Results 11 to 20 of about 30,850 (304)
Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models [PDF]
, 2017 Burkholderia cenocepacia is an opportunistic pathogen responsible for life-threatening infections in cystic fibrosis patients. B. cenocepacia is extremely resistant towards antibiotics and therapy is complicated by its ability to form biofilms.
Brackman, Gilles +10 more
core +4 more sources
Cancer Medicine, 2023 Background Activating mutations of the KRAS occurs in >90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, direct pharmacological targeting of the activated KRAS protein has been challenging.
Akiko Tsujimoto +10 more
doaj +1 more source
Structure and Magnetic Properties of a 1D Alternating Cu(II) Monomer―Paddlewheel Chain [PDF]
, 2018 One-dimensional metal–organic coordination polymers make up a class of compounds with potential towards the development of practical, new magnetic materials.
Dawe, Louise N. +2 more
core +3 more sources
Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates. [PDF]
, 2012 The imidazoles 1a–g add to the CC-double bond of the iminium ion 2 with rate constants as predicted by the equation log k = sN(N + E). Unfavourable proton shifts from the imidazolium unit to the enamine fragment in the adduct 3 account for the failure of
Ahrendt +33 more
core +1 more source
The Structure of Biologically Active Functionalized Azoles: NMR Spectroscopy and Quantum Chemistry
Magnetochemistry, 2022 This review summarizes the data on the stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) and related compounds obtained by multipulse and multinuclear 1H, 13C, 15N NMR spectroscopy and quantum
Lyudmila I. Larina
doaj +1 more source
Bulletin of the Chemical Society of Ethiopia, 2017 A simple and efficient method for one-pot synthesis of lophine derivatives (2,4,5-trisubstituted imidazoles) by using the benzyltriphenylphosphonium chloride (BTPPC), as a catalyst, under solvent-free conditions is described.
M. Alikarami, M. Amozad
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2020 We report that phenacyl azides are key compounds for a regiodivergent synthesis of valuable, functionalized imidazole (32–98% yield) and pyrimidine derivatives (45–88% yield), with a broad substrate scope, when using deep eutectic solvents [choline ...
Paola Vitale +5 more
doaj +1 more source
Molecules, 2020 The rapid growth of serious infections caused by antibiotic resistant bacteria, especially the nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists and is one of the world’s major health problems.
Renzo Rossi, Maurizio Ciofalo
doaj +1 more source
The Octarepeat Domain of the Prion Protein Binds Cu(II) with Three Distinct Coordination Modes at pH 7.4 [PDF]
, 2005 The prion protein (PrP) binds Cu2+ in its N-terminal octarepeat domain. This unusual domain is comprised of four or more tandem repeats of the fundamental sequence PHGGGWGQ.
Antholine, William E. +9 more
core +3 more sources
Analysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbent [PDF]
, 2017 This paper reports the MEPS-HPLC-DAD method for the simultaneous determination of 12 azole drugs (bifonazole, butoconazole, clotrimazole, econazole, itraconazole, ketoconazole, miconazole, posaconazole, ravuconazole, terconazole, tioconazole and ...
Bellagamba, Giuseppe +9 more
core +3 more sources