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Influenza Neuraminidase Characteristics and Potential as a Vaccine Target

Frontiers in Immunology, 2021
Neuraminidase of influenza A and B viruses plays a critical role in the virus life cycle and is an important target of the host immune system. Here, we highlight the current understanding of influenza neuraminidase structure, function, antigenicity ...
Sarah Creytens, Sarah Creytens, Mirte N. Pascha, Marlies Ballegeer, Marlies Ballegeer, Xavier Saelens, Xavier Saelens, Cornelis A. M. de Haan   +7 more
doaj   +2 more sources

A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

mBio, 2021
Current seasonal influenza virus vaccines do not induce robust immune responses to neuraminidase. Several factors, including immunodominance of hemagglutinin over neuraminidase, instability of neuraminidase in vaccine formulations, and variable ...
Shirin Strohmeier, Fatima Amanat, Xueyong Zhu, Meagan McMahon, Meagan E. Deming, Marcela F. Pasetti, Kathleen M. Neuzil, Ian A. Wilson, Florian Krammer   +8 more
doaj   +2 more sources

NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?

mBio, 2018
Neuraminidase is one of the two surface glycoproteins of influenza A and B viruses. It has enzymatic activity that cleaves terminal sialic acid from glycans, and that activity is essential at several points in the virus life cycle. While neuraminidase is
Florian Krammer, Ron A. M. Fouchier, Maryna C. Eichelberger, Richard J. Webby, Kathryn Shaw-Saliba, Hongquan Wan, Patrick C. Wilson, Richard W. Compans, Ioanna Skountzou, Arnold S. Monto   +9 more
doaj   +2 more sources

Mucosal Immunity against Neuraminidase Prevents Influenza B Virus Transmission in Guinea Pigs

mBio, 2019
Despite efforts to control influenza virus infection and transmission, influenza viruses still cause significant morbidity and mortality in the global human population each year.
Meagan McMahon, Ericka Kirkpatrick, Daniel Stadlbauer, Shirin Strohmeier, Nicole M. Bouvier, Florian Krammer   +5 more
doaj   +2 more sources

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children [PDF]

Sao Paulo medical journal = Revista paulista de medicina, 2014
BACKGROUND: Neuraminidase inhibitors (NIs) are stockpiled and recommended by public health agencies for treating and preventing seasonal and pandemic influenza. They are used clinically worldwide.
Del Mar, Chris B., Doshi, Peter, Hama, Rokuro, Heneghan, Carl J., Howick, Jeremy, Jefferson, Tom, Jones, Mark A., Mahtani, Kamal R., Nunan, David, Onakpoya, Igho, Spencer, Elizabeth A., Thompson, Matthew J.   +11 more
core   +2 more sources

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

mBio, 2017
Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity
Madhusudan Rajendran, Raffael Nachbagauer, Megan E. Ermler, Paul Bunduc, Fatima Amanat, Ruvim Izikson, Manon Cox, Peter Palese, Maryna Eichelberger, Florian Krammer   +9 more
doaj   +2 more sources

Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity

Molecules, 2016
Despite being a common viral disease, influenza has very negative consequences, causing the death of around half a million people each year. A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing
Pedro Laborda, Su-Yan Wang, Josef Voglmeir   +2 more
doaj   +2 more sources

Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

Cell Host and Microbe, 2019
Influenza virus neuraminidase (NA) is a major target for small-molecule antiviral drugs. Antibodies targeting the NA surface antigen could also inhibit virus entry and egress to provide host protection.
Xueyong Zhu, Hannah L Turner, Ryan McBride   +2 more
exaly   +2 more sources

Neuraminidase-activated microglia compromise the viability of ependymocytes [PDF]

, 2017
Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ependymal detachment and death,
Carrillo-Pinzon, Cristobal, Fernandez-Arjona, Mar, Fernández-Llebrez, Pedro, Grondona, Jesús M, López-Ávalos, María Dolores   +4 more
core   +2 more sources

Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data

Lancet Respiratory Medicine,the, 2014
BACKGROUND Neuraminidase inhibitors were widely used during the 2009-10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain.
Sudhir Venkatesan, Jo Leonardi-Bee, Ashish P Anovadiya   +2 more
exaly   +2 more sources