Results 61 to 70 of about 2,451,260 (295)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Artificial Small RNA-Based Silencing Tools for Antiviral Resistance in Plants

Plants, 2020
Artificial small RNAs (art-sRNAs), such as artificial microRNAs (amiRNAs) and synthetic trans-acting small interfering RNAs (syn-tasiRNAs), are highly specific 21-nucleotide small RNAs designed to recognize and silence complementary target RNAs.
Adriana E. Cisneros, Alberto Carbonell
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Avaliação da citotoxicidade, da genotoxicidade e da potencial atividade antiviral da violaceína, produzida pela Chromobacterium violaceum [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.Os produtos naturais constituem uma fonte inesgotável de compostos com atividades farmacológicas promissoras, incluindo ...
Fröhner, Carla Regina Andrighetti
core  

Antiviral Res.

, 2014
Recombinant human interferon-omega (rhIFN-omega) exhibits a potent antiviral activity. Because of poor pharmacokinetics (PK) of rhIEN-omega, frequent dosing of rhIFN-omega is necessitated to achieve the sustained antiviral efficacy.
Fang, Ting, Chen, Wei, Yu, Weili, Hu, Tao, Wu, Ling, Zhang, Jinlong, Yu, Changming, Qiu, Rui, Fu, Ling, Yu, Ting   +9 more
core   +1 more source

Effect of Baloxavir and Oseltamivir in Combination on Infection with Influenza Viruses with PA/I38T or PA/E23K Substitutions in the Ferret Model

mBio, 2022
Amino acid substitutions I38T and E23K in the influenza polymerase acidic (PA) protein lead to reduced susceptibility to the influenza antiviral drug baloxavir.
Paulina Koszalka, Ankita George, Vijaykrishna Dhanasekaran, Aeron C. Hurt, Kanta Subbarao   +4 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A., Boyd, A, Fazakerley, John K., Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, J. K. Fazakerley, Elliott, Richard M, Boyd, Amanda, H. Streitenfeld, Elliott, R.M., Streitenfeld, H., A. Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J K, Fazakerley, J.K., F. Weber, R. M. Elliott, Bridgen, A, Elliott, Richard Michael, Bridgen, Anne, A. Boyd   +25 more
core   +1 more source

Cu/Zn superoxide dismutase homologs participate in Nicotiana benthamiana antiviral responses

Frontiers in Microbiology
Superoxide dismutases (SODs) serve as the first line of defense against reactive oxygen species. Copper-zinc superoxide dismutase (Cu/Zn-SOD) is an enzyme whose activity depends on copper availability. Cu/Zn-SOD-1 induction is shown to be involved in the
Haijuan Wang, Jidan Zhang, Zhuo Meng, Zhenqi Sun, Dongyang Liu, Bin Li, Fangfang Yan, Chongyi Jia, Hongyou Zhou, Hongyou Zhou, Mingmin Zhao, Mingmin Zhao   +11 more
doaj   +1 more source

Efforts to Identify and Combat Antimicrobial Resistance in Uganda: A Systematic Review

Tropical Medicine and Infectious Disease, 2021
The global burden of antimicrobial resistance is on the rise, resulting in higher morbidity and mortality in our communities. The spread of antimicrobial resistance in the environment and development of resistant microbes is a challenge to the control of
Mark Tefero Kivumbi, Claire J. Standley
doaj   +1 more source