Results 41 to 50 of about 1,295 (151)

A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet [PDF]

, 2006
International audienceFoscarnet is currently licensed for the treatment of human cytomegalovirus (HCMV) infection. Mutations proven to confer resistance to foscarnet have mostly been mapped to regions II, III and VI of the HCMV UL54-encoded DNA ...
Mazeron, Marie-Christine, Petit, Françoise, Champier, Gaël, Ducancelle, Alexandra, Le Pors, Marie-José Sanson, Alain, Sophie   +5 more
core   +2 more sources

Human Herpesvirus 8 Causes a Wide Spectrum of Disease in Liver Transplant Recipients and May be Donor Derived: Case Series and Systematic Review of an Emerging Challenge

Transplant Infectious Disease, Volume 28, Issue 5, September/October 2026.
Among 135 cases of post‐liver transplant HHV8 disease (4 from NSW), presentations varied, and mortality was high (44%). Donor screening was rare, and donor‐derived infection was suspected in 33%. Survival improved with mTORi, reduced immunosuppression, chemotherapy, and, for non‐KS disease, donor screening. ABSTRACT Background Human herpesvirus 8 (HHV8)
Karen M. J. Waller, Sudarshan Arvind, Simone I. Strasser, Ken Liu, Geoff W. McCaughan, David G. Bowen, Madeleine Gill, Rebecca Davis, William Rawlinson, Sacha Stelzer‐Braid, Geoff Watson, Vinay Vanguru, Tina Marinelli   +12 more
wiley   +1 more source

Foscarnet Decreases Human Immunodeficiency Virus RNA [PDF]

, 2017
Foscarnet inhibits human immunodeficiency virus (HIV) replication in vitro and decreases p24 antigenemia in patients with cytomegalovirus (CMV) retinitis.
Kaiser, Laurent, Yerly, Sabine, Furrer, Hansjakob, Hirschel, Bernard, Olmari, Maya, Perrin, Luc, Von Overbeck, Jan   +6 more
core  

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Removal of Foscarnet by Hemodialysis using Dialysate-Side Values

, 2000
Foscarnet is an antiviral agent widely used in the treatment of cytomegalovirus (CMV) infection. We describe a cardiac transplant patient, who while being maintained with hemodialysis because of tobramycin-induced acute renal failure, was given ...
J.G. Gambertoglio, D.J. Leehey, S.B. Patel, A. Popli, T.S. Ing, R. Sam   +5 more
core   +1 more source

Central Nervous System Infections in Pediatric Solid Organ Transplant Recipients

Pediatric Transplantation, Volume 30, Issue 8, August 2026.
CNS infections in SOT recipients are rare and presentation can be subtle. Therefore, a low threshold for evaluation is warranted to minimize the associated mortality. ABSTRACT Background Solid organ transplant (SOT) recipients face an increased risk of central nervous system (CNS) infections due to immunosuppression.
Amna AlSaihati, Kathleen E. Hosek, Cristina Otero, Brandon H. Tran, Carrie A. Mohila, David Moreno McNeill, Mini Michael, Krupa R. Mysore, Joseph A. Spinner, Claire E. Bocchini, Kristen G. Valencia Deray   +10 more
wiley   +1 more source

Herpes simplex virus-1 entrapped in Candida albicans biofilm displays decreased sensitivity to antivirals and UVA1 laser treatment

Annals of Clinical Microbiology and Antimicrobials, 2017
Background Recently, we published data suggesting a mutualistic relationship between HSV-1 and Candida. albicans; in particular: (a) HSV-1 infected macrophages are inhibited in their anti-Candida effector function and (b) Candida biofilm protects HSV-1 ...
Cristian Ascione, Arianna Sala, Elham Mazaheri-Tehrani, Simona Paulone, Beniamino Palmieri, Elisabetta Blasi, Claudio Cermelli   +6 more
doaj   +1 more source

Surveillance of CMV Terminase Gene Mutations in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Letermovir (LMV), a CMV‐specific terminase inhibitor, is recommended for cytomegalovirus (CMV) prophylaxis in CMV‐seropositive allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. The association between low‐level CMV DNAemia during prophylaxis and the emergence of mutations in CMV terminase complex genes remains unclear.
Amandine Caillault, Alienor Xhaard, Severine Mercier‐Delarue, Linda Feghoul, Julien Robert, Nathalie Schnepf, David Michonneau, Marie Robin, Flore Sicre de Fontbrune, Eleonore Kaphan, Mathilde Ruggiu‐Goiran, Pedro Henrique de Lima Prata, Florian Chevillon, Matthieu Jestin, Nathalie Dhedin, Gerard Socie, Régis Peffault de Latour, Maud Salmona, Jérôme LeGoff   +18 more
wiley   +1 more source

GCV-resistant CMV treated by foscarnet

, 2016
Cytomegalovirus (CMV) infection is themost common infectious complication following solid organ transplantation. Ganciclovir (GCV)-resistant CMV infection may be fatal, and is difficult to treat while avoiding allograft rejection.
Morita, Ken, Oishi, Yuichiro, Fujita, Hiromi, Iwami, Daiki, Shinohara, Nobuo, Ogawa, Yayoi, Sasaki, Hajime, Higuchi, Haruka, Hatanaka, Kanako   +8 more
core   +1 more source

Phenotypic characterisation of cytomegalovirus DNA polymerase: a method to study cytomegalovirus isolates resistant to foscarnet [PDF]

, 2005
International audienceA phenotypic method was developed to test mutations in the human cytomegalovirus (HCMV) DNA polymerase gene (UL54) suspected to confer resistance to foscarnet. This method was used to determine the biochemical phenotype of wild-type
A.M. Fillet, Mazeron, Marie-Christine, M.C. Mazeron, Petit, Françoise, M.J. Sanson Le Pors, Alain, Sophie, A. Ducancelle, F. Petit, Gravisse, Jérôme, J. Gravisse, Fillet, Anne-Marie, S. Alain, Ducancelle, Alexandra, Pors, Marie-José Sanson Le   +13 more
core   +1 more source