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The Shifting Core: Antigenic Variability of the Influenza Virus Nucleoprotein Despite Evolutionary Conservation [PDF]

Antibodies
Background. The highly mutable influenza virus causes severe annual infections worldwide and results in substantial socioeconomic losses. The spread of infection could be effectively controlled by cross-protective vaccines and universal diagnostic test ...
Alexandra Rak, Veronika Muzurova, Svetlana Donina, Polina Prokopenko, Irina Isakova-Sivak, Larisa Rudenko   +5 more
doaj   +2 more sources

Immunogenicity of a DNA-Based Sindbis Replicon Expressing Crimean–Congo Hemorrhagic Fever Virus Nucleoprotein

Vaccines, 2021
Crimean–Congo hemorrhagic fever virus (CCHFV) infrequently causes hemorrhagic fever in humans with a case fatality rate of 30%. Currently, there is neither an internationally approved antiviral drug nor a vaccine against the virus.
Thomas Tipih, Mark Heise, Felicity Jane Burt   +2 more
doaj   +1 more source

A Novel Terrestrial Rabies Virus Lineage Occurring in South America: Origin, Diversification, and Evidence of Contact between Wild and Domestic Cycles

Viruses, 2021
The rabies virus (RABV) is characterized by a history dominated by host shifts within and among bats and carnivores. One of the main outcomes of long-term RABV maintenance in dogs was the establishment of variants in a wide variety of mesocarnivores.
Diego A. Caraballo, Cristina Lema, Laura Novaro, Federico Gury-Dohmen, Susana Russo, Fernando J. Beltrán, Gustavo Palacios, Daniel M. Cisterna   +7 more
doaj   +1 more source

Nucleoprotein as a Promising Antigen for Broadly Protective Influenza Vaccines

Vaccines, 2023
Annual vaccination is considered as the main preventive strategy against seasonal influenza. Due to the highly variable nature of major viral antigens, such as hemagglutinin (HA) and neuraminidase (NA), influenza vaccine strains should be regularly ...
Alexandra Rak, Irina Isakova-Sivak, Larisa Rudenko   +2 more
doaj   +1 more source

Molecular docking study of Zingiber officinale Roscoe compounds as a mumps virus nucleoprotein inhibitor

Dental Journal, 2023
Background: Mumps virus (MuV) can trigger severe infections, such as parotitis, epididymo-orchitis, and meningitis. The effectiveness of MuV vaccine administration has been proven, but current outbreaks warrant the development of antivirals against MuV ...
Viol Dhea Kharisma, Santika Lusia Utami, Wahyu Choirur Rizky, Tim Godefridus Antonius Dings, Md Emdad Ullah, Vikash Jakhmola, Alexander Patera Nugraha   +6 more
doaj   +1 more source

Structural insights on the nucleoprotein C-terminal domain of Měnglà virus

Microbiology Spectrum, 2023
Filoviruses depend on the nucleoprotein (NP) to accomplish multiple functions during the viral life cycle. NP is the most abundantly expressed viral protein in infected cells and the main component of the viral nucleocapsid.
Diego Sebastian Ferrero, Omar Tomás Gilabert, Nuria Verdaguer   +2 more
doaj   +1 more source

Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection

Viruses, 2023
Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause significant
Morgan R. Jennings, Robin J. Parks
doaj   +1 more source

Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111

Viruses, 2020
For highly pathogenic viruses, reporter assays that can be rapidly performed are critically needed to identify potentially functional mutations for further study under maximal containment (e.g., biosafety level 4 [BSL-4]).
Aaron E. Lin, William E. Diehl, Yingyun Cai, Courtney L. Finch, Chidiebere Akusobi, Robert N. Kirchdoerfer, Laura Bollinger, Stephen F. Schaffner, Elizabeth A. Brown, Erica Ollmann Saphire, Kristian G. Andersen, Jens H. Kuhn, Jeremy Luban, Pardis C. Sabeti   +13 more
doaj   +1 more source

A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and Attenuation

Biomolecules, 2022
The basic tenets of the shell disorder model (SDM) as applied to COVID-19 are that the harder outer shell of the virus shell (lower PID—percentage of intrinsic disorder—of the membrane protein M, PIDM) and higher flexibility of the inner shell (higher ...
Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, Vladimir N. Uversky   +3 more
doaj   +1 more source

Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein

Viruses, 2022
COVID-19 caused by SARS-CoV-2 is continuing to spread around the world and drastically affect our daily life. New strains appear, and the severity of the course of the disease itself seems to be decreasing, but even people who have been ill on an ...
Daria Matyushkina, Varvara Shokina, Polina Tikhonova, Valentin Manuvera, Dmitry Shirokov, Daria Kharlampieva, Vasily Lazarev, Anna Varizhuk, Tatiana Vedekhina, Alexander Pavlenko, Leonid Penkin, Georgij Arapidi, Konstantin Pavlov, Dmitry Pushkar, Konstantin Kolontarev, Alexander Rumyantsev, Sergey Rumyantsev, Lyubov Rychkova, Vadim Govorun   +18 more
doaj   +1 more source