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Influenza viruses – antiviral therapy and resistance [PDF]

open access: yesGMS Infectious Diseases, 2017
Influenza is a serious and frequently underestimated, but vaccine preventable disease. The adamantane derivates rimantadine and amantadine and the neuraminidase inhibitors zanamivir and oseltamivir are the only antiviral drugs currently approved in ...
Duwe, Susanne
doaj   +6 more sources

Antiviral resistance testing.

open access: yesCurrent Opinion in Infectious Diseases, 2014
PURPOSE OF REVIEW Current genotypic resistance tests fail to amplify drug-resistant minority variants when they are present below 20% of the total virus population.
Smit, Erasmus
core   +3 more sources

Antiviral drugs and antiviral drug resistance [PDF]

open access: yesCurrent Opinion in Virology, 2011
Antiviral drugs and antiviral drug resistance can be matters of life and death for patients suffering from viral infections. They also can be valuable tools for understanding virus biology and biochemistry. Triumphs of antiviral therapy include acyclovir to treat genital herpes [1–4], triple combination chemotherapy for AIDS [5,6], and, quite recently,
Donald M, Coen, Richard J, Whitley
openaire   +2 more sources

ARHAI: antiviral resistance [PDF]

open access: yesJournal of Antimicrobial Chemotherapy, 2012
Development of antiviral resistance is a particular concern for the Advisory Committee on Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI). Over the last 4 years, considerable time has been devoted to examining the ability of the UK to monitor the presence and transmission of antiviral resistance. Resistances to antiviral agents in
C Y William, Tong   +2 more
openaire   +2 more sources

More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins

open access: yesRetrovirology, 2017
The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells.
Guoli Shi   +2 more
doaj   +1 more source

Population-Wide Emergence of Antiviral Resistance during Pandemic Influenza [PDF]

open access: yes, 2008
Background: The emergence of neuraminidase inhibitor resistance has raised concerns about the prudent use of antiviral drugs in response to the next influenza pandemic.
Wu, Jianhong   +13 more
core   +2 more sources

Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region

open access: yesFrontiers in Microbiology, 2020
Hepatitis B virus (HBV) is a highly variable DNA virus due to its unique life cycle, which involves an error-prone reverse transcriptase. The high substitution rate drives the evolution of HBV by generating genetic variants upon which selection operates.
Natalia M. Araujo   +2 more
doaj   +1 more source

Options for the management of antiviral resistance during hepatitis B therapy: reflections on battles over a decade [PDF]

open access: yesClinical and Molecular Hepatology, 2013
Although much advancement has been achieved in the treatment of chronic hepatitis B, antiviral resistance is still a challenging issue. Previous generation antiviral agents have already developed resistance in a number of patients, and it is still being ...
Hyung Joon Yim, Seong Gyu Hwang
doaj   +1 more source

New Treatment Options for Refractory/Resistant CMV Infection

open access: yesTransplant International, 2023
Despite advances in monitoring and treatment, cytomegalovirus (CMV) infections remain one of the most common complications after solid organ transplantation (SOT).
Carla Simone Walti   +3 more
doaj   +1 more source

Molecular Basis of Encapsidation of Hepatitis C Virus Genome

open access: yesFrontiers in Microbiology, 2018
Hepatitis C virus (HCV), a major etiologic agent of human liver diseases, is a positive-sense single-stranded RNA virus and is classified in the Flaviviridae family.
Guoli Shi, Tetsuro Suzuki
doaj   +1 more source

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