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Cryo-EM structures of African swine fever virus topoisomerase
mBio, 2023 Type II topoisomerases ubiquitously exist in cellular organisms, where they play an essential role in resolving the topological problems of DNA. The viral type II topoisomerase encoded by the African swine fever virus (ASFV) is critical for viral ...
Yan Zhao +5 more
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Viruses, 2022 Pathogenic E. coli cause urinary tract, soft tissue and central nervous system infections, sepsis, etc. Lytic bacteriophages can be used to combat such infections. We investigated six lytic E. coli bacteriophages isolated from wastewater.
Pavel Alexyuk +5 more
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Journal of the International Association of Providers of AIDS Care, 2023 Objective: The present study aimed to characterize the genotype distribution and clinical characteristics of HCV monoinfected and HCV/HIV coinfected patients in the Liangshan Prefecture, Sichuan Province, China.
Bianchuan Cao PhD +9 more
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Pathogens, 2021 Integrase strand transfer inhibitors (InSTIs) are recommended agents in first-line combination antiretroviral therapy (cART). We examined the evolution of drug resistance mutations throughout HIV-1 pol and the effects on InSTI susceptibility and viral ...
Supang A. Martin +3 more
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Frontiers in Molecular Biosciences, 2023 The emergence and re-emergence of viral diseases, which cause significant global mortality and morbidity, are the major concerns of this decade. Of these, current research is focused majorly on the etiological agent of the COVID-19 pandemic, SARS-CoV-2 ...
V. S. Lekshmi +5 more
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Antiviral drugs and antiviral drug resistance [PDF]
Current Opinion in Virology, 2011 Antiviral drugs and antiviral drug resistance can be matters of life and death for patients suffering from viral infections. They also can be valuable tools for understanding virus biology and biochemistry. Triumphs of antiviral therapy include acyclovir to treat genital herpes [1–4], triple combination chemotherapy for AIDS [5,6], and, quite recently,
Donald M, Coen, Richard J, Whitley
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Effects and mechanism of Aβ1−42 on EV-A71 replication
Virology Journal, 2022 Background β-Amyloid (Aβ) protein is a pivotal pathogenetic factor in Alzheimer’s disease (AD). However, increasing evidence suggests that the brain has to continuously produce excessive Aβ to efficaciously prevent pathogenic micro-organism infections ...
Ming Zhong +8 more
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Viruses, 2016 Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a mainstay of therapy for human immunodeficiency type 1 virus (HIV-1) infections. However, their effectiveness can be hampered by the emergence of resistant mutations.
Ming-Tain Lai +7 more
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Antivirals and antiviral strategies [PDF]
Nature Reviews Microbiology, 2004 In recent years, the demand for new antiviral strategies has increased markedly. There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral infections such as HIV and hepatitis B and C, and the emergence of new viruses such as the SARS coronavirus.
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Hyperbranched Polymers: Recent Advances in Photodynamic Therapy against Cancer
Pharmaceutics, 2023 Hyperbranched polymers are a class of three-dimensional dendritic polymers with highly branched architectures. Their unique structural features endow them with promising physical and chemical properties, such as abundant surface functional groups ...
Jie Chen, Yichuan Zhang
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