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Antiviral drugs and antiviral drug resistance [PDF]
Antiviral drugs and antiviral drug resistance can be matters of life and death for patients suffering from viral infections. They also can be valuable tools for understanding virus biology and biochemistry. Triumphs of antiviral therapy include acyclovir to treat genital herpes [1–4], triple combination chemotherapy for AIDS [5,6], and, quite recently,
Donald M, Coen, Richard J, Whitley
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After a discussion of the principles of antiviral chemotherapy, treatment and chemoprophylaxis of the following virus infections are reviewed in detail: the various manifestations of herpes simplex virus infections, varicella-zoster, cytomegalovirus infections, Epstein-Barr virus infections, laryngeal papillomas, and influenza A.
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Photosensitizing Antivirals [PDF]
Antiviral action of various photosensitizers is already summarized in several comprehensive reviews, and various mechanisms have been proposed for it. However, a critical consideration of the matter of the area is complicated, since the exact mechanisms are very difficult to explore and clarify, and most publications are of an empirical and ...
Kseniya A. Mariewskaya +5 more
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Antivirals and antiviral strategies [PDF]
In recent years, the demand for new antiviral strategies has increased markedly. There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral infections such as HIV and hepatitis B and C, and the emergence of new viruses such as the SARS coronavirus.
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Potent effective antiviral drugs recently have been licensed for several viral diseases, ushering in a new era in the treatment of viral diseases. Several unique features in the process of a viral infection have been identified as target points for inhibition. The unique steps and the interfering compounds are the subject of this review.
Reines, Eric D., Gross, Peter A.
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New antivirals are urgently needed to treat respiratory diseases caused by RNA viruses [...]
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Viruses are obligatory intracellular parasites, whose replication depends on pathways and functions of the host cell. Consequently, it is difficult to define virus-specific functions as suitable targets for anti-infective therapy. However, significant progress has been made in the past 50 years towards the development of effective and specific ...
Müller, B., Kräusslich, Hans-Georg
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Most viral respiratory tract infections are caused by classic respiratory viruses, including influenza, respiratory syncytial virus, human metapneumovirus, parainfluenza, rhinovirus, and adenovirus, whereas other viruses, such as herpes simplex, cytomegalovirus, and measles virus, can opportunistically affect the respiratory tract.
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Antiviral agents are drugs approved in the USA by the Food and Drug Administration (FDA) for the treatment or control of viral infections. Available antiviral agents mainly target stages in the viral life cycle. The target stages in the viral life cycle are; viral attachment to host cell, uncoating, synthesis of viral mRNA, translation of mRNA ...
Paintsil, E., Cheng, Yung-Chi
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Elion GB. History, mechanism of action, spectrum and selectivity of nucleoside analogs. In: Mills J, Corey L, eds: Antiviral chemotherapy: new directions for clinical applications and research. New York: Elsevier, 1986:118-37. Sasadeusz JJ, Sacks SL. Systemic antivirals in herpesvirus infections. Dermatol Clin 1993;11:171-85.
M, Busso, B, Berman
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