Results 11 to 20 of about 18,845 (239)
Molecules, 2000 A stepwise synthesis of a-unsubstituted pyrroles with desired substituents in the b-positions of the ring has been devised.
O. A. Golubchicov +2 more
doaj +2 more sources
Molecules, 2023 An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation.
Xue Li +6 more
doaj +1 more source
(E)-1-(3-Benzoyl-4-phenyl-1H-pyrrol-1-yl)-3-phenylprop-2-en-1-one
Molbank, 2022 Over the last decade, there has been an increasing effort to fight inflammatory conditions establishing new multitarget approaches. Chronic inflammation is implicated in many multifactorial diseases, constituting a great economic burden and a chronic ...
Viola Noti, Dimitra Hadjipavlou-Litina
doaj +1 more source
Журнал органічної та фармацевтичної хімії, 2020 Aim. To study the synthetic potential of cyclization of N-(β-polyfluoroacyl)vinyl derivatives of proline and N-substituted glycines into polyfluoroalkyl pyrroles, which are useful intermediates to fluorinated pyrrolidine alkaloids.
Anton A. Klipkov +3 more
doaj +1 more source
Technology for the production of disubstituted pyrroles [PDF]
E3S Web of Conferences, 2023 In this work, we studied the catalytic synthesis of pyrrole and their derivatives from ketoximes and acetylene in the liquid phase under normal conditions in the presence of homogeneous catalysts.
Safarov Megli Djumayevich
doaj +1 more source
Selectively reductive amination of levulinic acid with aryl amines to N-substituted aryl pyrroles
Green Energy & Environment, 2023 Synthesizing nitrogen (N)-containing molecules from biomass derivatives is a new strategy for production of this kind of chemicals. Herein, for the first time we present the synthesis of N-substituted aryl pyrroles via reductive amination/cyclization of ...
Cailing Wu +7 more
doaj +1 more source
Atom Economical Multi-Substituted Pyrrole Synthesis from Aziridine
Molecules, 2022 Multi-substituted pyrroles are synthesized from regiospecific aziridine ring-opening and subsequent intramolecular cyclization with a carbonyl group at the γ-position in the presence of Lewis acid or protic acid.
Lingamurthy Macha +3 more
doaj +1 more source
Effect of Substituents of Cerium Pyrazolates and Pyrrolates on Carbon Dioxide Activation
Molecules, 2021 Homoleptic ceric pyrazolates (pz) Ce(RR’pz)4 (R = R’ = tBu; R = R’ = Ph; R = tBu, R’ = Me) were synthesized by the protonolysis reaction of Ce[N(SiHMe2)2]4 with the corresponding pyrazole derivative.
Uwe Bayer +4 more
doaj +1 more source
Cancer Medicine, 2023 Background Activating mutations of the KRAS occurs in >90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, direct pharmacological targeting of the activated KRAS protein has been challenging.
Akiko Tsujimoto +10 more
doaj +1 more source
Pharmaceuticals, 2021 Nocodazole is an antineoplastic agent that exerts its effects by depolymerizing microtubules. Herein we report a structural analog of nocodazole, a (1H-pyrrol-1-yl)methyl-1H-benzoimidazole carbamate ester derivative, named RDS 60.
Alice Nicolai +14 more
doaj +1 more source