Results 1 to 10 of about 146,477 (113)
Strategies and efforts in circumventing the emergence of antiviral resistance against conventional antivirals [PDF]
npj Antimicrobials and ResistanceAntiviral resistance stemming from rapid viral evolution and adaptation is a major challenge faced in treating viral infections. Here, we describe the mechanisms and factors underlying antiviral resistance and their implications to future drug ...
Daryl Zheng Hao Aw +2 more
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Preparing for the Next Influenza Season: Monitoring the Emergence and Spread of Antiviral Resistance [PDF]
Infection and Drug Resistance, 2023 Djin-Ye Oh, Jeanette Milde, Youngsun Ham, Julia Patricia Ramos Calderón, Marianne Wedde, Ralf Dürrwald, Susanne C Duwe Robert Koch Institute, Department 1: Infectious Diseases, Unit 17: Influenza and Other Respiratory Viruses, National Influenza Center ...
Oh DY +6 more
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Defensin-like Protein Homologues Participate in Antiviral Resistance in Nicotiana benthamiana [PDF]
LifePlant defensin-like proteins, as the core effector molecules of innate immunity, play an important role in resistance against fungi and bacteria. However, their function in plant antiviral resistance remains unclear.
Jiaxin Xu +12 more
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Wastewater-Based Genomic Surveillance of SARS-CoV-2 Antiviral Resistance Determinants in Ontario: Towards a Scalable Framework for Population-Level Antiviral Resistance Monitoring [PDF]
VirusesBackground: Wastewater surveillance has emerged as an effective tool for population-level pathogen monitoring. Its application to mutations associated with resistance to antivirals remains comparatively underdeveloped.
Opeyemi U. Lawal +10 more
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Clinical Implications of Antiviral Resistance in Influenza
Viruses, 2015 Influenza is a major cause of severe respiratory infections leading to excessive hospitalizations and deaths globally; annual epidemics, pandemics, and sporadic/endemic avian virus infections occur as a result of rapid, continuous evolution of influenza ...
Timothy C. M. Li +2 more
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Viruses, 2021 Hemagglutinin and neuraminidase, which constitute the glycoprotein spikes expressed on the surface of influenza A and B viruses, are the most exposed parts of the virus and play critical roles in the viral lifecycle.
Yaqin Bai +3 more
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Enhanced In Vitro Antiviral Activity of Hydroxychloroquine Ionic Liquids against SARS-CoV-2
Pharmaceutics, 2022 The development of effective antiviral drugs against SARS-CoV-2 is urgently needed and a global health priority. In light of the initial data regarding the repurposing of hydroxychloroquine (HCQ) to tackle this coronavirus, herein we present a ...
Francisco Faísca +5 more
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Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir
Microorganisms, 2021 Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics.
Chiara Medaglia +6 more
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Pathogens, 2022 Baloxavir marboxil (BXM) is an antiviral drug that targets the endonuclease of the influenza polymerase acidic (PA) protein. Antiviral resistance, mainly mediated by the I38T PA substitution, readily occurs in both A(H1N1) and A(H3N2) viruses following a
Amel Saim-Mamoun +3 more
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Computational and Structural Biotechnology Journal, 2020 There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The beta-CoV Spike protein is a promising target considering the critical role in viral infection and pathogenesis and its surface exposed features. We performed a structure-
João Trigueiro-Louro +4 more
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