Results 11 to 20 of about 3,594,283 (182)

Hybrid Compounds as Anti-infective Agents [PDF]

Current Topics in Medicinal Chemistry, 2017
Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance ...
Sbaraglini, Maria Laura, Talevi, Alan
openaire   +4 more sources

Anti-Infective Treatment and Resistance Is Rarely Problematic with Eye Infections

Antibiotics, 2022
The treatment of eye infections is very different than treating other body infections that require systemic anti-infectives. Endophthalmitis, keratitis, conjunctivitis, and other ocular infections are treated with direct injection and with topical drops ...
Regis P. Kowalski, Shannon V. Nayyar, Eric G. Romanowski, Vishal Jhanji   +3 more
doaj   +2 more sources

Editorial: Inspired by Nature: Towards Novel Anti-Infective Agents [PDF]

Frontiers in Pharmacology, 2022
Ricardo J. Ferreira, Mariana A. Reis, Daniel Silva, Elisandra Scapin, Saikat Dewanjee, Marta P. Carrasco   +5 more
doaj   +2 more sources

Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity

Pharmaceuticals
Direct-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance ...
Thomas Shenk, John L. Kulp III, Lillian W. Chiang   +2 more
doaj   +2 more sources

Synthesis and Structure-Activity Relationships of Imidazopyridine/Pyrimidine- and Furopyridine-Based Anti-infective Agents against Trypanosomiases. [PDF]

ChemMedChem, 2021
Silva DG, Junker A, de Melo SMG, Fumagalli F, Gillespie JR, Molasky N, Buckner FS, Matheeussen A, Caljon G, Maes L, Emery FS.   +10 more
europepmc   +2 more sources

Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin

Pharmaceutics, 2021
Resistance to colistin, one of the antibiotics of last resort against multidrug-resistant Gram-negative bacteria, is increasingly reported. Notably, MCR plasmids discovered in 2015 have now been reported worldwide in humans.
Chantal Valcourt, Julien M. Buyck, Nicolas Grégoire, William Couet, Sandrine Marchand, Frédéric Tewes   +5 more
doaj   +1 more source

Mannose Derivatives as Anti-Infective Agents. [PDF]

Int J Mol Sci
Mannose is a natural monosaccharide that plays a central role in host–pathogen interactions and has emerged as a versatile scaffold for designing anti-infective agents. This review summarizes recent advances in mannose-based glycoconjugates with antibacterial, antiviral, antifungal, and antiparasitic activity.
Ribić R.
europepmc   +3 more sources

Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery

Pharmaceutics, 2020
To assess the difference in the fate of the antibiotic colistin (COLI) after its pulmonary delivery as a powder or a solution, we developed a COLI powder and evaluated the COLI pharmacokinetic properties in rats after pulmonary administration of the ...
Frédéric Tewes, Julien Brillault, Nicolas Gregoire, Jean-Christophe Olivier, Isabelle Lamarche, Christophe Adier, Anne-Marie Healy, Sandrine Marchand   +7 more
doaj   +1 more source

Minor groove binders as anti-infective agents

, 2013
Minor groove binders are small molecules that form strong complexes with the minor groove of DNA. There are several structural types of which distamycin and netropsin analogues, oligoamides built from heterocyclic and aromatic amino acids, and bis ...
Barrett, M.P., Gemmell, Curtis G, Gemmell, C.G., Suckling, Colin, Suckling, C.J.   +4 more
core   +4 more sources

Evolution and Biological Evaluation of Matrinic Derivatives with Amantadine Fragments As New Anti-Influenza Virus Agents

Molecules, 2019
A series of novel tricyclic matrinic derivatives with 11-adamantyl substitution were designed, synthesized, and evaluated for their activities against Influenza A H3N2 virus, based on the privileged structure strategy.
Tianyu Niu, Xiaoqiang Zhao, Jing Jiang, Haiyan Yan, Yinghong Li, Sheng Tang, Yuhuan Li, Danqing Song   +7 more
doaj   +1 more source