Results 1 to 10 of about 91,004 (275)

Human Parainfluenza Virus 3 Phosphoprotein Is a Tetramer and Shares Structural and Interaction Features with Ebola Phosphoprotein VP35

Biomolecules, 2021
The human parainfluenza virus 3 (HPIV3) poses a risk for pneumonia development in young children and immunocompromised patients. To investigate mechanisms of HPIV3 pathogenesis, we characterized the association state and host protein interactions of ...
Joaquin Rodriguez Galvan, Brianna Donner, Cat Hoang Veseley, Patrick Reardon, Heather M. Forsythe, Jesse Howe, Gretchen Fujimura, Elisar Barbar   +7 more
doaj   +2 more sources

Impact of Cytokines and Phosphoproteins in Response to Chronic Joint Infection

Biology, 2020
The early cellular response to infection has been investigated extensively, generating valuable information regarding the mediators of acute infection response.
Nicole Prince, Julia A. Penatzer, Matthew J. Dietz, Jonathan W. Boyd   +3 more
doaj   +1 more source

In Situ Growth Intercalation Structure MXene@Anatase/Rutile TiO₂ Ternary Heterojunction with Excellent Phosphoprotein Detection in Sweat

Biosensors, 2022
Abnormal protein phosphorylation may relate to diseases such as Alzheimer’s, schizophrenia, and Parkinson’s. Therefore, the real-time detection of phosphoproteins in sweat was of great significance for the early knowledge, detection, and treatment of ...
Yuting Qiao, Xianrong Liu, Zhi Jia, Peng Zhang, Li Gao, Bingxin Liu, Lijuan Qiao, Lei Zhang   +7 more
doaj   +1 more source

Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment

mBio, 2019
The filoviruses are etiological agents of life-threatening hemorrhagic fever with high mortality rate and risk of potential outbreak. Among members of this family, the Ebola (EBOV), Sudan (SUDV), and Marburg (MARV) viruses are considered the most ...
Sara Landeras-Bueno, Shun-ichiro Oda, Michael J. Norris, Zhe Li Salie, Javier Guenaga, Richard T. Wyatt, Erica Ollmann Saphire   +6 more
doaj   +1 more source

Phos-tag-based phosphate affinity chromatographic techniques

Journal of Chromatography Open, 2022
For phosphoproteomics, it is important to separate and enrich phosphoproteins from complex biological samples predominantly containing their nonphosphorylated counterparts. This review describes effective chromatographic techniques for the separation and
Emiko Kinoshita-Kikuta, Eiji Kinoshita, Tohru Koike   +2 more
doaj   +1 more source

Mitogen‐Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation–Induced Cardiac Hypertrophy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe transient receptor potential vanilloid type 1 (TRPV1) is expressed in the cardiovascular system, and increased TRPV1 expression has been associated with cardiac hypertrophy.
Mai Chen, Jiajia Xin, Baohui Liu, Liyang Luo, Jiayi Li, Wen Yin, Mingkai Li   +6 more
doaj   +1 more source

The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway

Viruses, 2019
Peste des petits ruminants virus (PPRV) is associated with global peste des petits ruminants resulting in severe economic loss. Peste des petits ruminants virus dampens host interferon-based signaling pathways through multiple mechanisms.
Pengfei Li, Zixiang Zhu, Xiangle Zhang, Wen Dang, Linlin Li, Xiaoli Du, Miaotao Zhang, Chunyan Wu, Qinghong Xue, Xiangtao Liu, Haixue Zheng, Yuchen Nan   +11 more
doaj   +1 more source

Highly Sensitive Electrochemical Determination of Phosphoprotein Based on Novel 3D-CuFC-C Nano-material

Shipin gongye ke-ji
In this study, a sensitive electrochemical sensor for trace phosphoproteins monitoring in foods were developed. The sensor (NH2-TiO2/CuFC-C/GCE (TIECS)) was composed of recognition element aminated titanium dioxide (NH2-TiO2) and three-dimensional (3D ...
Jianping GUO, Jingwen WANG, Lele YUE, Mengmeng REN   +3 more
doaj   +1 more source

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues

G3: Genes, Genomes, Genetics, 2017
In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper tissue morphogenesis and organ growth.
Linda M. Parsons, Nicola A. Grzeschik, Kasun Amaratunga, Peter Burke, Leonie M. Quinn, Helena E. Richardson   +5 more
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Nipah Virus Impairs Autocrine IFN Signaling by Sequestering STAT1 and STAT2 into Inclusion Bodies

Viruses, 2023
Nipah virus (NiV) is an emerging zoonotic paramyxovirus that causes fatal infections in humans. As with most disease-causing viruses, the pathogenic potential of NiV is linked to its ability to block antiviral responses, e.g., by antagonizing IFN ...
Nico Becker, Andrea Maisner
doaj   +1 more source