Results 61 to 70 of about 489,349 (309)

Inhibition of African swine fever virus in liquid and feed by medium-chain fatty acids and glycerol monolaurate

Journal of Animal Science and Biotechnology, 2020
Background The ongoing African swine fever virus (ASFv) epidemic has had a major impact on pig production globally and biosecurity efforts to curb ASFv infectivity and transmission are a high priority.
Joshua A. Jackman, Astghik Hakobyan, Hovakim Zakaryan, Charles C. Elrod   +3 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

New antiviral approaches for human parainfluenza: Inhibiting the haemagglutinin-neuraminidase [PDF]

, 2019
Human parainfluenza viruses cause acute respiratory tract infections and disease predominantly in young children and immunocompromised individuals. Currently, there are no vaccines to prevent hPIV infections, nor licensed anti-hPIV drugs.
Thomson, Robin J, Benjamin Bailly, Ibrahim M. El-Deeb, Mark von Itzstein, von Itzstein, Mark, Dirr, Larissa, Robin J. Thomson, Guillon, Patrice, Larissa Dirr, Chibanga, Vimbaishe P, Patrice Guillon, Bailly, Benjamin, Vimbaishe P. Chibanga, El-Deeb, Ibrahim M   +13 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Antiviral treatment of Argentine hemorrhagic fever [PDF]

, 1994
Fil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Maiztegui, Julio I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Argentine hemorrhagic fever is a systemic ...
Enria, Delia, Maiztegui, Julio I.
core   +1 more source

Antiviral Res [PDF]

The 32nd International Conference on Antiviral Research (ICAR), sponsored by the International Society for Antiviral Research (ISAR), was held in Baltimore, Maryland, USA, on May 12-15, 2019.

core   +3 more sources

Alterations of the oral mycobiome in patients with CCA

BMC Oral Health
Background Emerging evidence links oral bacterial microbiota dysbiosis to cholangiocarcinoma (CCA). However, the oral mycobiome in CCA patients remains unexplored. This study aimed to characterize the oral mycobiome in CCA.
Tong Ren, Bohan Jia, Benchen Rao, Haiyu Wang, Shanshuo Liu, Mengzhao Yang, Zecheng Yang, Yarong Ma, Yanqiu Fu, Wenlong Di, Zujiang Yu, Zhigang Ren   +11 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Effect of antiviral treatment in older patients hospitalized with confirmed influenza [PDF]

Seasonal influenza causes significant morbidity and mortality in people aged ≥65 years. Antiviral treatment can reduce complications and disease severity.
Morales Suárez-Varela, María M., Soldevila, Nuria   +1 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source