Results 61 to 70 of about 30,850 (304)

Application of Artificial Neural Networks for Predicting Imidazole Derivatives' Antimicrobial Activity against Enterococcus faecalis [PDF]

Farmacja Polska
Artificial neural networks (ANNs) have emerged as a valuable tool in facilitating the design of synthesis and guiding subsequent biological experiments in the systematic exploration for novel antimicrobial agents. In this paper, two multilayer perceptron-
Anna Badura, Łukasz Pałkowski, Alicja Nowaczyk, Marta Poćwiardowska-Głąb, Adam Buciński   +4 more
doaj   +1 more source

Synthesis of novel 6-enaminopurines [PDF]

, 2004
Two different approaches have been used for the synthesis of 6-enaminopurines 6 from 5-amino-4-cyanoformimidoyl imidazoles 1. In the first approach imidazoles 1 were reacted with ethoxymethylenemalononitrile or ethoxymethylenecyanoacetate under mild ...
Booth, Brian L., Carvalho, M. Alice, Proença, M. Fernanda R. P., Zaki, M., Álvares, Yolanda   +4 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Synthesis of Functionalized 1H-Imidazoles via Denitrogenative Transformation of 5-Amino-1,2,3-Triazoles

Molecules
An efficient access to novel 2-substituted 1H-imidazole derivatives was developed based on acid-mediated denitrogenative transformation of 5-amino-1,2,3-triazole derivatives available through dipolar azide−nitrile cycloaddition (DCR).
Pavel S. Gribanov, Anna N. Philippova, Alexander F. Smol’yakov, Diana N. Tukhvatullina, Viktoria A. Vlasova, Maxim A. Topchiy, Andrey F. Asachenko, Sergey N. Osipov   +7 more
doaj   +1 more source

Crystal structure of 1-methyl-2-[(E)-2-(4-methylphenyl)ethenyl]-4-nitro-1H-imidazole

Acta Crystallographica Section E, 2014
In the title molecule, C13H13N3O2, the planes of the benzene and imidazole rings form a dihedral angle of 7.72 (5)°. In the crystal, molecules are linked by weak C—H...N and C—H...O hydrogen bonds, forming layers parallel to (100).
Hayette Alliouche, Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Ali Belfaitah   +4 more
doaj   +1 more source

Substituent-Controllable Cascade Regioselective Annulation of β-Enaminones with N-Sulfonyl Triazoles for Modular Access to Imidazoles and Pyrroles

Molecules, 2023
A controllable synthesis of trisubstituted imidazoles and pyrroles has been developed through rhodium(II)-catalyzed regioselective annulation of N-sulfonyl-1,2,3-trizaoles with β-enaminones.
Hua Wang, Tongtong Zhou, Mengdi Wu, Qingqing Ye, Xinwei He   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Lepidiline-Derived Imidazole-2(3H)-Thiones: (3+2)-Cycloadditions vs. Nucleophilic Additions in Reactions with Fluorinated Nitrile Imines

Molecules
Two series of imidazole-2(3H)-thiones inspired by naturally occurring lepidiline alkaloids, bearing either one or two benzyl-type substituents located at the N(1)/N(3) atoms, respectively, were prepared and examined in reactions with in situ generated C ...
Wiktor K. Poper, Kamil Świątek, Katarzyna Urbaniak, Barbara Olszewska, Marcin Jasiński   +4 more
doaj   +1 more source

One pot Pd(OAc)2-catalysed 2,5-diarylation of imidazoles derivatives [PDF]

, 2014
International audienceThe regioselective 2- or 5-arylation of imidazole derivatives with aryl halides using palladium catalysts has been described in recent years; whereas the arylation at both C2 and C5 carbons of imidazoles in high yields has not been ...
Dixneuf, Pierre H., Doucet, Henri, Soulé, Jean-François, Takfaoui, Abdelilah, Touzani, Rachid, Zhao, Liqin   +5 more
core   +3 more sources

Pharmacokinetics of imidazole antimycotics [PDF]

Postgraduate Medical Journal, 1979
Summary According to data on the imidazole antimycotics at present on the market, none of these products satisfactorily fills the gaps which exist in the treatment for mycoses of internal organs, although they have brought considerable progress in the topical treatment of mycoses.
openaire   +2 more sources