Results 31 to 40 of about 61,031 (268)

Immunogenicity of a DNA-Based Sindbis Replicon Expressing Crimean–Congo Hemorrhagic Fever Virus Nucleoprotein

Vaccines, 2021
Crimean–Congo hemorrhagic fever virus (CCHFV) infrequently causes hemorrhagic fever in humans with a case fatality rate of 30%. Currently, there is neither an internationally approved antiviral drug nor a vaccine against the virus.
Thomas Tipih, Mark Heise, Felicity Jane Burt   +2 more
doaj   +1 more source

The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly

Emerging Microbes and Infections
The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface glycoproteins (GP), Gn and Gc, that are released by processing of a glycoprotein precursor complex
Anupriya Gautam, Alexandre Lalande, Maureen Ritter, Natalia Freitas, Solène Lerolle, Lola Canus, Fouzia Amirache, Vincent Lotteau, Vincent Legros, François-Loïc Cosset, Cyrille Mathieu, Bertrand Boson   +11 more
doaj   +1 more source

A Novel Terrestrial Rabies Virus Lineage Occurring in South America: Origin, Diversification, and Evidence of Contact between Wild and Domestic Cycles

Viruses, 2021
The rabies virus (RABV) is characterized by a history dominated by host shifts within and among bats and carnivores. One of the main outcomes of long-term RABV maintenance in dogs was the establishment of variants in a wide variety of mesocarnivores.
Diego A. Caraballo, Cristina Lema, Laura Novaro, Federico Gury-Dohmen, Susana Russo, Fernando J. Beltrán, Gustavo Palacios, Daniel M. Cisterna   +7 more
doaj   +1 more source

Detection of Rabies’ ribo-nucleoprotein complex using Direct Immunofluorescence Assay.

, 2023
Negative (A) and Positive (B) brain samples were fixed, analysed for the presence of the Rabies virus antigen and visualized under a fluorescence microscope (100X objective). Arrows indicate viral ribo-nucleoprotein complex.
Isabelle Conclois (17271348), Rodrigue Simonet Poueme Namegni (17271336), Laurent God-Yang (17271354), Mohamed Moctar Mouiche Mouliom (17271339), Ranyl Nguena Guefack Noumedem (17271345), Julius Awah-Ndukum (7280063), Simon Dickmu Jumbo (17271342), Jean Marc Kameni Feussom (17328445), Abel Wade (383313), Isaac Dah (17271333), Dorothée Missé (233159), Liegeois Florian (17271351)   +11 more
core   +1 more source

Periplasmic Nanobody-APEX2 Fusions Enable Facile Visualization of Ebola, Marburg, and Mĕnglà virus Nucleoproteins, Alluding to Similar Antigenic Landscapes among Marburgvirus and Dianlovirus

Viruses, 2019
We explore evolved soybean ascorbate peroxidase (APEX2) as a reporter when fused to the C-termini of llama nanobodies (single-domain antibodies, sdAb; variable domains of heavy chain-only antibodies, VHH) targeted to the E. coli periplasm.
Laura J. Sherwood, Andrew Hayhurst
doaj   +1 more source

Nucleoprotein as a Promising Antigen for Broadly Protective Influenza Vaccines

Vaccines, 2023
Annual vaccination is considered as the main preventive strategy against seasonal influenza. Due to the highly variable nature of major viral antigens, such as hemagglutinin (HA) and neuraminidase (NA), influenza vaccine strains should be regularly ...
Alexandra Rak, Irina Isakova-Sivak, Larisa Rudenko   +2 more
doaj   +1 more source

Molecular docking study of Zingiber officinale Roscoe compounds as a mumps virus nucleoprotein inhibitor

Dental Journal, 2023
Background: Mumps virus (MuV) can trigger severe infections, such as parotitis, epididymo-orchitis, and meningitis. The effectiveness of MuV vaccine administration has been proven, but current outbreaks warrant the development of antivirals against MuV ...
Viol Dhea Kharisma, Santika Lusia Utami, Wahyu Choirur Rizky, Tim Godefridus Antonius Dings, Md Emdad Ullah, Vikash Jakhmola, Alexander Patera Nugraha   +6 more
doaj   +1 more source

Obtaining a Recombinant Nucleoprotein of the Puumala Virus for Serological Diagnostics of Hemorrhagic Fever with Renal Syndrome

Проблемы особо опасных инфекций
Puumala virus (Orthohantavirus puumalaense) is one of the causative agents of hemorrhagic fever with renal syndrome (HFRS), which is widespread in the Russian Federation (RF): more than 6 thousand cases of HFRS infection are registered annually, over the
A. E. Tishin, S. A. P’yankov, E. Yu. Prudnikova, I. R. Imatdinov   +3 more
doaj   +1 more source

Structural insights on the nucleoprotein C-terminal domain of Měnglà virus

Microbiology Spectrum, 2023
Filoviruses depend on the nucleoprotein (NP) to accomplish multiple functions during the viral life cycle. NP is the most abundantly expressed viral protein in infected cells and the main component of the viral nucleocapsid.
Diego Sebastian Ferrero, Omar Tomás Gilabert, Nuria Verdaguer   +2 more
doaj   +1 more source

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]

, 2013
Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
Megan K. L. MacLeod (402779), Jieru Wang, Wang Jieru, Noges, L., Wang, J., Jin Niyun, Philippa Marrack, Laura Noges (402781), Megan K L Macleod, MacLeod Megan K. L., John W. Kappler (256540), Kappler John W., Niyun Jin (402780), Jin, N., Marrack, P., Alexandria David, Marrack Philippa, Macleod, M.K.L., Noges Laura, Kappler, J.W., Niyun Jin, John W Kappler, Philippa Marrack (26532), Alexandria David (382458), David, A., Jieru Wang (179734), David Alexandria, Laura Noges   +27 more
core   +2 more sources