Results 41 to 50 of about 17,074 (296)

[3+3]-Annulation of Cyclic Nitronates with Vinyl Diazoacetates: Diastereoselective Synthesis of Partially Saturated [1,2]Oxazino[2,3-b][1,2]oxazines and Their Base-Promoted Ring Contraction to Pyrrolo[1,2-b][1,2]oxazine Derivatives

Molecules, 2023
A rhodium(II)-catalyzed reaction of cyclic nitronates (5,6-dihydro-4H-1,2-oxazine N-oxides) with vinyl diazoacetates proceeds as a [3+3]-annulation producing bicyclic unsaturated nitroso acetals (4a,5,6,7-tetrahydro-2H-[1,2]oxazino[2,3-b][1,2]oxazines ...
Yulia A. Antonova, Yulia V. Nelyubina, Sema L. Ioffe, Andrey A. Tabolin   +3 more
doaj   +1 more source

Synthesis of Pentasubstituted 2-Aryl Pyrroles from Boryl and Stannyl Alkynes via One-Pot Sequential Ti-Catalyzed [2+2+1] Pyrrole Synthesis/Cross Coupling Reactions

, 2020
An efficient catalytic synthesis of 2-heteroatom-substituted (9-BBN or SnR3) pyrroles via Ti-catalyzed [2+2+1] heterocoupling of heteroatom-substituted alkynes is reported. The resulting 2-boryl substituted pyrroles can then be used
Ian, Tonks, Channing, Klein, Yukun, Cheng   +2 more
core   +1 more source

Antifungal Activity of Fibrate-Based Compounds and Substituted Pyrroles That Inhibit the Enzyme 3-Hydroxy-methyl-glutaryl-CoA Reductase of Candida glabrata (CgHMGR), Thus Decreasing Yeast Viability and Ergosterol Synthesis

Microbiology Spectrum, 2022
Due to the emergence of multidrug-resistant strains of yeasts belonging to the Candida genus, there is an urgent need to discover antifungal agents directed at alternative molecular targets.
Damián A. Madrigal-Aguilar, Adilene Gonzalez-Silva, Blanca Rosales-Acosta, Celia Bautista-Crescencio, Jossué Ortiz-Álvarez, Carlos H. Escalante, Jaime Sánchez-Navarrete, César Hernández-Rodríguez, Germán Chamorro-Cevallos, Joaquín Tamariz, Lourdes Villa-Tanaca   +10 more
doaj   +1 more source

Synthesis of Tetrasubstituted Pyrroles from Terminal Alkynes and Imines

, 2013
Tetrasubstituted pyrroles can be obtained via the reaction of terminal alkynes and Imines using (BuLi)-Bu-n as the base In one step with high chemoselectivity (method 1).
Wu, Fan, Wan, Boshun, Hu, Yancheng, 万伯顺, Wang, Dongping, Wang, Chunxiang   +5 more
core   +1 more source

Electrochemically Induced N-Alkylation of Pyrroles

, 1999
Electrochemically generated tetraethylammonium peroxy- corresponding N-alkylated pyrroles in high yields. C- Alkylated pyrroles have not been isolated in any casedicarbonate (TEAPC) and tetraethylammonium carbonate (TEAC) react under very mild ...
FEROCI, Marta, L. ROSSI, INESI, ACHILLE, G. SLEITER   +3 more
core   +2 more sources

The Synthesis of Pyrroles from Nitroolefins

Журнал органічної та фармацевтичної хімії
The synthesis of pyrroles occupies a key place in synthetic organic chemistry due to the numerous biological properties of pyrrole derivatives, in particular antimicrobial, antibacterial, antifungal, antimalarial, anticancer activities, etc.
Andrii H. Hotynchan, Olena M. Kovtun, Yuriy P. Kovtun   +2 more
doaj   +1 more source

Cycloaddition of Benzyne with Alkoxy-Substituted Pyrroline-N-oxides­: Unexpected Rearrangement to an N-Phenylpyrrole

SynOpen, 2018
Reaction of enantiopure 3,4-dialkoxy-pyrroline N-oxides with benzyne affords the expected tetrahydrobenzo[d]pyrrolo[1,2-b]isoxazoles along with an unexpected 2,3-disubstitued-N-phenyl-pyrrole derived from an unprecedented rearrangement of the adduct of ...
Franca M. Cordero, Bhushan B. Khairnar, Anna Ranzenigo, Alberto Brandi   +3 more
doaj   +1 more source

Recent Strides in the Transition Metal-Free Cross-Coupling of Haloacetylenes with Electron-Rich Heterocycles in Solid Media

Molecules, 2020
The publications covering new, transition metal-free cross-coupling reactions of pyrroles with electrophilic haloacetylenes in solid medium of metal oxides and salts to regioselectively afford 2-ethynylpyrroles are discussed.
Lyubov’ N. Sobenina, Boris A. Trofimov
doaj   +1 more source

Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives

Molecules, 2015
Within the framework of our attempts to synthesize pleiotropic anti-inflammatory agents, we have synthesized some chalcones and their corresponding 3,4-pyrrolyl derivatives. Chalcones constitute a class of compounds with high biological impact.
Markella Konstantinidou, Alice Gkermani, Dimitra Hadjipavlou-Litina   +2 more
doaj   +1 more source

Tetrasubstituted Pyrrole Derivative Mimetics of Protein–Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells

Molecules, 2023
A new series of tetrasubstituted pyrrole derivatives (TSPs) was synthesized based on a previously developed hypothesis on their ability to mimic hydrophobic protein motifs.
Marco Persico, Paola Galatello, Maria Grazia Ferraro, Carlo Irace, Marialuisa Piccolo, Avazbek Abduvakhidov, Oleh Tkachuk, Maria Luisa d’Aulisio Garigliota, Pietro Campiglia, Patrizia Iannece, Michela Varra, Anna Ramunno, Caterina Fattorusso   +12 more
doaj   +1 more source