Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents [PDF]
Pharmaceuticals, 2020 This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina +3 more
doaj +6 more sources
Impact of High-Dose Anti-Infective Agents on the Osteogenic Response of Mesenchymal Stem Cells [PDF]
Antibiotics, 2021 Treatment of infected nonunions and severe bone infections is a huge challenge in modern orthopedics. Their treatment routinely includes the use of anti-infective agents. Although frequently used, little is known about their impact on the osteogenesis of
Jakob Hofmann +4 more
doaj +5 more sources
Use of T Cell Mediated Immune Functional Assays for Adjustment of Immunosuppressive or Anti-infective Agents in Solid Organ Transplant Recipients: A Systematic Review [PDF]
Frontiers in Immunology, 2020 Background: Defining the optimal dosage of the immunosuppressive or duration of anti-infective agents is a challenge in solid organ transplant (SOT) recipients.
Omid Rezahosseini +13 more
doaj +5 more sources
Increased prescription rate of anti‐infective agents after diagnosis of myelodysplastic syndromes [PDF]
eJHaem, 2022 The a priori risk for infections in patients with myelodysplastic syndromes (MDS) is unknown. This study examines prescription rates of anti‐infective agents in MDS patients before and after diagnosis, in both in‐ and outpatient settings, to provide ...
Johanne Rozema +8 more
doaj +3 more sources
Dose Optimization and Targeting Strategies of Anti-Infective Agents [PDF]
Pharmaceutics, 2023 Most drugs are currently developed, approved and marketed based on their effect on the majority of the population [...]
Martin Šíma, Ondřej Slanař
doaj +2 more sources
Pharmacokinetics of anti-infective agents during CytoSorb hemoadsorption [PDF]
Scientific Reports, 2021 Cytokine hemoadsorption might be beneficial in patients with sepsis. However, its effect on anti-infective agents' disposition remains largely unknown.
Antoine G. Schneider +6 more
doaj +2 more sources
Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents [PDF]
Pharmaceuticals, 2021 Thienopyrimidines are widely represented in the literature, mainly due to their structural relationship with purine base such as adenine and guanine. This current review presents three isomers—thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and thieno[
Prisca Lagardère +3 more
doaj +2 more sources
The Role of Pathogens and Anti-Infective Agents in Parkinson’s Disease, from Etiology to Therapeutic Implications [PDF]
Journal of Parkinson’s Disease, 2022 Parkinson’s disease is a debilitating neurodegenerative disorder whose etiology is still unclear, hampering the development of effective treatments. There is an urgent need to identify the etiology and provide further effective treatments.
Si Shen +3 more
doaj +2 more sources
Infections, Anti-infective Agents, and Risk of Deliberate Self-harm and Suicide in a Young Cohort: A Nationwide Study [PDF]
Biological Psychiatry, 2019 BACKGROUND: Evidence links infections to mental disorders and suicidal behavior. However, knowledge is sparse regarding less severe infections, anti-infective treatment, and deliberate self-harm.
Hélène Gjervig Hansen +2 more
exaly +2 more sources
Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity
PharmaceuticalsDirect-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance ...
Thomas Shenk +2 more
doaj +2 more sources