Results 51 to 60 of about 489,349 (309)

Antiviral Activity of Polyene Macrolides Against Newcastle Disease Virus: Computational and Experimental Insights

Molecules
The search for novel antiviral agents against Newcastle disease virus (NDV) remains a priority in industrial poultry farming due to the virus’s high contagiousness and associated economic losses, prompting evaluation of polyene macrolides as potential ...
Aidar Mukhametkaliyev, Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk, Nadezhda Sokolova, Yergali Moldakhanov, Kuralay Akanova, Aziza Temirbayeva, Assilbek Mussoyev, Krzysztof Śmietanka, Vladimir Berezin   +10 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Phylodynamic and phylogeographic analysis of the complete genome of the West Nile virus lineage 2 (WNV-2) in the Mediterranean basin

BMC Ecology and Evolution, 2021
Background The West Nile virus is a highly contagious agent for a wide range of hosts. Its spread in the Mediterranean region raises several questions about its origin and the risk factors underlying the virus’s dispersal.
Haythem Srihi, Noureddine Chatti, Manel Ben Mhadheb, Jawhar Gharbi, Nabil Abid   +4 more
doaj   +1 more source

Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke

Frontiers in Cellular Neuroscience, 2022
N6-methyladenosine (m6A) is the most abundant post-transcription modification, widely occurring in eukaryotic mRNA and non-coding RNA. m6A modification is highly enriched in the mammalian brain and is associated with neurological diseases like Alzheimer ...
Fangfang Zhang, Yuanyuan Ran, Muhammad Tahir, Zihan Li, Jianan Wang, Xuechai Chen   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Dynamic alterations of oral fungal microbiota in Omicron infected patients

Scientific Reports
Oral fungal microbiota plays an important role in many diseases, however, the role of oral fungal microorganisms in the development of patients infected with Omicron has not been reported. A total of 963 tongue coating samples were prospectively included
Yarong Ma, Shanshuo Liu, Guizhen Zhang, Liwen Liu, Junyi Sun, Yawen Zou, Ying Sun, Lei Li, Benchen Rao, Haiyu Wang, Zujiang Yu, Zhigang Ren   +11 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Avaliação da citotoxicidade, da genotoxicidade e da potencial atividade antiviral da violaceína, produzida pela Chromobacterium violaceum [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.Os produtos naturais constituem uma fonte inesgotável de compostos com atividades farmacológicas promissoras, incluindo ...
Fröhner, Carla Regina Andrighetti
core  

Novel activities of safe-in-human broad-spectrum antiviral agents [PDF]

, 2018
According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process.
Metelitsa, Natalja, Lysvand, Hilde,, Telling, Kaidi,, Anders Bergqvist, Kuivanen, Suvi,, Aittokallio, Tero,, Evander, Magnus,, Rebecca J. Cox, Valkonen, Miia,, Tenson, Tanel,, Evander, Magnus, Magnar Bjørås, Öhrmalm, Christina,, Laura Kakkola, Hukkanen, Veijo,, Lutsar, Irja, Svein Arne Nordbø, Zusinaite, Eva,, Strand, Mårten,, Bjørås, Magnar, Paavilainen, Henrik,, Bergqvist, Anders,, Olli Vapalahti, Aleksandr Ianevski, Strand, Mårten, Uga Dumpis, Öhrmalm, Christina, Anu Kantele, Bergqvist, Anders, Mona Teppor, Metelitsa, Natalja,, Laajala, Mira,, Irja Lutsar, Kallio-Kokko, Hannimari,, Mira Laajala, Merits, Andres, Astra Vitkauskiene, Ilkka Julkunen, Oksenych, Valentyn,, Tenson, Tanel, Julkunen, Ilkka,, Bjorås, Magnar,, Dumpis, Uga, Kallio-Kokko, Hannimari, Magnus Evander, Mårten Strand, Kåre Bondeson, Bondeson, Kåre,, Telling, Kaidi, Hilde Lysvand, Veijo Hukkanen, Vitkauskiene, Astra,, Bjoras, Magnar, Bondeson, Kåre, Kainov, Denis,, Varpu Marjomaki, Aittokallio, Tero, Vapalahti, Olli, Ianevski, Aleksandr,, Vitkauskiene, Astra, Eva Zusinaite, Kuivanen, Suvi, Suvi Kuivanen, Andres Merits, Oksenych, Valentyn, Letjuka, Pille, Christina Öhrmalm, Kantele, Anu, Vapalahti, Olli,, Miia Valkonen, Valkonen, Miia, Paavilainen, Henrik, Hukkanen, Veijo, Kantele, Anu,, Zusinaite, Eva, Julkunen, Ilkka, Tero Aittokallio, Kaidi Telling, Teppor, Mona,, Natalja Metelitsa, Valentyn Oksenych, Kainov, Denis, Marjomäki, Varpu, Marjomaki, Varpu,, Ianevski, Aleksandr, Tanel Tenson, Nordbo, Svein Arne,, Cox, Rebecca J.,, Nordbø, Svein Arne, Lysvand, Hilde, Denis Kainov, Laajala, Mira, Pille Letjuka, Letjuka, Pille,, Teppor, Mona, Kakkola, Laura, Nordbo, Svein Arne, Cox, Rebecca J., Henrik Paavilainen, Lutsar, Irja,, Hannimari Kallio-Kokko, Dumpis, Uga,, Merits, Andres,, Kakkola, Laura,   +103 more
core   +1 more source