Results 11 to 20 of about 3,421,754 (284)
Hybrid Compounds as Anti-infective Agents [PDF]
Current Topics in Medicinal Chemistry, 2017 Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance ...
Sbaraglini, Maria Laura, Talevi, Alan
openaire +4 more sources
Editorial: Inspired by Nature: Towards Novel Anti-Infective Agents [PDF]
Frontiers in Pharmacology, 2022 Ricardo J. Ferreira +5 more
doaj +2 more sources
A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents [PDF]
Molecular Diversity, 2022 Tejas M Dhameliya
exaly +2 more sources
Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity
PharmaceuticalsDirect-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance ...
Thomas Shenk +2 more
doaj +2 more sources
Pharmaceutics, 2021 Resistance to colistin, one of the antibiotics of last resort against multidrug-resistant Gram-negative bacteria, is increasingly reported. Notably, MCR plasmids discovered in 2015 have now been reported worldwide in humans.
Chantal Valcourt +5 more
doaj +1 more source
Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery
Pharmaceutics, 2020 To assess the difference in the fate of the antibiotic colistin (COLI) after its pulmonary delivery as a powder or a solution, we developed a COLI powder and evaluated the COLI pharmacokinetic properties in rats after pulmonary administration of the ...
Frédéric Tewes +7 more
doaj +1 more source
Emerging paradigms in anti-infective drug design. [PDF]
, 2014 The need for new drugs to treat microbial infections is pressing. The great progress made in the middle part of the twentieth Century was followed by a period of relative inactivity as the medical needs relating to infectious disease in the wealthier ...
Croft, Simon L +3 more
core +1 more source
Molecules, 2019 A series of novel tricyclic matrinic derivatives with 11-adamantyl substitution were designed, synthesized, and evaluated for their activities against Influenza A H3N2 virus, based on the privileged structure strategy.
Tianyu Niu +7 more
doaj +1 more source
Anti-Infective Treatment and Resistance Is Rarely Problematic with Eye Infections
Antibiotics, 2022 The treatment of eye infections is very different than treating other body infections that require systemic anti-infectives. Endophthalmitis, keratitis, conjunctivitis, and other ocular infections are treated with direct injection and with topical drops ...
Regis P. Kowalski +3 more
doaj +1 more source
Infectious Disease Reports, 2017 There is now global recognition that antibiotic resistance is an emerging public health threat. Policy initiatives are underway to provide concrete suggestions for overcoming important obstacles in the fight against antibiotic resistance, like the ...
Ursula Theuretzbacher +2 more
doaj +1 more source