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Environmentally Friendly Synthesis of Polysubstituted Pyrroles in Ionic Liquid via Gold-Catalyzed Propargylic Substitution/Hydration/Amination/Cycloisomerization Sequence [PDF]

Molecules
An environmentally friendly synthesis of polysubstituted pyrroles in ionic liquid was achieved via a gold-catalyzed propargylic substitution/hydration/amination/cycloisomerization sequence. Treatment of propargylic alcohols, 1,3-dicarbonyl compounds, and
Hitomi Chiaki, Yukinori Umezawa, Yoshimitsu Hashimoto, Nobuyoshi Morita   +3 more
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Regioselective Stepwise Synthesis of Unsymmetrical 1,2,5-Triarylpyrroles via Palladium-Catalyzed Decarboxylative Cross-Coupling and C–H Arylation [PDF]

Molecules
Pyrrole derivatives are natural organic molecules that are important to the pharmaceutical industry due to their occurrence in nature and their use in a wide range of medical applications. In general, non-symmetric, 1,2,5-triaryl-substituted pyrroles are
Cindy Buonomano, Stephanie Patterson, Judith Sorel Ngou, Cynthia Messina, Sarah Taylor, François Bilodeau, Pat Forgione   +6 more
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Recent advances in the syntheses of pyrroles

Green Synthesis and Catalysis, 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient building blocks are developed and these synthons ...
Tao Shi, Gaofeng Yin, Xiaodong Wang, Yongxia Xiong, Yan Peng, Shuang Li, Yaofu Zeng, Zhen Wang   +7 more
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Fused Pyrroles in Cholestane and Norcholestane Side Chains: Acaricidal and Plant Growth-Promoting Effects

Molecules, 2022
Herein, we describe the synthesis and characterization of fused pyrroles in cholestane and norcholestane side chains derived from kryptogenin and diosgenin, respectively.
María G. De los Santos, Marcos Cua-Basulto, Anallely Huepalcalco, Wendy Delit, Jesús Sandoval-Ramírez, Adolfo López-Torres, Esaú Ruiz-Sánchez, María A. Fernández-Herrera   +7 more
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A green protocol for the synthesis of N-aryl pyrroles: A modified Clauson-Kaas approach using zinc catalyst

Results in Chemistry, 2022
The first zinc-catalyzed simple and convenient protocol for the synthesis of N-substituted pyrroles through a modified Clauson-Kaas reaction without co-catalyst, ligand, base and solvent has been described.
C.M.A. Afsina, K.R. Rohit, G. Anilkumar
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An Easy Synthesis of Monofluorinated Derivatives of Pyrroles from β-Fluoro-β-Nitrostyrenes

Molecules, 2021
The catalyst-free conjugate addition of pyrroles to β-Fluoro-β-nitrostyrenes was investigated. The reaction was found to proceed under solvent-free conditions to form 2-(2-Fluoro-2-nitro-1-arylethyl)-1H-pyrroles.
Alexander S. Aldoshin, Andrey A. Tabolin, Sema L. Ioffe, Valentine G. Nenajdenko   +3 more
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Diabetes mellitus is associated with elevated urinary pyrrole markers of γ-diketones known to cause axonal neuropathy

BMJ Open Diabetes Research & Care, 2020
Introduction Progressive distal symmetrical axonal neuropathy, a complication of diabetes mellitus (DM), has an unknown cause. Normal physiological metabolism and diabetic dysmetabolism are associated with the generation of γ-diketones.
Wenting Feng, Dafeng Lin, Xifei Yang, Peter Spencer   +3 more
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Synthesis of N-perfluoroalkyl-3,4-disubstituted pyrroles by rhodium-catalyzed transannulation of N-fluoroalkyl-1,2,3-triazoles with terminal alkynes

Beilstein Journal of Organic Chemistry, 2021
The rhodium-catalyzed transannulation of N-perfluoroalkyl-1,2,3-triazoles with aromatic and aliphatic terminal alkynes under microwave heating conditions afforded N-perfluoroalkyl-3,4-disubstituted pyrroles (major products) and N-fluoroalkyl-2,4 ...
Olga Bakhanovich, Viktor Khutorianskyi, Vladimir Motornov, Petr Beier   +3 more
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Selectively reductive amination of levulinic acid with aryl amines to N-substituted aryl pyrroles

Green Energy & Environment, 2023
Synthesizing nitrogen (N)-containing molecules from biomass derivatives is a new strategy for production of this kind of chemicals. Herein, for the first time we present the synthesis of N-substituted aryl pyrroles via reductive amination/cyclization of ...
Cailing Wu, Mengjie Lou, Mingming Sun, Huiyong Wang, Zhiyong Li, Jikuan Qiu, Jianji Wang, Zhimin Liu   +7 more
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Atom Economical Multi-Substituted Pyrrole Synthesis from Aziridine

Molecules, 2022
Multi-substituted pyrroles are synthesized from regiospecific aziridine ring-opening and subsequent intramolecular cyclization with a carbonyl group at the γ-position in the presence of Lewis acid or protic acid.
Lingamurthy Macha, Ranjith Jala, Sang-Yun Na, Hyun-Joon Ha   +3 more
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