Results 21 to 30 of about 2,726 (170)

Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight

Journal of Pharmacological Sciences, 2012
We previously demonstrated that type 5 adenylyl cyclase (AC5) functions in autonomic regulation in the heart. Based on that work, we hypothesized that pharmacological modulation of AC5 activity could regulate the autonomic control of the heart rate under
Yunzhe Bai, Takashi Tsunematsu, Qibin Jiao, Yoshiki Ohnuki, Yasumasa Mototani, Kouichi Shiozawa, Meihua Jin, Wenqian Cai, Hui-Ling Jin, Takayuki Fujita, Yasuhiro Ichikawa, Kenji Suita, Reiko Kurotani, Utako Yokoyama, Motohiko Sato, Kousaku Iwatsubo, Yoshihiro Ishikawa, Satoshi Okumura   +17 more
doaj   +2 more sources

Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach [PDF]

Open Veterinary Journal
Background: Lumpy skin disease (LSD) is a transboundary virus disease that mostly affects cattle. It has recently reported all over the world, which highlights the need for efficient control methods. LSD poses serious economic dangers worldwide. Aim:
S. Vamshi Krishna, Aniket Sarkar, Suchandan Banerjee, Anindya Sundar Panja   +3 more
doaj   +2 more sources

Inosine, AMP, and Vidarabine: Network Pharmacology and LC-MS Reveal Key Bioactive Compounds in <i>Periplaneta americana</i> for Ulcerative Colitis Management. [PDF]

Int J Mol Sci
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unmet therapeutic needs. This study investigates the therapeutic potential of Periplaneta americana L.
Li Y, Shi ZM, He Y, Xi ZW, Che YH, Zhao HR, Zhang CG, Liu H, Hu KF.   +8 more
europepmc   +2 more sources

Successful treatment of acyclovir‐resistant herpes simplex virus infection with amenamevir in a patient who received umbilical cord blood transplantation for T‐cell prolymphocytic leukemia

eJHaem
A 34‐year‐old woman received umbilical cord blood transplantation for refractory T‐cell prolymphocytic leukemia after salvage therapy with alemtuzumab.
Yuma Kawamura, Nako Uchibori, Tomoya Arakawa, Tomoki Fujii, Shuto Negishi, Shiori Morikawa, Nobuaki Fukushima, Akio Kohno, Souichi Yamada, Yoshiko Fukui, Shuetsu Fukushi, Kazutaka Ozeki   +11 more
doaj   +2 more sources

Chemical composition, metabolomics, and functional potential of Pholiota nameko pre-cooking liquid [PDF]

Scientific Reports
The liquid generated during the pre-cooking process of Pholiota nameko is frequently considered waste, and its large-scale disposal may pose environmental risks.
Yongbin Meng, Jing Xue, Lirong Zhang, Xiaoqi Ouyang, Sitian Zhou, Lei Feng, Chengyu Zheng, Guoliang Chen, Yuanyuan Zhang, Xiaolong He   +9 more
doaj   +2 more sources

A Screening Study Identified Decitabine as an Inhibitor of Equid Herpesvirus 4 That Enhances the Innate Antiviral Response [PDF]

Viruses
Equid herpesvirus 4 (EHV-4) is a common respiratory pathogen in horses. It sporadically induces abortion or neonatal death. Although its contribution in neurological disorders is not clearly demonstrated, there is a strong suspicion of its involvement ...
Camille Normand, Côme J. Thieulent, Christine Fortier, Gabrielle Sutton, Catherine Senamaud-Beaufort, Laurent Jourdren, Corinne Blugeon, Pierre-Olivier Vidalain, Stéphane Pronost, Erika S. Hue   +9 more
doaj   +2 more sources

Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2

Viruses, 2021
Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is ...
Lauren A. Sadowski, Rista Upadhyay, Zachary W. Greeley, Barry J. Margulies   +3 more
doaj   +1 more source

Formulation and Evaluation Oral Dispersible Tablets of Vidarabine

, 2023
<p><strong>Abstract</strong></p><p>In the present work, taste masking of Vidarabine was carried out by using HP-β-CD inclusion complex.
Akula Priyanka
core   +2 more sources

Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism. [PDF]

PLoS ONE, 2012
To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase;
Louise Egeblad, Martin Welin, Susanne Flodin, Susanne Gräslund, Liya Wang, Jan Balzarini, Staffan Eriksson, Pär Nordlund   +7 more
doaj   +1 more source

Similarly potent inhibition of adenylyl cyclase by P-site inhibitors in hearts from wild type and AC5 knockout mice. [PDF]

PLoS ONE, 2013
Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO) exerted cardioprotective effects in heart failure.
Joerg H Braeunig, Frank Schweda, Pyung-Lim Han, Roland Seifert   +3 more
doaj   +1 more source