Results 51 to 60 of about 22,275 (301)

Synthesis of Functionalized 1H-Imidazoles via Denitrogenative Transformation of 5-Amino-1,2,3-Triazoles

Molecules
An efficient access to novel 2-substituted 1H-imidazole derivatives was developed based on acid-mediated denitrogenative transformation of 5-amino-1,2,3-triazole derivatives available through dipolar azide−nitrile cycloaddition (DCR).
Pavel S. Gribanov, Anna N. Philippova, Alexander F. Smol’yakov, Diana N. Tukhvatullina, Viktoria A. Vlasova, Maxim A. Topchiy, Andrey F. Asachenko, Sergey N. Osipov   +7 more
doaj   +1 more source

Application of Artificial Neural Networks for Predicting Imidazole Derivatives' Antimicrobial Activity against Enterococcus faecalis [PDF]

Farmacja Polska
Artificial neural networks (ANNs) have emerged as a valuable tool in facilitating the design of synthesis and guiding subsequent biological experiments in the systematic exploration for novel antimicrobial agents. In this paper, two multilayer perceptron-
Anna Badura, Łukasz Pałkowski, Alicja Nowaczyk, Marta Poćwiardowska-Głąb, Adam Buciński   +4 more
doaj   +1 more source

Base-Promoted Annulation of Amidoximes with Alkynes: Simple Access to 2,4-Disubstituted Imidazoles

Molecules, 2020
An efficient construction of imidazole ring by a Cs2CO3-promoted annulation of amidoximes with terminal alkynes in DMSO has been developed. This protocol provides a simple synthetic route with high atom-utilization for the synthesis of 2,4-disubstituted ...
Hina Mehmood, Muhammad Asif Iqbal, Le Lu, Ruimao Hua   +3 more
doaj   +1 more source

Synthesis on templates : Regiospecific synthesis of imidazoles

, 1984
A new, biomimetic template operated strategy has been developed leading to regiospecific synthesis of imidazoles (CHARTS I & II)
Ranganathan, Darshan, Darshan Ranganathan, Farooqui, Firdous, Firdous Farooqui   +3 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Lepidiline-Derived Imidazole-2(3H)-Thiones: (3+2)-Cycloadditions vs. Nucleophilic Additions in Reactions with Fluorinated Nitrile Imines

Molecules
Two series of imidazole-2(3H)-thiones inspired by naturally occurring lepidiline alkaloids, bearing either one or two benzyl-type substituents located at the N(1)/N(3) atoms, respectively, were prepared and examined in reactions with in situ generated C ...
Wiktor K. Poper, Kamil Świątek, Katarzyna Urbaniak, Barbara Olszewska, Marcin Jasiński   +4 more
doaj   +1 more source

Crystal structure of 1-methyl-2-[(E)-2-(4-methylphenyl)ethenyl]-4-nitro-1H-imidazole

Acta Crystallographica Section E, 2014
In the title molecule, C13H13N3O2, the planes of the benzene and imidazole rings form a dihedral angle of 7.72 (5)°. In the crystal, molecules are linked by weak C—H...N and C—H...O hydrogen bonds, forming layers parallel to (100).
Hayette Alliouche, Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Ali Belfaitah   +4 more
doaj   +1 more source

Substituent-Controllable Cascade Regioselective Annulation of β-Enaminones with N-Sulfonyl Triazoles for Modular Access to Imidazoles and Pyrroles

Molecules, 2023
A controllable synthesis of trisubstituted imidazoles and pyrroles has been developed through rhodium(II)-catalyzed regioselective annulation of N-sulfonyl-1,2,3-trizaoles with β-enaminones.
Hua Wang, Tongtong Zhou, Mengdi Wu, Qingqing Ye, Xinwei He   +4 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Highly selective synthesis of 4(5)-aryl-, 2,4(5)-diaryl-, and 4,5-diaryl-1H-imidazoles via Pd-catalyzed direct C-5 arylation of 1-benzyl-1H-imidazole

, 2008
Highly selective, practical, and efficient protocols for the preparation of 4(5)-aryl-1H-imidazoles 2, 2,4(5)-diaryl-1H-imidazoles 3, and 4,5- diaryl-1H-imidazoles 1 are described. A key step of these protocols is the regioselective synthesis of 5-aryl-1-
ROSSI, RENZO, A. Di Fiore, DI FIORE A, MARCHETTI C, C. Marchetti, R. Rossi, CAUTERUCCIO S, BELLINA, FABIO, F. Bellina, S. Cauteruccio   +9 more
core   +1 more source