Results 1 to 10 of about 6,386 (141)

CMV Preventive and Treatment Studies in Children Undergoing Haematopoietic Stem Cell Transplant: A Systematic Review. [PDF]

Rev Med Virol
ABSTRACT Cytomegalovirus (CMV) is one of the most important infectious causes of morbidity and mortality in children undergoing haematopoietic stem cell transplant (HSCT). However, the evidence for preventing and treating CMV disease in children in this context remains limited. We sought to review the current available evidence regarding the prevention
Fusani L, Fusco E, Fonseca M, Breuer J, Rao K, Galli L, Bamford A, Kadambari S.   +7 more
europepmc   +2 more sources

The Troll Is Weakened but Not yet Defeated: An Update on Cytomegalovirus Management in Transplantation From the International CMV Symposium 2025. [PDF]

Transpl Infect Dis
This review synthesizes discussions from the 2025 International CMV Symposium on translating three recently updated international guidelines into clinical practice across solid organ and hematopoietic stem cell transplantation, highlighting advances in risk‐stratified prevention, emerging therapies, immune monitoring, and persistent implementation ...
Kotton CN, Sester M, Torre-Cisneros J, International CMV Symposium Faculty.   +3 more
europepmc   +2 more sources

Acyclovir-Resistant Herpes Simplex Virus in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant: A Case Series. [PDF]

Transpl Infect Dis
This retrospective case series of acyclovir‐resistant HSV infection in pediatric patients undergoing allogeneic HSCT discusses the clinical course, associated complications, and treatment, including side effects. We propose the first algorithm for investigating and managing acyclovir‐resistant HSV infections in pediatric HSCT recipients, highlighting ...
Nunn J, Ahmed A, Senthil S, Mirci-Danicar O, Bonney D, Horgan C, Mustafa O, Wynn R, Guiver M, Nataraj R.   +9 more
europepmc   +2 more sources

Characteristics of Acyclovir-Resistant Herpes Simplex Virus Infection in Hematological Patients. [PDF]

J Oral Pathol Med
ABSTRACT Objective Acyclovir‐resistant herpes simplex virus infections pose a significant challenge in immunosuppressed patients. This study aimed to characterize the clinical features, treatment outcomes, and mortality associated with acyclovir‐resistant herpes simplex virus infection. Materials and Methods A retrospective analysis was conducted on 18
Shehadeh R, Bar Ilan M, Dovrat S, Yerushalmi R, Tepperberg Oikawa M, Piperi E, Nikitakis NG, Yarom N.   +7 more
europepmc   +2 more sources

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review. [PDF]

Clin Pharmacol Ther
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Alatawi W, Wallace JL, Rungkitwattanakul D, Stottlemyer BA, Tran TL, Reida MM, Kane-Gill SL.   +6 more
europepmc   +2 more sources

Foscarnet-Type Inorganic-Organic Hybrid Nanoparticles for Effective Antiviral Therapy

, 2022
[ZrO]2+[(FCN)0.4(OH)0.8]2– and Gd3+[FCN]3– inorganic-organic hybrid nanoparticles (IOH-NPs) are novel saline antiviral nanocarriers with foscarnet (FCN) as a drug anion.
Mikhail Khorenko, Mikhail Khorenko (12310322), Luka Cicin-Sain, Ulfert Rand, Ulfert Rand (525417), Luka Cicin-Sain (3385982), Claus Feldmann (1583260), Claus Feldmann   +7 more
core   +1 more source

Foscarnet Decreases Human Immunodeficiency Virus RNA [PDF]

, 1995
Foscarnet inhibits human immunodeficiency virus (HIV) replication in vitro and decreases p24 antigenemia in patients with cytomegalovirus (CMV) retinitis.
H. Furrer, Kaiser, Laurent, M. Olmari, Yerly, Sabine, J. Von Overbeck, Furrer, Hansjakob, B. Hirschel, Hirschel, Bernard, Olmari, Maya, Von Overbeck, Jan, L. Perrin, L. Kaiser, Perrin, Luc, S. Yerly   +13 more
core   +1 more source

A randomized, controlled trial comparing ganciclovir to ganciclovir plus foscarnet (each at half dose) for preemptive therapy of cytomegalovirus infection in transplant recipients

, 2004
Forty-eight patients who provided 2 consecutive blood samples that tested positive for cytomegalovirus DNA by polymerase chain reaction (PCR) were randomized to receive either full-dose ganciclovir ( 5 mg/kg intravenously [iv] twice daily) or half-dose ...
Potter, M, Okwuadi, S., Amooty, G., Nebbia, G, Mattes, F. M., Griffiths, PD, Burroughs, A. K., Burroughs, AK, Grace, SC, Hainsworth, EG, Griffiths, P. D., Sweny, P, Grace, S. C., Amooty, G, Emery, V. C., Walker, AFH, Prentice, G., Sweny, P., Hainsworth, E. G., Geretti, AM, Nebbia, G., Sabin, C, Emery, VC, Sabin, C., Geretti, A. M., Potter, M., Brown, V. S., Okwuadi, S, Brown, VS, Hassan-Walker, A. F., Mattes, FM, Prentice, G   +31 more
core   +1 more source

Effect of foscarnet induction treatment on quantitation of human cytomegalovirus (HCMV) DNA in blood leukocytes and aqueous humor of AIDS patients with HCMV retinitis

, 1994
The aim of this study was to investigate peripheral blood polymorphonuclear leukocytes and, whenever possible, aqueous humor from 65 AIDS patients with ophthalmoscopically diagnosed human cytomegalovirus (HCMV) retinitis to determine (i) whether patients
ZELLA D., BALDANTI F., ZIPETO, Donato, GERNA G., SARASINI A., PERCIVALLE E., REVELLO M. G., AND THE ITALIAN FOSCARNET STUDY GROUP, FURIONE M.   +8 more
core   +1 more source

Foscarnet Versus Ganciclovir for Severe Congenital Cytomegalovirus Infection: Short- and Long-Term Follow-Up. [PDF]

Viruses
Background: Cytomegalovirus (CMV) infection is the most common and serious congenital infection, with universal screening in pregnancy, standardized therapy, and a vaccine still lacking.
Nigro G, Buzzi M, Catenaro M, Coclite E, Muselli M.   +4 more
europepmc   +2 more sources