Results 41 to 50 of about 241,460 (301)

Antivirals Targeting the Surface Glycoproteins of Influenza Virus: Mechanisms of Action and Resistance

Viruses, 2021
Hemagglutinin and neuraminidase, which constitute the glycoprotein spikes expressed on the surface of influenza A and B viruses, are the most exposed parts of the virus and play critical roles in the viral lifecycle.
Yaqin Bai, Jeremy C. Jones, Sook-San Wong, Mark Zanin   +3 more
doaj   +1 more source

Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease [PDF]

, 2015
Hepatitis B virus (HBV) infection is a dynamic state of interactions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B (CHB) infection have shown an association between active viral replication and adverse
Farinati, Fabio, Gottardo, G, Rodr\uedguez Castro, K, Russo, FRANCESCO PAOLO, Scribano, L, Vanin, V   +5 more
core   +1 more source

Options for the management of antiviral resistance during hepatitis B therapy: reflections on battles over a decade [PDF]

Clinical and Molecular Hepatology, 2013
Although much advancement has been achieved in the treatment of chronic hepatitis B, antiviral resistance is still a challenging issue. Previous generation antiviral agents have already developed resistance in a number of patients, and it is still being ...
Hyung Joon Yim, Seong Gyu Hwang
doaj   +1 more source

Surveillance for antiviral resistance [PDF]

Influenza and Other Respiratory Viruses, 2012
Please cite this paper as: Zambon. (2012) Surveillance for antiviral resistance. Influenza and Other Respiratory Viruses 7(Suppl. 1), 37–43.In the 10 years since licensure of neuraminidase inhibitor drugs, their use has steadily increased, especially during the pandemic of 2009.
openaire   +2 more sources

In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]

, 2005
Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ, Bray, PG, Chandler, B, Hart, CA, Hartkoorn, RC, Janneh, O, Khoo, SH, Martin, P, Owen, A, Ward, SA   +9 more
core   +1 more source

Antiviral Agents: Discovery to Resistance [PDF]

Viruses, 2020
In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]
openaire   +4 more sources

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Influenza antivirals: efficacy and resistance [PDF]

Influenza and Other Respiratory Viruses, 2012
The inaugural conference of the Antiviral Group of the International Society for Influenza and other Respiratory Virus Diseases (ISIRV-AVG) was organised in conjunction with the Oswaldo Cruz Foundation (FIOCRUZ) in Rio de Janeiro, Brazil, in November 2011.
Marilda, Siqueira, Alan, Hay
openaire   +2 more sources

Whole genome analysis of hepatitis B virus before and during long-term therapy in chronic infected patients: Molecular characterization, impact on treatment and liver disease progression

Frontiers in Microbiology, 2022
Hepatitis B virus (HBV) infection remains a serious public health concern worldwide despite the availability of an efficient vaccine and the major improvements in antiviral treatments.
Zeineb Belaiba, Zeineb Belaiba, Kaouther Ayouni, Kaouther Ayouni, Mariem Gdoura, Mariem Gdoura, Wafa Kammoun Rebai, Henda Touzi, Amel Sadraoui, Walid Hammemi, Lamia Yacoubi, Salwa Abdelati, Lamine Hamzaoui, Mohamed Msaddak Azzouz, Anissa Chouikha, Anissa Chouikha, Henda Triki, Henda Triki   +17 more
doaj   +1 more source

The RNA-Binding Domain NS1 of Influenza as an Antiviral Target: From Evolutionary Conservation Mapping to Experimental Validation

Viruses
Non-structural protein 1 (NS1) of influenza A virus is a multifunctional virulence factor and represents a promising anti-influenza target, considering its conserved and druggable structure.
Luis André Santos, João Trigueiro-Louro, Helena Rebelo-de-Andrade   +2 more
doaj   +1 more source