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Hemagglutinin Structure and Activities [PDF]

Cold Spring Harbor Perspectives in Medicine, 2020
Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus attachment to cells requires their interaction with several virus HAs. Receptor-bound virus is transferred
Steven J, Gamblin, Sébastien G, Vachieri, Xiaoli, Xiong, Jie, Zhang, Stephen R, Martin, John J, Skehel   +5 more
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A Bivalent Human Adenovirus Type 5 Vaccine Expressing the Rabies Virus Glycoprotein and Canine Distemper Virus Hemagglutinin Protein Confers Protective Immunity in Mice and Foxes

Frontiers in Microbiology, 2020
The development of a safe and efficient multivalent vaccine has great prospects for application. Both rabies virus (RABV) and canine distemper virus (CDV) are highly infectious antigens, causing lethal diseases in domestic dogs and other carnivores ...
Lina Yan, Zhongxin Zhao, Xianghong Xue, Wenwen Zheng, Tong Xu, Lele Liu, Li Tian, Xianwei Wang, Hongbin He, Xuexing Zheng   +9 more
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An Overview of Influenza Viruses and Vaccines

Vaccines, 2021
Influenza remains one of the major public health concerns because it causes annual epidemics and can potentially instigate a global pandemic. Numerous countermeasures, including vaccines and antiviral treatments, are in use against seasonal influenza ...
Rina Fajri Nuwarda, Abdulsalam Abdullah Alharbi, Veysel Kayser   +2 more
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Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions

Viruses, 2021
In current seasonal influenza vaccines, neutralizing antibody titers directed against the hemagglutinin surface protein are the primary correlate of protection. These vaccines are, therefore, quantitated in terms of their hemagglutinin content.
Nidhi Mittal, Nayanika Sengupta, Sameer Kumar Malladi, Poorvi Reddy, Madhuraj Bhat, Raju S. Rajmani, Koen Sedeyn, Xavier Saelens, Somnath Dutta, Raghavan Varadarajan   +9 more
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Influenza A Virus Hemagglutinin Trimer, Head and Stem Proteins Identify and Quantify Different Hemagglutinin-Specific B Cell Subsets in Humans

Vaccines, 2021
Antibody responses against the influenza A virus hemagglutinin (HA)-protein are studied intensively because they can protect against (re)infection. Previous studies have focused on antibodies targeting the head or stem domains, while other possible ...
Aafke Aartse, Dirk Eggink, Mathieu Claireaux, Sarah van Leeuwen, Petra Mooij, Willy M. Bogers, Rogier W. Sanders, Gerrit Koopman, Marit J. van Gils   +8 more
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Influenza hemagglutinin membrane anchor [PDF]

Proceedings of the National Academy of Sciences, 2018
Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies.
Donald J. Benton, Andrea Nans, Lesley J. Calder, Jack Turner, Ursula Neu, Yi Pu Lin, Esther Ketelaars, Nicole L. Kallewaard, Davide Corti, Antonio Lanzavecchia, Steven J. Gamblin, Peter B. Rosenthal, John J. Skehel   +12 more
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Characterization of Hemagglutinin Negative Botulinum Progenitor Toxins

Toxins, 2017
Botulism is a disease involving intoxication with botulinum neurotoxins (BoNTs), toxic proteins produced by Clostridium botulinum and other clostridia. The 150 kDa neurotoxin is produced in conjunction with other proteins to form the botulinum progenitor
Suzanne R. Kalb, Jakub Baudys, Theresa J. Smith, Leonard A. Smith, John R. Barr   +4 more
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Exploiting Pan Influenza A and Pan Influenza B Pseudotype Libraries for Efficient Vaccine Antigen Selection

Vaccines, 2021
We developed an influenza hemagglutinin (HA) pseudotype library encompassing Influenza A subtypes HA1-18 and Influenza B subtypes (both lineages) to be employed in influenza pseudotype microneutralization (pMN) assays.
Joanne Marie M. Del Rosario, Kelly A. S. da Costa, Benedikt Asbach, Francesca Ferrara, Matteo Ferrari, David A. Wells, Gurdip Singh Mann, Veronica O. Ameh, Claude T. Sabeta, Ashley C. Banyard, Rebecca Kinsley, Simon D. Scott, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton   +15 more
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Influenza’s Newest Trick

mBio, 2019
Influenza A viruses are important pathogens for humans and for many birds and mammals. Hemagglutinin and neuraminidase are the major surface proteins of this enveloped RNA virus. Hemagglutinin requires proteolytic cleavage for activation, but because the
Jeffery K. Taubenberger
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Echinacea purpurea L. (Moench) Hemagglutinin Effect on Immune Response In Vivo

Plants, 2021
Echinacea purpurea L. (Moench) is used in traditional and conventional medicine. However, there is lack of data on the biological activities of primary plant metabolite lectins.
Gabrielė Balčiūnaitė-Murzienė, Zoja Miknienė, Ona Ragažinskienė, Nomeda Juodžiukynienė, Arūnas Savickas, Nijolė Savickienė, Dalia Pangonytė   +6 more
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