Results 41 to 50 of about 22,275 (301)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Benzylic C–H Oxidation: Recent Advances and Applications in Heterocyclic Synthesis
MoleculesBenzylic C–H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates.
Nonhlelo Majola, Vineet Jeena
doaj +1 more source
Groups of antifungal drugs with role in animal health - Synthesis [PDF]
Medicamentul Veterinar, 2021 Fungal infections are an important part of infectious pathology, their incidence increasing considerably, as a result of the widespread use of antibiotics, corticosteroids, cytostatics and immunosuppressive drugs.
Răzvan F. Moruzi +6 more
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
(4-(Adamantan-1-yl)-1-(isopropyl)-1H-imidazol-2-yl)methanol
Molbank, 2023 (4-(Adamantan-1-yl)-1-(isopropyl)-1H-imidazol-2-yl)methanol was prepared through a five-step process starting from commercially available 1-acetyladamantane.
Ryan B. Gaynor +2 more
doaj +1 more source
New Method for the Synthesis of Diversely Functionalized Imidazoles from N-Acylated α-Aminonitriles
, 2016 A new general method for the synthesis of medicinally important diversely functionalized imidazoles from N-acylated α-aminonitriles has been developed. N-Acylated α-aminonitriles were reacted with triphenylphosphine and carbon tetrahalide to afford 2,4 ...
Jaemoon Lee (1980979) +3 more
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Synthesis of imidazoles promoted by H3PW12O40-amino-functionalized CdFe12O19@SiO2 nanocomposite
Nanocomposites, 2020 H3PW12O40-amino-functionalized CdFe12O19@SiO2 nanocomposite has been applied as an effective nanocatalyst for the preparation of imidazoles by three-component reactions of benzil, ammonium acetate, and benzaldehydes under solvent-free condition ...
Javad Safaei-Ghomi +2 more
doaj +1 more source
, 1999 The influence of lipophilic moieties attached to a 4-1H-imidazole ring on the histamine H3 receptor activity was systematically investigated. Series of 4-(n-alkyl)-1H-imidazoles and 4-(omega-phenylalkyl)-1H-imidazoles were prepared, with an alkyl chain ...
Menge, W M +6 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source