Results 21 to 30 of about 16,360 (266)

Lower micromolar activity of the antifungal imidazoles on the bacterial-type bifunctional aldehyde/alcohol dehydrogenase (AdhE) in Cryptosporidium parvum and in vitro efficacy against the zoonotic parasite

International Journal for Parasitology: Drugs and Drug Resistance
Cryptosporidium parvum is a waterborne and foodborne zoonotic protozoan parasite, a causative agent of moderate to severe diarrheal diseases in humans and animals. However, fully effective treatments are unavailable for medical and veterinary uses. There
Haichuan Chen, Dongqiang Wang, Chenchen Wang, Peng Jiang, Mingxiao Liu, Jigang Yin, Yonglan Yu   +6 more
doaj   +1 more source

The Reaction of Aminonitriles with Aminothiols: A Way to Thiol-Containing Peptides and Nitrogen Heterocycles in the Primitive Earth Ocean

Life, 2018
The Strecker reaction of aldehydes with ammonia and hydrogen cyanide first leads to α-aminonitriles, which are then hydrolyzed to α-amino acids.
Ibrahim Shalayel, Seydou Coulibaly, Kieu Dung Ly, Anne Milet, Yannick Vallée   +4 more
doaj   +1 more source

Magnesium and imidazole propionate

Clinical Nutrition ESPEN, 2021
Circulating levels of imidazole propionate (ImP), a microbial metabolite of histidine, were higher in participants with type 2 diabetes (T2D) compared to those without and also induced insulin resistance. We hypothesize that low intake of magnesium (Mg) and/or low body Mg status in humans may lead to low Mg concentrations in gut microbiota, and, in ...
Lei Fan, Danxia Yu, Xiangzhu Zhu, Xiang Huang, Harvey J. Murff, M.Andrea Azcarate-Peril, Martha J. Shrubsole, Qi Dai   +7 more
openaire   +3 more sources

Identification and characterization of aging products in the glyoxal/ammonium sulfate system – implications for light-absorbing material in atmospheric aerosols [PDF]

Atmospheric Chemistry and Physics, 2012
In this study we report the identification of bicyclic imidazoles in aqueous aerosol mimics using HPLC-ESI-MS/MS. 2,2'-Biimidazole was identified to be a major contributor to the 280 nm absorbance band observed in mixtures of glyoxal and ammonium sulfate,
C. J. Kampf, R. Jakob, T. Hoffmann
doaj   +1 more source

Solvothermal One-Pot Synthesis of a New Family of Chiral [Fe₄O₄]-Cubane Clusters with Redox Active Cores

Magnetochemistry, 2022
The two achiral ligands tris(1-methyl-1H-imidazol-2-yl)methanol ((mim)3COH) and bis(1-methyl-1H-imidazol-2-yl)(3-methylpyridin-2-yl)methanol ((mim)2(mpy)COH) form on reaction with Fe(BF4)2∙6H2O, the octahedral low-spin complexes [Fe((mim)3COH)2](BF4)2 ...
Marco Seifried, Frieda M. Kapsamer, Michael Reissner, Jan M. Welch, Gerald Giester, Danny Müller, Peter Weinberger   +6 more
doaj   +1 more source

Current progress in the synthesis of imidazoles and their derivatives via the use of green tools

Heterocyclic Communications
Imidazoles have a unique position in heterocyclic chemistry as these constitute the basic framework of several bio-molecules. Thus, increasing research is being carried out on the synthesis of imidazoles and their derivatives, mainly because of the ...
Saha Debasree, Mukhopadhyay Chhanda
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Preparation and Characterization of NiCoFe2O4 Nanoparticles as an Effective Catalyst for the Synthesis of Trisubstituted Imidazole Derivatives Under Solvent-free Conditions

Acta Chimica Slovenica, 2022
In this study, NiCoFe2O4 nanoparticles were prepared and used as a reactive catalyst for the synthesis of trisubstituted imidazoles. The multicomponent reactions of aromatic aldehydes, benzil and ammonium acetate were carried out under solvent-free and ...
Leila Hemmesi, Hossein Naeimi
doaj   +1 more source

Metabolism of Imidazole by a Pseudomonad [PDF]

Journal of Bacteriology, 1971
Intermediates formed during the microbial degradation of imidazole, namely 4(5)-imidazolone, formiminoglycine, and possibly glycine, are similar to those formed during metabolism of imidazole derivatives.
H G, Oien, L D, Wright
openaire   +2 more sources