Results 11 to 20 of about 162,736 (290)
Hybrid compounds as anti-infective agents [PDF]
Current Topics in Medicinal Chemistry, 2017 Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues ...
Sbaraglini, Maria Laura, Talevi, Alan
core +4 more sources
A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents [PDF]
Molecular Diversity, 2022 Tejas M Dhameliya
exaly +2 more sources
Editorial: Inspired by Nature: Towards Novel Anti-Infective Agents [PDF]
Frontiers in Pharmacology, 2022 Ricardo J. Ferreira +5 more
doaj +2 more sources
Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents. [PDF]
Clin Microbiol Rev, 2013 For the optimization of dosing regimens of anti-infective agents, it is imperative to have a good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever possible, drug efficacy needs to be related to unbound concentrations at the site
Gonzalez D, Schmidt S, Derendorf H.
europepmc +2 more sources
Mannose Derivatives as Anti-Infective Agents. [PDF]
Int J Mol SciMannose is a natural monosaccharide that plays a central role in host–pathogen interactions and has emerged as a versatile scaffold for designing anti-infective agents. This review summarizes recent advances in mannose-based glycoconjugates with antibacterial, antiviral, antifungal, and antiparasitic activity.
Ribić R.
europepmc +3 more sources
Pharmaceutics, 2021 Resistance to colistin, one of the antibiotics of last resort against multidrug-resistant Gram-negative bacteria, is increasingly reported. Notably, MCR plasmids discovered in 2015 have now been reported worldwide in humans.
Chantal Valcourt +5 more
doaj +1 more source
Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery
Pharmaceutics, 2020 To assess the difference in the fate of the antibiotic colistin (COLI) after its pulmonary delivery as a powder or a solution, we developed a COLI powder and evaluated the COLI pharmacokinetic properties in rats after pulmonary administration of the ...
Frédéric Tewes +7 more
doaj +1 more source
Emerging paradigms in anti-infective drug design. [PDF]
, 2014 The need for new drugs to treat microbial infections is pressing. The great progress made in the middle part of the twentieth Century was followed by a period of relative inactivity as the medical needs relating to infectious disease in the wealthier ...
Croft, Simon L +3 more
core +1 more source
Molecules, 2019 A series of novel tricyclic matrinic derivatives with 11-adamantyl substitution were designed, synthesized, and evaluated for their activities against Influenza A H3N2 virus, based on the privileged structure strategy.
Tianyu Niu +7 more
doaj +1 more source
, 2022 SIMPLE SUMMARY: Infections of bacterial, viral, or fungal origin pose a major threat to patients with acute leukemia. Empiric antibiotic and antifungal treatment is a commonly used approach in leukemia patients with febrile neutropenia.
Henes, Frank O. +19 more
core +1 more source