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Influenza viruses – antiviral therapy and resistance [PDF]
Influenza is a serious and frequently underestimated, but vaccine preventable disease. The adamantane derivates rimantadine and amantadine and the neuraminidase inhibitors zanamivir and oseltamivir are the only antiviral drugs currently approved in ...
Duwe, Susanne
doaj +6 more sources
PURPOSE OF REVIEW Current genotypic resistance tests fail to amplify drug-resistant minority variants when they are present below 20% of the total virus population.
Smit, Erasmus
core +3 more sources
Antiviral drugs and antiviral drug resistance [PDF]
Antiviral drugs and antiviral drug resistance can be matters of life and death for patients suffering from viral infections. They also can be valuable tools for understanding virus biology and biochemistry. Triumphs of antiviral therapy include acyclovir to treat genital herpes [1–4], triple combination chemotherapy for AIDS [5,6], and, quite recently,
Donald M, Coen, Richard J, Whitley
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ARHAI: antiviral resistance [PDF]
Development of antiviral resistance is a particular concern for the Advisory Committee on Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI). Over the last 4 years, considerable time has been devoted to examining the ability of the UK to monitor the presence and transmission of antiviral resistance. Resistances to antiviral agents in
C Y William, Tong +2 more
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The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells.
Guoli Shi +2 more
doaj +1 more source
Population-Wide Emergence of Antiviral Resistance during Pandemic Influenza [PDF]
Background: The emergence of neuraminidase inhibitor resistance has raised concerns about the prudent use of antiviral drugs in response to the next influenza pandemic.
Wu, Jianhong +13 more
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Hepatitis B virus (HBV) is a highly variable DNA virus due to its unique life cycle, which involves an error-prone reverse transcriptase. The high substitution rate drives the evolution of HBV by generating genetic variants upon which selection operates.
Natalia M. Araujo +2 more
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Options for the management of antiviral resistance during hepatitis B therapy: reflections on battles over a decade [PDF]
Although much advancement has been achieved in the treatment of chronic hepatitis B, antiviral resistance is still a challenging issue. Previous generation antiviral agents have already developed resistance in a number of patients, and it is still being ...
Hyung Joon Yim, Seong Gyu Hwang
doaj +1 more source
New Treatment Options for Refractory/Resistant CMV Infection
Despite advances in monitoring and treatment, cytomegalovirus (CMV) infections remain one of the most common complications after solid organ transplantation (SOT).
Carla Simone Walti +3 more
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Molecular Basis of Encapsidation of Hepatitis C Virus Genome
Hepatitis C virus (HCV), a major etiologic agent of human liver diseases, is a positive-sense single-stranded RNA virus and is classified in the Flaviviridae family.
Guoli Shi, Tetsuro Suzuki
doaj +1 more source

