Results 1 to 10 of about 120,532 (302)

Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery

Pharmaceutics, 2020
To assess the difference in the fate of the antibiotic colistin (COLI) after its pulmonary delivery as a powder or a solution, we developed a COLI powder and evaluated the COLI pharmacokinetic properties in rats after pulmonary administration of the ...
Frédéric Tewes, Julien Brillault, Nicolas Gregoire, Jean-Christophe Olivier, Isabelle Lamarche, Christophe Adier, Anne-Marie Healy, Sandrine Marchand   +7 more
doaj   +1 more source

A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae [PDF]

, 2013
The aim of this study was to explore the mechanisms of resistance against invading Ascaris suum larvae in pigs. Pigs received a low dose of 100 A. suum eggs daily for 14 weeks.
Chiers, Koen, Geldhof, Peter, Masure, Dries, Van Den Broeck, Wim, Vercruysse, Jozef, Vlaminck, Johnny, Wang, Tao   +6 more
core   +15 more sources

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]

, 2011
The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong, Durrant, Jacob D, Gorfe, Alemayehu A, Li, Jikun, McCammon, J Andrew, Oldfield, Eric, Sankovsky, Anna, Zhu, Wei   +7 more
core   +2 more sources

Evolution and Biological Evaluation of Matrinic Derivatives with Amantadine Fragments As New Anti-Influenza Virus Agents

Molecules, 2019
A series of novel tricyclic matrinic derivatives with 11-adamantyl substitution were designed, synthesized, and evaluated for their activities against Influenza A H3N2 virus, based on the privileged structure strategy.
Tianyu Niu, Xiaoqiang Zhao, Jing Jiang, Haiyan Yan, Yinghong Li, Sheng Tang, Yuhuan Li, Danqing Song   +7 more
doaj   +1 more source

Anti-Infective Treatment and Resistance Is Rarely Problematic with Eye Infections

Antibiotics, 2022
The treatment of eye infections is very different than treating other body infections that require systemic anti-infectives. Endophthalmitis, keratitis, conjunctivitis, and other ocular infections are treated with direct injection and with topical drops ...
Regis P. Kowalski, Shannon V. Nayyar, Eric G. Romanowski, Vishal Jhanji   +3 more
doaj   +1 more source

Linking sustainable use policies to novel economic incentives to stimulate antibiotic research and development

Infectious Disease Reports, 2017
There is now global recognition that antibiotic resistance is an emerging public health threat. Policy initiatives are underway to provide concrete suggestions for overcoming important obstacles in the fight against antibiotic resistance, like the ...
Ursula Theuretzbacher, Christine Årdal, Stephan Harbarth   +2 more
doaj   +1 more source

Successful ceftolozane/tazobactam treatment of chronic pulmonary infection with pan‐resistant Pseudomonas aeruginosa [PDF]

, 2015
The treatment of chronic Pseudomonas aeruginosa infections is challenging, with resistance and antibiogram diversity accumulating during successive therapies.
Andrews, Ashish, Boucher, Chandorkar, Juan, Lepak, Livermore, Shlaes, Turton, VanScoy   +9 more
core   +1 more source

Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics [PDF]

, 2009
Novel therapeutic strategies are urgently needed for the treatment of serious diseases caused by viral, bacterial and parasitic infections, because currently used drugs are facing the problem of rapidly emerging resistance.
Bernardini, F, Bisang, C, DeMarco, S J, Gombert, F O, Moehle, K, Obrecht, D, Robinson, J A   +6 more
core   +1 more source

Insights into early stage of antibiotic development in small- and medium-sized enterprises: a survey of targets, costs, and durations

Journal of Pharmaceutical Policy and Practice, 2018
Background Antibiotic innovation has dwindled to dangerously low levels in the past 30 years. Since resistance continues to evolve, this innovation deficit can have perilous consequences on patients.
Christine Årdal, Enrico Baraldi, Ursula Theuretzbacher, Kevin Outterson, Jens Plahte, Francesco Ciabuschi, John-Arne Røttingen   +6 more
doaj   +1 more source

Factors associated with PPSV23 coverage among older adults in Japan: a nationwide community-based survey

BMJ Open, 2019
Objectives The 23-valent pneumococcal polysaccharide vaccine (PPSV23) was included in Japan’s national immunisation programme for older adults in 2014.
Yoshitaka Murakami, Shinichi Kanazu, Tanaz Petigara, Mari Saito Oba, Yuji Nishiwaki, Akira Watanabe   +5 more
doaj   +1 more source