Results 41 to 50 of about 26,582 (202)

The Synthesis of Pyrroles from Nitroolefins

Журнал органічної та фармацевтичної хімії
The synthesis of pyrroles occupies a key place in synthetic organic chemistry due to the numerous biological properties of pyrrole derivatives, in particular antimicrobial, antibacterial, antifungal, antimalarial, anticancer activities, etc.
Andrii H. Hotynchan, Olena M. Kovtun, Yuriy P. Kovtun   +2 more
doaj   +1 more source

Cycloaddition of Benzyne with Alkoxy-Substituted Pyrroline-N-oxides­: Unexpected Rearrangement to an N-Phenylpyrrole

SynOpen, 2018
Reaction of enantiopure 3,4-dialkoxy-pyrroline N-oxides with benzyne affords the expected tetrahydrobenzo[d]pyrrolo[1,2-b]isoxazoles along with an unexpected 2,3-disubstitued-N-phenyl-pyrrole derived from an unprecedented rearrangement of the adduct of ...
Franca M. Cordero, Bhushan B. Khairnar, Anna Ranzenigo, Alberto Brandi   +3 more
doaj   +1 more source

Recent Strides in the Transition Metal-Free Cross-Coupling of Haloacetylenes with Electron-Rich Heterocycles in Solid Media

Molecules, 2020
The publications covering new, transition metal-free cross-coupling reactions of pyrroles with electrophilic haloacetylenes in solid medium of metal oxides and salts to regioselectively afford 2-ethynylpyrroles are discussed.
Lyubov’ N. Sobenina, Boris A. Trofimov
doaj   +1 more source

Antifungal Activity of Fibrate-Based Compounds and Substituted Pyrroles That Inhibit the Enzyme 3-Hydroxy-methyl-glutaryl-CoA Reductase of Candida glabrata (CgHMGR), Thus Decreasing Yeast Viability and Ergosterol Synthesis

Microbiology Spectrum, 2022
Due to the emergence of multidrug-resistant strains of yeasts belonging to the Candida genus, there is an urgent need to discover antifungal agents directed at alternative molecular targets.
Damián A. Madrigal-Aguilar, Adilene Gonzalez-Silva, Blanca Rosales-Acosta, Celia Bautista-Crescencio, Jossué Ortiz-Álvarez, Carlos H. Escalante, Jaime Sánchez-Navarrete, César Hernández-Rodríguez, Germán Chamorro-Cevallos, Joaquín Tamariz, Lourdes Villa-Tanaca   +10 more
doaj   +1 more source

Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives

Molecules, 2015
Within the framework of our attempts to synthesize pleiotropic anti-inflammatory agents, we have synthesized some chalcones and their corresponding 3,4-pyrrolyl derivatives. Chalcones constitute a class of compounds with high biological impact.
Markella Konstantinidou, Alice Gkermani, Dimitra Hadjipavlou-Litina   +2 more
doaj   +1 more source

The structures of Micrococcus lysodeikticus catalase, its ferryl intermediate (compound II) and NADPH complex [PDF]

, 2002
The crystal structure of the bacterial catalase from Micrococcus lysodeikticus has been refined using the gene-derived sequence both at 0.88 Angstrom resolution using data recorded at 110 K and at 1.5 Angstrom resolution with room-temperature data.
Antson, A A, Barynin, V V, Brannigan, J A, Dauter, Z, Dodson, G G, Grebenko, A I, Melik-Adamyan, W R, Murshudov, G N, Wilson, K S   +8 more
core   +1 more source

Synthetic Approaches to the Lamellarins—A Comprehensive Review

Marine Drugs, 2014
The present review discusses the known synthetic routes to the lamellarin alkaloids published until 2014. It begins with syntheses of the structurally simpler type-II lamellarins and then focuses on the larger class of the 5,6-saturated and -unsaturated ...
Dennis Imbri, Johannes Tauber, Till Opatz   +2 more
doaj   +1 more source

Tetrasubstituted Pyrrole Derivative Mimetics of Protein–Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells

Molecules, 2023
A new series of tetrasubstituted pyrrole derivatives (TSPs) was synthesized based on a previously developed hypothesis on their ability to mimic hydrophobic protein motifs.
Marco Persico, Paola Galatello, Maria Grazia Ferraro, Carlo Irace, Marialuisa Piccolo, Avazbek Abduvakhidov, Oleh Tkachuk, Maria Luisa d’Aulisio Garigliota, Pietro Campiglia, Patrizia Iannece, Michela Varra, Anna Ramunno, Caterina Fattorusso   +12 more
doaj   +1 more source

Synthesis and Anti-Tuberculosis Activity of Substituted 3,4-(dicoumarin-3-yl)-2,5-diphenyl Furans and Pyrroles

Engineering Proceedings, 2022
Increasing rates of multi-drug resistant (MDR) and extremely-drug resistant (XDR) cases of tuberculosis (TB) strains are alarming, and eventually hampered an effective control of the pathogenic disease. In the present study, nine derivatives of 2,3-bis(2-
Bhagwat Jadhav, Ramesh Yamgar, Suraj N. Mali   +2 more
doaj   +1 more source

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D., Porco, John A., Stephenson, Corey R.J.   +2 more
core   +2 more sources