Results 1 to 10 of about 2,726 (170)

Biochemical Characterization of an Arabinoside Monophosphate Specific 5′-Nucleotidase-like Enzyme from Streptomyces antibioticus [PDF]

Biomolecules
To investigate the function of the gene penF in the pentostatin and vidarabine (Ara-A) biosynthetic gene cluster in Streptomyces antibioticus NRRL 3238, PenF was recombinantly expressed and characterized.
Yuxue Liu, Xiaobei Liu, Xiaojing Zhang, Xiaoting Tang, Weiwei Su, Zhenyu Wang, Hailei Wang   +6 more
doaj   +3 more sources

Biosynthesis of Arabinoside from Sucrose and Nucleobase via a Novel Multi-Enzymatic Cascade [PDF]

Biomolecules
Arabinoside and derived nucleoside analogs, a family of nucleoside analogs, exhibit diverse typically biological activities and are widely used as antibacterial, antiviral, anti-inflammatory, antitumor, and other drugs in clinical and preclinical trials.
Yuxue Liu, Erchu Yang, Xiaojing Zhang, Xiaobei Liu, Xiaoting Tang, Zhenyu Wang, Hailei Wang   +6 more
doaj   +2 more sources

Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes

Marine Drugs, 2020
The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial ...
Marilia Barreca, Virginia Spanò, Alessandra Montalbano, Mercedes Cueto, Ana R. Díaz Marrero, Irem Deniz, Ayşegül Erdoğan, Lada Lukić Bilela, Corentin Moulin, Elisabeth Taffin-de-Givenchy, Filippo Spriano, Giuseppe Perale, Mohamed Mehiri, Ana Rotter, Olivier P. Thomas, Paola Barraja, Susana P. Gaudêncio, Francesco Bertoni   +17 more
doaj   +1 more source

Vidarabine encephalopathy. [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1984
Vidarabine (adenine arabinoside, ara-a) has been found to be useful in the treatment of various viral infections. Its adverse neurological effects include tremor and encephalopathy. Two cases of vidarabine encephalopathy are reported and the five other cases in the literature are reviewed.
P A, Cullis, R, Cushing
openaire   +2 more sources

VP37 Protein Inhibitors for Mpox Treatment: Highlights on Recent Advances, Patent Literature, and Future Directions

Biomedicines, 2023
Monkeypox disease (Mpox) has threatened humankind worldwide since mid-2022. The Mpox virus (MpoxV) is an example of Orthopoxviruses (OPVs), which share similar genomic structures. A few treatments and vaccines are available for Mpox.
Shuaibu A. Hudu, Ahmed S. Alshrari, Aiman Al Qtaitat, Mohd Imran   +3 more
doaj   +1 more source

Standardized Polyalthia longifolia leaf extract induces the apoptotic HeLa cells death via microRNA regulation: identification, validation, and therapeutic potential

Frontiers in Pharmacology, 2023
Polyalthia longifolia var. angustifolia Thw. (Annonaceae), is a famous traditional medicinal plant in Asia. Ample data specifies that the medicinal plant P.
Soundararajan Vijayarathna, Chern Ein Oon, Majid Al-Zahrani, Muyassar H. Abualreesh, Yeng Chen, Jagat R. Kanwar, Sumaira Sahreen, Shakira Ghazanfar, Mohd Adnan, Sreenivasan Sasidharan   +9 more
doaj   +1 more source

Determination of Phenolics and Flavonoids of Some Useful Medicinal Plants and Bioassay-Guided Fractionation Substances of Sclerocarya birrea (A. Rich) Hochst Stem (Bark) Extract and Their Efficacy Against Salmonella typhi

Frontiers in Chemistry, 2021
Gallic acid and catechin are the most abundant phenolic and flavonoid contents found in all plant extracts. The contents and the bioassay-guided fractionating substances of the Sclerocarya birrea (A.
Muhammad Salihu Abdallah, Muhammad Salihu Abdallah, Muskhazli Mustafa, Meenakshii A/P. Nallappan, Sangho Choi, Jin-Hyub Paik, Go Rusea   +6 more
doaj   +1 more source

Recent Advances in Molecular Docking for the Research and Discovery of Potential Marine Drugs

Marine Drugs, 2020
Marine drugs have long been used and exhibit unique advantages in clinical practices. Among the marine drugs that have been approved by the Food and Drug Administration (FDA), the protein–ligand interactions, such as cytarabine–DNA polymerase, vidarabine–
Guilin Chen, Armel Jackson Seukep, Mingquan Guo   +2 more
doaj   +1 more source

Modern approaches to the treatment of herpetic infection in children

Aktualʹnaâ Infektologiâ, 2019
It is currently known 8 pathogenic herpesviruses: two types of herpes simplex virus (HSV-1, HSV-2), varicella zoster virus, Epstein-Barr virus, cytomegalovirus, HHV-6, HHV-7, and HHV-8.
S.O. Kramarov, V.V. Yevtushenko
doaj   +1 more source

Biologically active substances from water invertebrates: a review

Veterinární Medicína, 2012
Some species of invertebrates especially bryozoans (Bryozoa syn. Ectoprocta) and marine sponges (Porifera) are very important sources of pharmacologically exploitable compounds.
J. Sinko, J. Rajchard, Z. Balounova, L. Fikotova   +3 more
doaj   +1 more source