Results 51 to 60 of about 542,942 (306)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Dynamic alterations of oral fungal microbiota in Omicron infected patients

Scientific Reports
Oral fungal microbiota plays an important role in many diseases, however, the role of oral fungal microorganisms in the development of patients infected with Omicron has not been reported. A total of 963 tongue coating samples were prospectively included
Yarong Ma, Shanshuo Liu, Guizhen Zhang, Liwen Liu, Junyi Sun, Yawen Zou, Ying Sun, Lei Li, Benchen Rao, Haiyu Wang, Zujiang Yu, Zhigang Ren   +11 more
doaj   +1 more source

Phylodynamic and phylogeographic analysis of the complete genome of the West Nile virus lineage 2 (WNV-2) in the Mediterranean basin

BMC Ecology and Evolution, 2021
Background The West Nile virus is a highly contagious agent for a wide range of hosts. Its spread in the Mediterranean region raises several questions about its origin and the risk factors underlying the virus’s dispersal.
Haythem Srihi, Noureddine Chatti, Manel Ben Mhadheb, Jawhar Gharbi, Nabil Abid   +4 more
doaj   +1 more source

Antiviral therapy for human rabies

, 2015
Human rabies is virtually always fatal despite numerous attempts at aggressive therapy. Most survivors received one or more doses of rabies vaccine prior to the onset of the disease.
Jackson, Alan C., Appolinario, Camila M. [UNESP], Appolinario, Camila M.   +2 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Avaliação da citotoxicidade, da genotoxicidade e da potencial atividade antiviral da violaceína, produzida pela Chromobacterium violaceum [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.Os produtos naturais constituem uma fonte inesgotável de compostos com atividades farmacológicas promissoras, incluindo ...
Fröhner, Carla Regina Andrighetti
core  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Antiviral Res [PDF]

The 32nd International Conference on Antiviral Research (ICAR), sponsored by the International Society for Antiviral Research (ISAR), was held in Baltimore, Maryland, USA, on May 12-15, 2019.

core   +2 more sources

New antiviral approaches for human parainfluenza: Inhibiting the haemagglutinin-neuraminidase [PDF]

, 2019
Human parainfluenza viruses cause acute respiratory tract infections and disease predominantly in young children and immunocompromised individuals. Currently, there are no vaccines to prevent hPIV infections, nor licensed anti-hPIV drugs.
Thomson, Robin J, Benjamin Bailly, Ibrahim M. El-Deeb, Mark von Itzstein, von Itzstein, Mark, Dirr, Larissa, Robin J. Thomson, Guillon, Patrice, Larissa Dirr, Chibanga, Vimbaishe P, Patrice Guillon, Bailly, Benjamin, Vimbaishe P. Chibanga, El-Deeb, Ibrahim M   +13 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source