Results 11 to 20 of about 241,460 (301)
Clinical Implications of Antiviral Resistance in Influenza
Viruses, 2015 Influenza is a major cause of severe respiratory infections leading to excessive hospitalizations and deaths globally; annual epidemics, pandemics, and sporadic/endemic avian virus infections occur as a result of rapid, continuous evolution of influenza ...
Timothy C. M. Li +2 more
doaj +3 more sources
Antiviral Drug Resistance of Human Cytomegalovirus [PDF]
Clinical Microbiology Reviews, 2010 SUMMARYThe study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced knowledge of the virological targets and the mechanisms of antiviral activity. The currently approved drugs, ganciclovir (GCV), foscarnet (FOS), and cidofovir (CDV), target the viral DNA polymerase.
Nell S, Lurain, Sunwen, Chou
openaire +4 more sources
Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents [PDF]
, 2014 Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes.
A Owsianka +72 more
core +10 more sources
Pathogens, 2022 Baloxavir marboxil (BXM) is an antiviral drug that targets the endonuclease of the influenza polymerase acidic (PA) protein. Antiviral resistance, mainly mediated by the I38T PA substitution, readily occurs in both A(H1N1) and A(H3N2) viruses following a
Amel Saim-Mamoun +3 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2020 There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The beta-CoV Spike protein is a promising target considering the critical role in viral infection and pathogenesis and its surface exposed features. We performed a structure-
João Trigueiro-Louro +4 more
doaj +1 more source
Structure-activity relationships of fluorene compounds inhibiting HCV variants [PDF]
, 2020 Approximately 71 million people suffer from hepatitis C virus (HCV) infection worldwide. Persistent HCV infection causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, resulting in approximately 400,000 deaths ...
Gadhe, Changdev G. +10 more
core +1 more source
Antiviral drugs and antiviral drug resistance [PDF]
Current Opinion in Virology, 2011 Antiviral drugs and antiviral drug resistance can be matters of life and death for patients suffering from viral infections. They also can be valuable tools for understanding virus biology and biochemistry. Triumphs of antiviral therapy include acyclovir to treat genital herpes [1–4], triple combination chemotherapy for AIDS [5,6], and, quite recently,
Donald M, Coen, Richard J, Whitley
openaire +2 more sources
BMJ, 1998 The development of effective antiviral drugs is an important biomedical scientific achievement of the late 20th century. Highly potent drugs are now available against herpes viruses, HIV, hepatitis B virus, and influenza virus. This list will extend to papillomaviruses, respiratory viruses, enteroviruses, and hepatitis C virus over the next 5-10 years.
D, Pillay, M, Zambon
openaire +4 more sources
A Compensatory Mutation Provides Resistance to Disparate HIV Fusion Inhibitor Peptides and Enhances Membrane Fusion [PDF]
, 2013 Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors being developed, including the drug enfuvirtide, are peptides designed to competitively inhibit the viral fusion protein ...
A Adachi +41 more
core +8 more sources
Retrovirology, 2017 The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells.
Guoli Shi +2 more
doaj +1 more source