Results 1 to 10 of about 53,295 (182)

R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Emerging Infectious Diseases, 2013
Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors ...
Katrina Sleeman, Zhu Guo, John Barnes, Michael Shaw, James Stevens, Larisa V. Gubareva   +5 more
doaj   +1 more source

The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases

Frontiers in Endocrinology, 2022
The incidence of cardiovascular diseases is increasing worldwide with the growing aging of the population. Biological aging has major influence on the vascular tree and is associated with critical changes in the morphology and function of the arterial ...
Dignê Tembely, Aubéri Henry, Laetitia Vanalderwiert, Kevin Toussaint, Amar Bennasroune, Sébastien Blaise, Hervé Sartelet, Stéphane Jaisson, Céline Galés, Laurent Martiny, Laurent Duca, Béatrice Romier-Crouzet, Pascal Maurice   +12 more
doaj   +1 more source

Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay–Sachs mouse models

Molecular Genetics and Metabolism Reports, 2015
Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA−/− mice, depleted of the β-Hexosaminidase A iso-enzyme,
Z.K. Timur, S. Akyildiz Demir, C. Marsching, R. Sandhoff, V. Seyrantepe   +4 more
doaj   +1 more source

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

mBio, 2017
Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity
Madhusudan Rajendran, Raffael Nachbagauer, Megan E. Ermler, Paul Bunduc, Fatima Amanat, Ruvim Izikson, Manon Cox, Peter Palese, Maryna Eichelberger, Florian Krammer   +9 more
doaj   +1 more source

Influenza’s Newest Trick

mBio, 2019
Influenza A viruses are important pathogens for humans and for many birds and mammals. Hemagglutinin and neuraminidase are the major surface proteins of this enveloped RNA virus. Hemagglutinin requires proteolytic cleavage for activation, but because the
Jeffery K. Taubenberger
doaj   +1 more source

Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses

mBio, 2023
Immune imprinting is a driver known to shape the anti-hemagglutinin (HA) antibody landscape of individuals born within the same birth cohort. With the HA and neuraminidase (NA) proteins evolving at different rates under immune selection pressures, anti ...
Pavithra Daulagala, Brian R. Mann, Kathy Leung, Eric H. Y. Lau, Louise Yung, Ruipeng Lei, Sarea I. N. Nizami, Joseph T. Wu, Susan S. Chiu, Rodney S. Daniels, Nicholas C. Wu, David Wentworth, Malik Peiris, Hui-Ling Yen   +13 more
doaj   +1 more source

Method for evaluating the neuraminidase activity of receptor-destroying enzyme (RDE) compounds using the influenza virus

Вопросы вирусологии, 2020
Introduction. The classic hemagglutination inhibition reaction (RTGA) is used to determine the level of antiviral antibodies in human and animal serum specimens.
Artem Yu. Fedorov, Oleg P. Zhirnov
doaj   +1 more source

Antigenic Characterization of Neuraminidase of Influenza A/H7N9 Viruses Isolated in Different Years

Pharmaceuticals, 2022
Influenza outbreaks caused by A/H7N9 viruses have occurred since 2013. After 2016, A/H7N9 influenza viruses underwent evolutionary changes. In this study, we examined the antigenic properties of influenza neuraminidase (NA) of A/H7N9 viruses as part of a
Yulia Desheva, Igor Losev, Nadezhda Petkova, Polina Kudar, Svetlana Donina, Andrey Mamontov, Chih-Hsuan Tsai, Yu-Chan Chao   +7 more
doaj   +1 more source

In Silico Studies Reveal Peramivir and Zanamivir as an Optimal Drug Treatment Even If H7N9 Avian Type Influenza Virus Acquires Further Resistance

Molecules, 2022
An epidemic of avian type H7N9 influenza virus, which took place in China in 2013, was enhanced by a naturally occurring R294K mutation resistant against Oseltamivir at the catalytic site of the neuraminidase.
Edita Sarukhanyan, Tipack Ayothyapattanam Shanmugam, Thomas Dandekar   +2 more
doaj   +1 more source

Current Approaches for Diagnosis of Influenza Virus Infections in Humans

Viruses, 2016
Despite significant advancement in vaccine and virus research, influenza continues to be a major public health concern. Each year in the United States of America, influenza viruses are responsible for seasonal epidemics resulting in over 200,000 ...
Sai Vikram Vemula, Jiangqin Zhao, Jikun Liu, Xue Wang, Santanu Biswas, Indira Hewlett   +5 more
doaj   +1 more source