroaromatic compounds, such as substituted pyridines, pyrazoles, indoles, 2-substituted imidazoles, 2-substituted imidazoles, 2-arylbenzazoles and pyrimidin-2(1H)-ones are synthesized by oxidative aromatization using the activated carbon ...
Masahiko Hayashi, Yuka Kawashita
doaj   +1 more source

Synthesis of 3-[2-(1H-imidazol-2-yl)alkyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2018
Promising biologically active substances are derivatives of imidazole and quinazoline, which are part of the structure of known antifungal drugs and substances with anti-TB and antimicrobial activity.
O. A. Zavada, O. V. Tkachenko, I. O. Zhuravel   +2 more
doaj   +1 more source

Pharmacokinetics of imidazole antimycotics [PDF]

Postgraduate Medical Journal, 1979
Summary According to data on the imidazole antimycotics at present on the market, none of these products satisfactorily fills the gaps which exist in the treatment for mycoses of internal organs, although they have brought considerable progress in the topical treatment of mycoses.
openaire   +2 more sources

Synthesis of imidazole derivatives in the last 5 years: An update

Heterocyclic Communications
Imidazole and its derivatives possess remarkable versatility, finding applications in medicine, synthetic chemistry, and industry. This review explores the latest advancements observed over the last few years (2018–2022), focusing on diverse ...
Devi Mayanglambam Maneeta, Devi Keisham Subharani, Singh Okram Mukherjee, Singh Thokchom Prasanta   +3 more
doaj   +1 more source

Nuclear Quadrupole Resonance Spectroscopy: Tautomerism and Structure of Functional Azoles

Crystals, 2019
The Nuclear Quadrupole Resonance spectroscopy data of functionalized azoles (imidazoles, triazoles and corresponding benzazoles) are reviewed and critically discussed. The possibility of studying the tautomerism of azoles by the NQR method is considered.
Lyudmila I. Larina
doaj   +1 more source

Axitinib, cabozantinib, everolimus, nivolumab, sunitinib and best supportive care in previously treated renal cell carcinoma: a systematic review and economic evaluation

Health Technology Assessment, 2018
Background: Several therapies have recently been approved for use in the NHS for pretreated advanced or metastatic renal cell carcinoma (amRCC), but there is a lack of comparative evidence to guide decisions between them.
Steve J Edwards, Victoria Wakefield, Peter Cain, Charlotta Karner, Kayleigh Kew, Mariana Bacelar, Natalie Masento, Fatima Salih   +7 more
doaj   +1 more source

An overview of structurally diversified anticonvulsant agents

Acta Pharmaceutica, 2019
There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions.
Al-Otaibi Faisal
doaj   +1 more source

Ketoconazole

ARS Medica, 2017
Sin ...
Guillermo Acuña L.
doaj  

Generation of multimillion chemical space based on the parallel Groebke–Blackburn–Bienaymé reaction

Beilstein Journal of Organic Chemistry
Parallel Groebke–Blackburn–Bienaymé reaction was evaluated as a source of multimillion chemically accessible chemical space. Two most popular classical protocols involving the use of Sc(OTf)3 and TsOH as the catalysts were tested on a broad substrate ...
Evgen V. Govor, Vasyl Naumchyk, Ihor Nestorak, Dmytro S. Radchenko, Dmytro Dudenko, Yurii S. Moroz, Olexiy D. Kachkovsky, Oleksandr O. Grygorenko   +7 more
doaj   +1 more source