Results 31 to 40 of about 60,064 (253)

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

mSphere, 2018
Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic, IAVs evolve to become seasonal in the human host by acquiring adaptive mutations.
Isabel Pagani, Andrea Di Pietro, Alexandra Oteiza, Michela Ghitti, Nadir Mechti, Nadia Naffakh, Elisa Vicenzi   +6 more
doaj   +1 more source

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

mBio, 2017
Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex.
Yu-Chen Lin, King-Song Jeng, Michael M. C. Lai   +2 more
doaj   +1 more source

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]

, 2013
Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
Megan K. L. MacLeod (402779), Jieru Wang, Wang Jieru, Noges, L., Wang, J., Jin Niyun, Philippa Marrack, Laura Noges (402781), Megan K L Macleod, MacLeod Megan K. L., John W. Kappler (256540), Kappler John W., Niyun Jin (402780), Jin, N., Marrack, P., Alexandria David, Marrack Philippa, Macleod, M.K.L., Noges Laura, Kappler, J.W., Niyun Jin, John W Kappler, Philippa Marrack (26532), Alexandria David (382458), David, A., Jieru Wang (179734), David Alexandria, Laura Noges   +27 more
core   +2 more sources

THE SPANISH INFLUENZA VIRUS: TREATS TO THE PORTRAIT AFTER 100 YEARS

Инфекция и иммунитет, 2018
The purpose of the study was to compare molecular characteristics of genes and proteins of pandemic influenza strains and find features of the 1918 Spanish influenza virus.
E. P. Kharchenko
doaj   +1 more source

Truncation of NS1 Protein Enhances T Cell-Mediated Cross-Protection of a Live Attenuated Influenza Vaccine Virus Expressing Wild-Type Nucleoprotein

Vaccines, 2023
Current seasonal influenza vaccines have suboptimal effectiveness, especially in seasons dominated by viruses that do not match the vaccine. Therefore, finding new approaches to improve the immunogenicity and efficacy of traditional influenza vaccines is
Polina Prokopenko, Victoria Matyushenko, Alexandra Rak, Ekaterina Stepanova, Anna Chistyakova, Arina Goshina, Igor Kudryavtsev, Larisa Rudenko, Irina Isakova-Sivak   +8 more
doaj   +1 more source

Evolutionary Analysis of a Parrot Bornavirus 2 Detected in a Sulphur-Crested Cockatoo (Cacatua galerita) Suggests a South American Ancestor

Animals, 2023
Parrot bornavirus (PaBV) is an RNA virus that causes Proventricular Dilatation Disease (PDD), neurological disorders, and death in Psittaciformes. Its diversity in South America is poorly known. We examined a Cacatua galerita presenting neuropathies, PDD,
Ruy D. Chacón, Christian J. Sánchez-Llatas, Andrea J. Diaz Forero, Marta B. Guimarães, Sarah L. Pajuelo, Claudete S. Astolfi-Ferreira, Antonio J. Piantino Ferreira   +6 more
doaj   +1 more source

Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions [PDF]

, 2018
The co-self-assembly of proteins and nucleic acids (NAs) produces complex biomolecular machines (e.g., ribosomes and telomerases) that represent some of the most daunting targets for biomolecular design. Despite significant advances in protein and DNA or
Subramanian, Rohit H., Stahlberg, Henning, Smith, Sarah J., Tezcan, F. Akif, Baker, Timothy S., Bailey, Jake B., Chami, Mohamed, Zhang, Ling, Cardone, Giovanni, Alberstein, Robert G., Suominen, Lauri   +10 more
core   +2 more sources

Construção de uma biblioteca de fragmentos de anticorpos monoclonais de galinhas com cadeia única (scFv) por phage display com reatividade cruzada para estirpes heterólogas do vírus da bronquite infecciosa aviária Construction of an avian single chain monoclonal antibodies (scFv) library by phage display that cross-reacted with heterologous avian infectious bronchitis virus strains

Ciência Rural, 2010
Anticorpos monoclonais constituem a base de vários testes usados na detecção e na identificação de antígenos. Nesse contexto, tais imuno-reagentes têm sido extensivamente empregados na identificação de estirpes virais envolvidas na etiologia de surtos de
Camila Cesário Fernandes, Aline Gonçalves Caetano, Mariana Costa Mello Gonçalves, Maria de Fátima Silva Montassier, Aliandra Maura Gibertoni, Hélio José Montassier   +5 more
doaj   +1 more source

Involvement of Actin-Regulating Factor Cofilin in the Inclusion Body Formation and RNA Synthesis of Human Parainfluenza Virus Type 3 via Interaction With the Nucleoprotein

Frontiers in Microbiology, 2019
Human parainfluenza virus type 3 (HPIV3) is one of the primary pathogens that causing severe respiratory tract diseases in newborns and infants. It could induce inclusion bodies (IBs) in infected cells.
Yinshuang Li, Yinshuang Li, Chaoliang Zhang, Chaoliang Zhang, Nan Lu, Xichuan Deng, Guangchao Zang, Shengwei Zhang, Hong Tang, Guangyuan Zhang   +9 more
doaj   +1 more source

Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses

Viruses, 2021
Influenza hemagglutinin (HA) is considered a major protective antigen of seasonal influenza vaccine but antigenic drift of HA necessitates annual immunizations using new circulating HA versions. Low variation found within conserved non-HA influenza virus
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanné Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy   +12 more
doaj   +1 more source