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Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging
Frontiers in Immunology, 2017 Viruses assemble large macromolecular repeat structures that become part of the infectious particles or virions. Ribonucleocapsids (RNCs) of negative strand RNA viruses are a prime example where repetition of nucleoprotein (NP) along the genome creates a
Tamarand Lee Darling +3 more
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Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
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Viruses, 2012 Arenaviruses merit significant interest because several family members are etiological agents of severe hemorrhagic fevers, representing a major burden to public health.
Luis Martínez-Sobrido +3 more
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Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry [PDF]
, 2012 Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses ...
Denham, Eleanor M. +8 more
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Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex
Viruses, 2023 Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein (N) in the absence of RNA
Camilla M. Donnelly +4 more
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The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid [PDF]
, 2013 Respiratory Syncytial Virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and ...
Bhella +10 more
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Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
, 2017 Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
core +2 more sources
Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection
Viruses, 2010 Arenaviruses merit interest both as tractable experimental model systems to study acute and persistent viral infections, and as clinically-important human pathogens. Several arenaviruses cause hemorrhagic fever (HF) disease in humans.
Juan Carlos de la Torre +2 more
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Vaccines, 2023 Current seasonal influenza vaccines have suboptimal effectiveness, especially in seasons dominated by viruses that do not match the vaccine. Therefore, finding new approaches to improve the immunogenicity and efficacy of traditional influenza vaccines is
Polina Prokopenko +8 more
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RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. [PDF]
, 2015 The RAD54 family DNA translocases have several biochemical activities. One activity, demonstrated previously for the budding yeast translocases, is ATPase-dependent disruption of RAD51-dsDNA binding.
Bishop, Douglas K +8 more
core +2 more sources