Results 11 to 20 of about 163,167 (287)

Hybrid Compounds as Anti-infective Agents [PDF]

Current Topics in Medicinal Chemistry, 2017
Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance ...
Sbaraglini, Maria Laura, Talevi, Alan
openaire   +5 more sources

Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity [PDF]

Pharmaceuticals
Direct-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance ...
Thomas Shenk, John L. Kulp III, Lillian W. Chiang   +2 more
doaj   +2 more sources

Editorial: Inspired by Nature: Towards Novel Anti-Infective Agents [PDF]

Frontiers in Pharmacology, 2022
Ricardo J. Ferreira, Mariana A. Reis, Daniel Silva, Elisandra Scapin, Saikat Dewanjee, Marta P. Carrasco   +5 more
doaj   +2 more sources

Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin

Pharmaceutics, 2021
Resistance to colistin, one of the antibiotics of last resort against multidrug-resistant Gram-negative bacteria, is increasingly reported. Notably, MCR plasmids discovered in 2015 have now been reported worldwide in humans.
Chantal Valcourt, Julien M. Buyck, Nicolas Grégoire, William Couet, Sandrine Marchand, Frédéric Tewes   +5 more
doaj   +1 more source

Diagnostic Utility of Bronchoalveolar Lavage in Patients with Acute Leukemia under Broad-Spectrum Anti-Infective Treatment [PDF]

, 2022
SIMPLE SUMMARY: Infections of bacterial, viral, or fungal origin pose a major threat to patients with acute leukemia. Empiric antibiotic and antifungal treatment is a commonly used approach in leukemia patients with febrile neutropenia.
Henes, Frank O., Carsten Bokemeyer, Hoffmann, Armin, Susanne Ghandili, Nick Benjamin Lindeman, Frank O. Henes, Modemann, Franziska, Armin Hoffmann, von Kroge, Philipp H., Holger Rohde, Rohde, Holger, Simon, Marcel, Marcel Simon, Franziska Modemann, Lindeman, Nick Benjamin, Walter Fiedler, Ghandili, Susanne, Bokemeyer, Carsten, Philipp H. von Kroge, Fiedler, Walter   +19 more
core   +1 more source

Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery

Pharmaceutics, 2020
To assess the difference in the fate of the antibiotic colistin (COLI) after its pulmonary delivery as a powder or a solution, we developed a COLI powder and evaluated the COLI pharmacokinetic properties in rats after pulmonary administration of the ...
Frédéric Tewes, Julien Brillault, Nicolas Gregoire, Jean-Christophe Olivier, Isabelle Lamarche, Christophe Adier, Anne-Marie Healy, Sandrine Marchand   +7 more
doaj   +1 more source

Emerging paradigms in anti-infective drug design. [PDF]

, 2014
The need for new drugs to treat microbial infections is pressing. The great progress made in the middle part of the twentieth Century was followed by a period of relative inactivity as the medical needs relating to infectious disease in the wealthier ...
Croft, Simon L, Barrett, Michael P., Barrett, Michael P, Croft, Simon L.   +3 more
core   +1 more source

Evolution and Biological Evaluation of Matrinic Derivatives with Amantadine Fragments As New Anti-Influenza Virus Agents

Molecules, 2019
A series of novel tricyclic matrinic derivatives with 11-adamantyl substitution were designed, synthesized, and evaluated for their activities against Influenza A H3N2 virus, based on the privileged structure strategy.
Tianyu Niu, Xiaoqiang Zhao, Jing Jiang, Haiyan Yan, Yinghong Li, Sheng Tang, Yuhuan Li, Danqing Song   +7 more
doaj   +1 more source

Organofluorinecontaining anti-infective agents [PDF]

, 2015
Fluorine atom is a suitable bioisostere in diverse organofluorine compounds acting as anti-infective ...
CATALANO, ALESSIA, CAROCCI, ALESSIA, CORBO, Filomena Faustina Rina, FRANCHINI, Carlo   +3 more
core   +1 more source

Seaweed‑associated heterotrophic bacteria: new paradigm of prospective anti‑infective and anticancer agents [PDF]

, 2021
Ever since the development of the first antibiotic compound with anticancer potential, researchers focused on isolation and characterization of prospective microbial natural products with potential anti-infective and anticancer activities.
Chakraborty, Kajal, Vinaya, K K
core   +1 more source