Results 21 to 30 of about 61,031 (268)

Structure of schmallenberg orthobunyavirus nucleoprotein suggests a novel mechanism of genome encapsidation [PDF]

, 2013
Schmallenberg virus (SBV), a newly emerged orthobunyavirus (family <i>Bunyaviridae</i>), has spread rapidly across Europe and has caused congenital abnormalities in the offspring of cattle, sheep, and goats.
Li, P., Dong, H., Li, Ping, Elliott, Richard M, Dong, Changjiang, Dong, C., Dong, Haohao, Elliott, Richard M., Elliott, R.M.   +8 more
core   +1 more source

The Hong Kong Influenza Virus: Treats to the Portrait after 50 Years and the Future Influenza Pandemic

Эпидемиология и вакцинопрофилактика, 2020
Relevance. Of the different subtypes, H3N2 influenza virus subtype has the highest variability and pathogenicity, often dominates in epidemiological seasons and induces high mortality exceeding its rate in pandemic.
E. P. Kharchenko
doaj   +1 more source

Contribution of the Nuclear Localization Sequences of Influenza A Nucleoprotein to the Nuclear Import of the Influenza Genome in Infected Cells

Viruses, 2023
Replication of the RNA genome of influenza A virus occurs in the nucleus of infected cells. The influenza nucleoprotein (NP) associated with the viral RNA into ribonucleoprotein complexes (vRNPs) is involved in the nuclear import of the viral genome.
Nhan L. T. Nguyen, Wei Wu, Nelly Panté
doaj   +1 more source

Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-1

Frontiers in Microbiology, 2023
BackgroundTight junctions act as a barrier that prevents invasion of pathogens through epithelial cells. This study aims to elucidate the correlation between tight junctions and nairoviruses using Hazara orthonairovirus (HAZV) as a surrogate model for ...
Keisuke Ohta, Naoki Saka, Masayoshi Fukasawa, Machiko Nishio   +3 more
doaj   +1 more source

Potential antiviral peptides against the nucleoprotein of SARS-CoV-2

, 2022
Nucleoprotein is a conserved structural protein of SARS-CoV-2, which is involved in several functions, including replication, packaging, and transcription.
Kaium, Md Abdul, Mahdi, Iktedar, Halim, Mohammad A., Ali, Md. Ackas, Sufian, Md. Abu, Badhan, Raina Masnoon, Yeasmin, Humyara, Ali, Md Ackas, Kaium, Md. Abdul, Sufian, Md Abu, Hossain, Imtiaz, Islam, Rajib   +11 more
core   +1 more source

Radiation damage to nucleoprotein complexes in macromolecular crystallography [PDF]

, 2015
Significant progress has been made in macromolecular crystallography over recent years in both the understanding and mitigation of X-ray induced radiation damage when collecting diffraction data from crystalline proteins.
Ravelli, Raimond B. G., Mcgeehan, John E., Bury, Charles, Kneale, Geoff, Garman, Elspeth F., Ginn, Helen Mary, Carmichael, Ian, I. Carmichael (2645569), G. Kneale (20134014), C. Bury (20132679), R. B. G. Ravelli (20134011), H. M. Ginn (20134008), J. E. McGeehan (20132787), E. F. Garman (20115030)   +13 more
core   +1 more source

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Human Vaccines & Immunotherapeutics, 2018
Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo ...
D. Korenkov, T. H. O. Nguyen, I. Isakova-Sivak, T. Smolonogina, L. E. Brown, K. Kedzierska, L. Rudenko   +6 more
doaj   +1 more source

Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies

Frontiers in Immunology, 2017
Marburg virus (MARV) is a highly lethal hemorrhagic fever virus that is increasingly re-emerging in Africa, has been imported to both Europe and the US, and is also a Tier 1 bioterror threat.
John Anthony Garza, Alexander Bryan Taylor, Laura Jo Sherwood, Peter John Hart, Peter John Hart, Andrew Hayhurst   +5 more
doaj   +1 more source

Phenotypic Consequence of Rearranging the N Gene of RABV HEP-Flury

Viruses, 2019
Nucleoprotein (N) is a key element in rabies virus (RABV) replication. To further investigate the effect of N on RABV, we manipulated an infectious cDNA clone of the RABV HEP-Flury to rearrange the N gene from its wild-type position of 1 (N-P-M-G-L) to 2
Mingzhu Mei, Teng Long, Qiong Zhang, Jing Zhao, Qin Tian, Jiaojiao Peng, Jun Luo, He Jiang, Yingyi Lin, Zhixiong Lin, Xiaofeng Guo   +10 more
doaj   +1 more source

Impaired Nuclear Export of the Ribonucleoprotein Complex and Virus-Induced Cytotoxicity Combine to Restrict Propagation of the A/Duck/Malaysia/02/2001 (H9N2) Virus in Human Airway Cells

Cells, 2020
In humans, (A549) cells impaired H9N2 virus nuclear export of the ribonucleoprotein (RNP) complex contrasted with the early and efficient nuclear export of the H1N1/WSN and pH1N1 virus RNP complexes.
Sriram Kumar, Dawn Yeo, Nisha Harur Muralidharan, Soak Kuan Lai, Cathlyn Tong, Boon Huan Tan, Richard J. Sugrue   +6 more
doaj   +1 more source