Results 81 to 90 of about 526,776 (304)

HIV-1 Nef activates proviral DNA transcription by recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive function

Journal of Virology
HIV-1 accessory protein Nef is a multifunctional pathogenic factor that mediates immune evasion, enhances virion infectivity, antagonizes host restrictive factors, and promotes viral dissemination.
Tian-Jiao Fan, Chengzuo Xie, Lisha Li, Xia Jin, Jie Cui, Jian-Hua Wang   +5 more
doaj   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

Activation and modulation of antiviral and apoptotic genes in pigs infected with classical swine fever viruses of high, moderate or low virulence [PDF]

, 2009
The immune response to CSFV and the strategies of this virus to evade and suppress the pigs’ immune system are still poorly understood. Therefore, we investigated the transcriptional response in the tonsils, median retropharyngeal lymph node (MRLN), and ...
Hulst, M.M., Loeffen, W.L.A., Wit, A.A.C., de, A. A. C. de Wit, Mastebroek, B., S. V. M. Durand, W. L. A. Loeffen, Durand, S.V.M., L. Mastebroek, M. M. Hulst, de Wit, A.A.C.   +10 more
core   +1 more source

Alterations of the oral microbiome in patients reinfected with SARS‐CoV‐2 omicron variants

View
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection induces perturbations in the human oral microbiome. However, alterations of the oral microbiome in patients reinfected with SARS‐CoV‐2 omicron variant (ORs) remain uncharacterized. We
Benchen Rao, Yongjian Zhou, Tong Ren, Hongxia Liang, Lei Li, Yakun Xu, Haiyu Wang, Xiaoping Wang, Xiaoli Ni, Xiaoning Wang, Hanmeng Liu, Xiaoli Jin, Qiaoxia Chen, Xuemei Wang, Yawen Zou, Ying Sun, Zhigang Ren, Zujiang Yu   +17 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Honey as an antiviral agent against respiratory syncytial virus [PDF]

, 2011
Respiratory syncytial virus is the most frequent cause of hospitalization for viral respiratory infections in infants and young children worldwide. It also severely affects immunocompromised adults and the elderly, however, despite decades of efforts ...
Zareie, Parvaneh Palma
core  

The antiviral effect of mollusk mucus on measles virus

, 2016
Measles is a viral disease highly contagious spread by respiratory transmission. Although infection can be controlled by vaccination, numerous cases of measles have been registered in many areas of the world, highlighting the need for additional ...
Namiyama, Gislene, Villar, Karina de Senna, de Toledo-Piza, Ana Rita, Negri, Giuseppina [UNIFESP], Tonelotto, Mariana, Figueiredo, Cristina Adelaide, de Oliveira, Maria Isabel, Rofatto, Henrique Krambeck, Mendonca, Ronaldo Zucatelli   +8 more
core   +1 more source

A robust cell-based infection model for Rhinovirus C research and antiviral drug discovery

npj Viruses
Rhinoviruses (RV) comprise three species, RV-A, RV-B, and RV-C, with approximately 170 types. RV-C is associated with severe respiratory illness, particularly in children and individuals with asthma or chronic obstructive pulmonary disease, underscoring ...
Heyrhyoung Lyoo, Yeranddy A. Alpizar, Céline Sablon, Toon Röpke, Jasmine Paulissen, Madina Rasulova, Nathalie Thys, Chang-Soo Yun, Nam-Chul Cho, Kai Dallmeier, Pieter Leyssen, Soo-Bong Han, Johan Neyts, Hendrik Jan Thibaut   +13 more
doaj   +1 more source

Bacteroides thetaiotaomicron ameliorates mouse hepatic steatosis through regulating gut microbial composition, gut-liver folate and unsaturated fatty acids metabolism

Gut Microbes
Gut microbiota plays an essential role in the progression of nonalcoholic fatty liver disease (NAFLD), making the gut-liver axis a potential therapeutic strategy.
Hu Li, Xue-Kai Wang, Mei Tang, Lei Lei, Jian-Rui Li, Han Sun, Jing Jiang, Biao Dong, Hong-Ying Li, Jian-Dong Jiang, Zong-Gen Peng   +10 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source