Results 21 to 30 of about 3,681 (204)

Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption [PDF]

, 2013
Disruption of adenylyl cyclase type 5 (AC5) knockout (KO) is a novel model for longevity. Because malignancy is a major cause of death and reduced lifespan in mice, the goal of this investigation was to examine the role of AC5KO in protecting against ...
Baljinnyam, Erdene, Bishop, Sanford P., Carlini, María José, Chen, Wen, De Lorenzo, Mariana S., La Perle, Krista, Puricelli, Lydia Ines, Rabson, Arnold B., Vatner, Dorothy E., Vatner, Stephen F., Wagner, Thomas E.   +10 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight

Journal of Pharmacological Sciences, 2012
We previously demonstrated that type 5 adenylyl cyclase (AC5) functions in autonomic regulation in the heart. Based on that work, we hypothesized that pharmacological modulation of AC5 activity could regulate the autonomic control of the heart rate under
Yunzhe Bai, Takashi Tsunematsu, Qibin Jiao, Yoshiki Ohnuki, Yasumasa Mototani, Kouichi Shiozawa, Meihua Jin, Wenqian Cai, Hui-Ling Jin, Takayuki Fujita, Yasuhiro Ichikawa, Kenji Suita, Reiko Kurotani, Utako Yokoyama, Motohiko Sato, Kousaku Iwatsubo, Yoshihiro Ishikawa, Satoshi Okumura   +17 more
doaj   +1 more source

Non‐canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure

The FEBS Journal, Volume 290, Issue 20, Page 4899-4920, October 2023., 2023
The expanding fields of mRNA therapeutics and epitranscriptomics require methods to produce RNA containing unnatural nucleosides. We have devised an adaptable system for the enzymatic triphosphorylation of a wide variety of non‐canonical nucleosides. This allows in vitro transcription of RNA containing modified nucleoside analogues and subsequent mRNA ...
Patricia Benčić, Michael Keppler, Marco Kuge, Danye Qiu, Lena M. Schütte, Markus Häner, Katharina Strack, Henning J. Jessen, Jennifer N. Andexer, Christoph Loenarz   +9 more
wiley   +1 more source

In Silico Exploration of Potential Natural Inhibitors against SARS-Cov-2 nsp10

Molecules, 2021
In continuation of our previous effort, different in silico selection methods were applied to 310 naturally isolated metabolites that exhibited antiviral potentialities before.
Ibrahim H. Eissa, Mohamed M. Khalifa, Eslam B. Elkaeed, Elsayed E. Hafez, Aisha A. Alsfouk, Ahmed M. Metwaly   +5 more
doaj   +1 more source

Neonatal herpes simplex virus infection: From the maternal infection to the child outcome

Journal of Medical Virology, Volume 95, Issue 8, August 2023., 2023
Abstract This review examines the recent literature on the management of herpes simplex virus (HSV) infections in neonates. We summarized the three clinical categories of maternal HSV infection during pregnancy (primary first episode, nonprimary first episode, or recurrent episode) and the mechanisms of fetal damage.
Domenico Umberto De Rose, Sarah Bompard, Chiara Maddaloni, Iliana Bersani, Ludovica Martini, Alessandra Santisi, Daniela Longo, Maria Paola Ronchetti, Andrea Dotta, Cinzia Auriti   +9 more
wiley   +1 more source

Treatment of eczema herpeticum with acyclovir [PDF]

, 1983
Contains fulltext : 4421.pdf (publisher's version ) (Open ...
Enschedé, F.A.J., Meer, J.W.M. van der, Swart, R.N.J., Vermeer, B.J., Versteeg, J.   +4 more
core   +2 more sources

Safety and efficacy of elapegademase in patients with adenosine deaminase deficiency: A multicenter, open‐label, single‐arm, phase 3, and postmarketing clinical study

Immunity, Inflammation and Disease, Volume 11, Issue 7, July 2023., 2023
Time course changes in the trough dAXP concentrations of erythrocytes and whole blood. Abstract Introduction Adenosine deaminase (ADA) deficiency is an ultrarare inherited purine metabolism disorder characterized by severe combined immunodeficiency. Elapegademase‐lvlr is a new pegylated recombinant bovine ADA used in enzyme‐replacement therapy (ERT ...
Masafumi Onodera, Toru Uchiyama, Tadashi Ariga, Masafumi Yamada, Takako Miyamura, Hironori Arizono, Tomohiro Morio   +6 more
wiley   +1 more source

Human Deoxycytidine Kinase Is a Valuable Biocatalyst for the Synthesis of Nucleotide Analogues [PDF]

, 2019
Natural ribonucleoside-5’-monophosphates are building blocks for nucleic acids which are used for a number of purposes, including food additives. Their analogues, additionally, are used in pharmaceutical applications.
Hellendahl, Katja F., Kamel, Sarah, Neubauer, Peter, Wagner, Anke, Wetterwald, Albane   +4 more
core   +1 more source

Vidarabine encephalopathy. [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1984
Vidarabine (adenine arabinoside, ara-a) has been found to be useful in the treatment of various viral infections. Its adverse neurological effects include tremor and encephalopathy. Two cases of vidarabine encephalopathy are reported and the five other cases in the literature are reviewed.
P A, Cullis, R, Cushing
openaire   +2 more sources