Results 61 to 70 of about 526,776 (304)

Isolamento e indentificação de subsatâncias ativas de araucaria angustifolia (Bert.) O. Kuntze com potencial atividade antiviral [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.Araucaria angustifolia é uma árvore de grande porte que ocorre na floresta ombrófila mista, um ecossistema único dentro do
Almeida, Maria Tereza Rojo de
core  

Alterations of the oral mycobiome in patients with CCA

BMC Oral Health
Background Emerging evidence links oral bacterial microbiota dysbiosis to cholangiocarcinoma (CCA). However, the oral mycobiome in CCA patients remains unexplored. This study aimed to characterize the oral mycobiome in CCA.
Tong Ren, Bohan Jia, Benchen Rao, Haiyu Wang, Shanshuo Liu, Mengzhao Yang, Zecheng Yang, Yarong Ma, Yanqiu Fu, Wenlong Di, Zujiang Yu, Zhigang Ren   +11 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Targeting β2-Adrenergic Receptor Stability With Lycorine Reveals a Host-Directed Pathway for Antiviral Defense Against Poxviruses. [PDF]

Adv Sci (Weinh)
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Zhang X, Xu S, Zhang Z, Wan C, Wang X, Wang P, Yang H, Huang T, Yuan Y, Atique F, Yang R, He Y, Liu Z.   +12 more
europepmc   +2 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Antiviral Res [PDF]

The 32nd International Conference on Antiviral Research (ICAR), sponsored by the International Society for Antiviral Research (ISAR), was held in Baltimore, Maryland, USA, on May 12-15, 2019.

core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Novel activities of safe-in-human broad-spectrum antiviral agents [PDF]

, 2018
According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process.
Metelitsa, Natalja, Lysvand, Hilde,, Telling, Kaidi,, Anders Bergqvist, Kuivanen, Suvi,, Aittokallio, Tero,, Evander, Magnus,, Rebecca J. Cox, Valkonen, Miia,, Tenson, Tanel,, Evander, Magnus, Magnar Bjørås, Öhrmalm, Christina,, Laura Kakkola, Hukkanen, Veijo,, Lutsar, Irja, Svein Arne Nordbø, Zusinaite, Eva,, Strand, Mårten,, Bjørås, Magnar, Paavilainen, Henrik,, Bergqvist, Anders,, Olli Vapalahti, Aleksandr Ianevski, Strand, Mårten, Uga Dumpis, Öhrmalm, Christina, Anu Kantele, Bergqvist, Anders, Mona Teppor, Metelitsa, Natalja,, Laajala, Mira,, Irja Lutsar, Kallio-Kokko, Hannimari,, Mira Laajala, Merits, Andres, Astra Vitkauskiene, Ilkka Julkunen, Oksenych, Valentyn,, Tenson, Tanel, Julkunen, Ilkka,, Bjorås, Magnar,, Dumpis, Uga, Kallio-Kokko, Hannimari, Magnus Evander, Mårten Strand, Kåre Bondeson, Bondeson, Kåre,, Telling, Kaidi, Hilde Lysvand, Veijo Hukkanen, Vitkauskiene, Astra,, Bjoras, Magnar, Bondeson, Kåre, Kainov, Denis,, Varpu Marjomaki, Aittokallio, Tero, Vapalahti, Olli, Ianevski, Aleksandr,, Vitkauskiene, Astra, Eva Zusinaite, Kuivanen, Suvi, Suvi Kuivanen, Andres Merits, Oksenych, Valentyn, Letjuka, Pille, Christina Öhrmalm, Kantele, Anu, Vapalahti, Olli,, Miia Valkonen, Valkonen, Miia, Paavilainen, Henrik, Hukkanen, Veijo, Kantele, Anu,, Zusinaite, Eva, Julkunen, Ilkka, Tero Aittokallio, Kaidi Telling, Teppor, Mona,, Natalja Metelitsa, Valentyn Oksenych, Kainov, Denis, Marjomäki, Varpu, Marjomaki, Varpu,, Ianevski, Aleksandr, Tanel Tenson, Nordbo, Svein Arne,, Cox, Rebecca J.,, Nordbø, Svein Arne, Lysvand, Hilde, Denis Kainov, Laajala, Mira, Pille Letjuka, Letjuka, Pille,, Teppor, Mona, Kakkola, Laura, Nordbo, Svein Arne, Cox, Rebecca J., Henrik Paavilainen, Lutsar, Irja,, Hannimari Kallio-Kokko, Dumpis, Uga,, Merits, Andres,, Kakkola, Laura,   +103 more
core   +1 more source

Antivirals in dermatology

Journal of the American Academy of Dermatology, 1995
Elion GB. History, mechanism of action, spectrum and selectivity of nucleoside analogs. In: Mills J, Corey L, eds: Antiviral chemotherapy: new directions for clinical applications and research. New York: Elsevier, 1986:118-37. Sasadeusz JJ, Sacks SL. Systemic antivirals in herpesvirus infections. Dermatol Clin 1993;11:171-85.
M, Busso, B, Berman
openaire   +2 more sources