Results 41 to 50 of about 542,942 (306)

Novel activities of safe-in-human broad-spectrum antiviral agents [PDF]

, 2018
According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process.
Metelitsa, Natalja, Lysvand, Hilde,, Telling, Kaidi,, Anders Bergqvist, Kuivanen, Suvi,, Aittokallio, Tero,, Evander, Magnus,, Rebecca J. Cox, Valkonen, Miia,, Tenson, Tanel,, Evander, Magnus, Magnar Bjørås, Öhrmalm, Christina,, Laura Kakkola, Hukkanen, Veijo,, Lutsar, Irja, Svein Arne Nordbø, Zusinaite, Eva,, Strand, Mårten,, Bjørås, Magnar, Paavilainen, Henrik,, Bergqvist, Anders,, Olli Vapalahti, Aleksandr Ianevski, Strand, Mårten, Uga Dumpis, Öhrmalm, Christina, Anu Kantele, Bergqvist, Anders, Mona Teppor, Metelitsa, Natalja,, Laajala, Mira,, Irja Lutsar, Kallio-Kokko, Hannimari,, Mira Laajala, Merits, Andres, Astra Vitkauskiene, Ilkka Julkunen, Oksenych, Valentyn,, Tenson, Tanel, Julkunen, Ilkka,, Bjorås, Magnar,, Dumpis, Uga, Kallio-Kokko, Hannimari, Magnus Evander, Mårten Strand, Kåre Bondeson, Bondeson, Kåre,, Telling, Kaidi, Hilde Lysvand, Veijo Hukkanen, Vitkauskiene, Astra,, Bjoras, Magnar, Bondeson, Kåre, Kainov, Denis,, Varpu Marjomaki, Aittokallio, Tero, Vapalahti, Olli, Ianevski, Aleksandr,, Vitkauskiene, Astra, Eva Zusinaite, Kuivanen, Suvi, Suvi Kuivanen, Andres Merits, Oksenych, Valentyn, Letjuka, Pille, Christina Öhrmalm, Kantele, Anu, Vapalahti, Olli,, Miia Valkonen, Valkonen, Miia, Paavilainen, Henrik, Hukkanen, Veijo, Kantele, Anu,, Zusinaite, Eva, Julkunen, Ilkka, Tero Aittokallio, Kaidi Telling, Teppor, Mona,, Natalja Metelitsa, Valentyn Oksenych, Kainov, Denis, Marjomäki, Varpu, Marjomaki, Varpu,, Ianevski, Aleksandr, Tanel Tenson, Nordbo, Svein Arne,, Cox, Rebecca J.,, Nordbø, Svein Arne, Lysvand, Hilde, Denis Kainov, Laajala, Mira, Pille Letjuka, Letjuka, Pille,, Teppor, Mona, Kakkola, Laura, Nordbo, Svein Arne, Cox, Rebecca J., Henrik Paavilainen, Lutsar, Irja,, Hannimari Kallio-Kokko, Dumpis, Uga,, Merits, Andres,, Kakkola, Laura,   +103 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Antiviral screening of natural, anti-inflammatory compound library against African swine fever virus

Virology Journal
Background African swine fever virus (ASFV) is a major threat to pig production and the lack of effective vaccines underscores the need to develop robust antiviral countermeasures.
Joshua A. Jackman, Astghik Hakobyan, Rafayela Grigoryan, Roza Izmailyan, Charles C. Elrod, Hovakim Zakaryan   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Targeting SARS-CoV-2 main protease: a comprehensive approach using advanced virtual screening, molecular dynamics, and in vitro validation

Virology Journal
The COVID-19 pandemic, driven by the SARS-CoV-2 virus, necessitates the development of effective therapeutics. The main protease of the virus, Mpro, is a key target due to its crucial role in viral replication.
Smbat Gevorgyan, Hamlet Khachatryan, Anastasiya Shavina, Sajjad Gharaghani, Hovakim Zakaryan   +4 more
doaj   +1 more source

Antiviral Activity of Polyene Macrolides Against Newcastle Disease Virus: Computational and Experimental Insights

Molecules
The search for novel antiviral agents against Newcastle disease virus (NDV) remains a priority in industrial poultry farming due to the virus’s high contagiousness and associated economic losses, prompting evaluation of polyene macrolides as potential ...
Aidar Mukhametkaliyev, Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk, Nadezhda Sokolova, Yergali Moldakhanov, Kuralay Akanova, Aziza Temirbayeva, Assilbek Mussoyev, Krzysztof Śmietanka, Vladimir Berezin   +10 more
doaj   +1 more source

Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke

Frontiers in Cellular Neuroscience, 2022
N6-methyladenosine (m6A) is the most abundant post-transcription modification, widely occurring in eukaryotic mRNA and non-coding RNA. m6A modification is highly enriched in the mammalian brain and is associated with neurological diseases like Alzheimer ...
Fangfang Zhang, Yuanyuan Ran, Muhammad Tahir, Zihan Li, Jianan Wang, Xuechai Chen   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source