Results 11 to 20 of about 108,411 (200)

Pseudotype-based neutralization assays for influenza: a systematic analysis [PDF]

Frontiers in Immunology, 2015
The use of vaccination against the influenza virus remains the most effective method of mitigating the significant morbidity and mortality caused by this virus.
George William Carnell, Francesca eFerrara, Keith eGrehan, Craig Peter Thompson, Craig Peter Thompson, Craig Peter Thompson, Nigel James Temperton   +6 more
doaj   +2 more sources

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations.

PLoS ONE, 2018
The standard method to quantify the hemagglutinin content of influenza virus vaccines is the single radial immunodiffusion assay. This assay primarily relies on polyclonal antibodies against the head domain of the influenza virus hemagglutinin, which is ...
Madhusudan Rajendran, Weina Sun, Phillip Comella, Raffael Nachbagauer, Teddy John Wohlbold, Fatima Amanat, Ericka Kirkpatrick, Peter Palese, Florian Krammer   +8 more
doaj   +2 more sources

A Single Immunization with Soluble Recombinant Trimeric Hemagglutinin Protects Chickens against Highly Pathogenic Avian Influenza Virus H5N1 [PDF]

, 2010
Background: The highly pathogenic avian influenza (HPAI) virus H5N1 causes multi-organ disease and death in poultry, resulting in significant economic losses in the poultry industry.
Dep Infectieziekten Immunologie, Robert P de Vries, Vries, R.P., de, Rigter, A., Rottier, P.J.M., Cornelissen, A.H.M., de Vries, R.P., Cornelissen, L.A.H.M., Alan Rigter, Cornelis A M de Haan, Strategic Infection Biology, de Haan, C.A.M., Haan, C.A.M., de, de Boer-Luijtze, E.A., Boer-Luijtze, E.A., de, Lisette A H M Cornelissen, Els A de Boer-Luijtze, Peter J M Rottier   +17 more
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Detection of Antibodies against H5 and H7 strains in Birds: Evaluation of Influenza Pseudovirus Particle Neutralization Tests [PDF]

, 2014
Introduction: Avian influenza viruses circulate in bird populations, and it is important to maintain and uphold our knowledge of the viral strains that are currently of interest in this context.
Lundkvist, Åke,, Karlsson, Malin, Leijon, Mikael, Temperton, Nigel J, Lagerqvist, Nina, Cassmer, Michaela, Wallerström, Sofie, Moreno, Ana, Falk, Kerstin I, Cassmer, M, Leijon, M, Wallerström, S, Lundkvist, A, Moreno, A, Karlsson, M, Lagerqvist, N,, Temperton, NJ, Falk, KI, Temperton, Nigel J., Lundkvist, Åke, Falk, Kerstin   +20 more
core   +1 more source

Structural and functional relationship between the receptor recognition and neuraminidase activities of the Newcastle disease virus hemagglutinin-neuraminidase protein: Receptor recognition is dependent on neuraminidase activity [PDF]

, 2001
The terminal globular domain of the paramyxovirus hemagglutinin-neuraminidase (HN) glycoprotein spike has a number of conserved residues that are predicted to form its neuraminidase (NA) active site, by analogy to the influenza virus neuraminidase ...
Paul J. Mahon, Deng, R.T., Jennifer M. Sauvron, Langedijk, J.P., Anne M. Mirza, Gisela M. Field, Johannes P. Langedijk, Sauvron, J.M., Iorio, R.M., Field, G.M., Ruitang Deng, Mirza, A.M., Mahon, P.J., Ronald M. Iorio   +13 more
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Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]

, 2015
Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael, Ferrara, Francesca, Temperton, Nigel J., Flynn, Jessica A, Raghavan eVaradarajan, Vamsee Aditya Mallajosyula, V., Raghavan Varadarajan, Flynn, Jessica A., Temperton, Nigel J, Xiaoping eLiang, Vamsee Aditya Mallajosyula, V. Vamsee Aditya Mallajosyula, Michael Citron, Nigel J. Temperton, Xiaoping Liang, Mallajosyula, Vamsee Aditya V, Jessica A. Flynn, Liang, Xiaoping, Varadarajan, Raghavan, Michael eCitron, Francesca eFerrara, Nigel James Temperton, Jessica A Flynn, Francesca Ferrara, Mallajosyula, Vamsee V A   +24 more
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Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]

, 2016
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
Carnell, George, Temperton, Nigel J., Mallajosyula, VVA, Poon, Leo LM, Mallajosyula, V Vamsee Aditya, Temperton, N, Poon, LLM, Chin, Alex WH, Mallajosyula, VV, Chin, Alex W H, Carnell, G, Valkenburg, Sophie A, Li, OTW, Poon, Leo L M, Chin, WH, Mallajosyula, Vamsee Aditya V, Poon, LML, Li, Olive T W, Varadarajan, Raghavan, Doak, SA, Li, Olive TW, Temperton, Nigel, Chin, AWH, Valkenburg, SA, Varadarajan, R   +24 more
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The Role of Pili Protein 38,6 kDa Klebsiella pneumoniae as a Hemagglutinin and Adhesin Protein which Serves as a Virulence Factor

Journal of Agromedicine and Medical Sciences (AMS), 2019
Klebsiella pneumoniae is an infectious bacteria in various parts of the body. The presence of proteins in pili that will bind to cell surface receptors (adhesin proteins) and cell membrane sugar molecules (hemagglutinin proteins) is a very influential ...
Regina Finka, Dini Agustina, Dwita Aryadina Rachmawati, Enny Suswati, Diana Chusna Mufida, Ali Shodikin   +5 more
doaj   +1 more source

Intranasal immunization with a recombinant protein based on the M2e peptide and second subunit of influenza A viral hemagglutinin fragment induces a cross-protective humoral and Tcell response in mice

Медицинская иммунология, 2020
Development of vaccines with a broad-spectrum of protection is one of the priorities in the programs of influenza prevention. Recently, the conserved fragments of influenza virus proteins (M1, M2, NP, the second subunit of the hemagglutinin HA2) provoke ...
M. A Shuklina, L. A Stepanova, A. A. Kovaleva, A. V. Korotkov, A. A. Shaldzhyan, M. V. Zaitceva, E. I. Eletskaya, L. M. Tsybalova   +7 more
doaj   +1 more source

Influenza monitoring in Sardinia, Italy identifies H3 subtype in Mediterranean wild migratory birds

Journal of Infection in Developing Countries, 2012
Introduction: Wild migratory birds are global distributors of pathogens. Sardinia, Italy, is the second largest Island in the Mediterranean and is a land bridge between Europe and Africa.
Alyson Ann Kelvin, Dionigia Meloni, Paola Sansonetti, Ilaria Borghetto, Thomas Rowe, Rosaria Santangelo, Danilo Pisu, Cheryl M. Cameron, Bianca Paglietti, David Banner, Amber Farooqui, Patrizia Marongiu, Antonella Santona, Giovanni Fadda, David J. Kelvin, Salvatore Rubino   +15 more
doaj   +1 more source