Results 31 to 40 of about 55,866 (243)

THE SPANISH INFLUENZA VIRUS: TREATS TO THE PORTRAIT AFTER 100 YEARS

Инфекция и иммунитет, 2018
The purpose of the study was to compare molecular characteristics of genes and proteins of pandemic influenza strains and find features of the 1918 Spanish influenza virus.
E. P. Kharchenko
doaj   +1 more source

Construção de uma biblioteca de fragmentos de anticorpos monoclonais de galinhas com cadeia única (scFv) por phage display com reatividade cruzada para estirpes heterólogas do vírus da bronquite infecciosa aviária Construction of an avian single chain monoclonal antibodies (scFv) library by phage display that cross-reacted with heterologous avian infectious bronchitis virus strains

Ciência Rural, 2010
Anticorpos monoclonais constituem a base de vários testes usados na detecção e na identificação de antígenos. Nesse contexto, tais imuno-reagentes têm sido extensivamente empregados na identificação de estirpes virais envolvidas na etiologia de surtos de
Camila Cesário Fernandes, Aline Gonçalves Caetano, Mariana Costa Mello Gonçalves, Maria de Fátima Silva Montassier, Aliandra Maura Gibertoni, Hélio José Montassier   +5 more
doaj   +1 more source

Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses

Viruses, 2021
Influenza hemagglutinin (HA) is considered a major protective antigen of seasonal influenza vaccine but antigenic drift of HA necessitates annual immunizations using new circulating HA versions. Low variation found within conserved non-HA influenza virus
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanné Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy   +12 more
doaj   +1 more source

Radiation damage to nucleoprotein complexes in macromolecular crystallography

, 2015
Significant progress has been made in macromolecular crystallography over recent years in both the understanding and mitigation of X-ray induced radiation damage when collecting diffraction data from crystalline proteins.
Ravelli, Raimond B. G., Ravelli, Raimond B.G., Mcgeehan, John E., Bury, Charles, Kneale, Geoff, Garman, Elspeth F., Ginn, Helen Mary, Carmichael, Ian, Garman, Elspeth   +8 more
core   +1 more source

Involvement of Actin-Regulating Factor Cofilin in the Inclusion Body Formation and RNA Synthesis of Human Parainfluenza Virus Type 3 via Interaction With the Nucleoprotein

Frontiers in Microbiology, 2019
Human parainfluenza virus type 3 (HPIV3) is one of the primary pathogens that causing severe respiratory tract diseases in newborns and infants. It could induce inclusion bodies (IBs) in infected cells.
Yinshuang Li, Yinshuang Li, Chaoliang Zhang, Chaoliang Zhang, Nan Lu, Xichuan Deng, Guangchao Zang, Shengwei Zhang, Hong Tang, Guangyuan Zhang   +9 more
doaj   +1 more source

The Nucleocapsid of Paramyxoviruses: Structure and Function of an Encapsidated Template

Viruses, 2021
Viruses of the Paramyxoviridae family share a common and complex molecular machinery for transcribing and replicating their genomes. Their non-segmented, negative-strand RNA genome is encased in a tight homopolymer of viral nucleoproteins (N).
Louis-Marie Bloyet
doaj   +1 more source

Functional domains of the influenza A virus PB2 protein:identification of NP- and PB1-binding sites

, 2004
Influenza virus genomic RNA segments are packaged into ribonucleoprotein (RNP) structures by the PB1, PB2, and PA subunits of an RNA polymerase and a single-strand RNA-binding nucleoprotein (NP).
Poole, Emma, Digard, Paul, Medcalf, Liz, Elton, Debra, Poole, Emma L   +4 more
core   +1 more source

Nucleoprotein-based nanoscale assembly [PDF]

Proceedings of the National Academy of Sciences, 1997
A system for addressing in the construction of macromolecular assemblies can be based on the biospecificity of DNA (cytosine-5) methyltransferases and the capacity of these enzymes to form abortive covalent complexes at targeted 5-fluorocytosine residues in DNA.
S S, Smith, L, Niu, D J, Baker, J A, Wendel, S E, Kane, D S, Joy   +5 more
openaire   +2 more sources

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Genome encapsidation by orthobunyavirus nucleoproteins [PDF]

Proceedings of the National Academy of Sciences, 2013
All negative-sense, single-stranded RNA (−ssRNA) viruses encode a nucleoprotein (NP), the major function of which is to bind viral RNAs and encapsidate them as ribonucleoprotein complexes (RNPs) (1, 2). Consequently, the genomes of −ssRNA viruses do not exist as naked RNA but rather as protein–RNA complexes with high-order structures. In PNAS, Li et al.
Wenjie, Zheng, Yizhi Jane, Tao
openaire   +2 more sources