Results 21 to 30 of about 55,866 (243)
Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions [PDF]
, 2018 The co-self-assembly of proteins and nucleic acids (NAs) produces complex biomolecular machines (e.g., ribosomes and telomerases) that represent some of the most daunting targets for biomolecular design. Despite significant advances in protein and DNA or
Subramanian, Rohit H. +10 more
core +2 more sources
Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex
Viruses, 2023 Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein (N) in the absence of RNA
Camilla M. Donnelly +4 more
doaj +1 more source
Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection
Viruses, 2010 Arenaviruses merit interest both as tractable experimental model systems to study acute and persistent viral infections, and as clinically-important human pathogens. Several arenaviruses cause hemorrhagic fever (HF) disease in humans.
Juan Carlos de la Torre +2 more
doaj +1 more source
Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]
, 2013 Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
Megan K. L. MacLeod (402779) +27 more
core +1 more source
Angewandte Chemie, EarlyView.Rationally designed DNA multivalent aptamers direct specific protein binding to drive self‐assembly into protein‐DNA frameworks (PDFs). Structurally defined protein‐aptamer interfaces organize proteins into triangles, linear and ladderlike chains, and periodic two‐dimensional arrays, enabling precise control over orientation, connectivity, and overall ...
Zhe Zhang +11 more
wiley +2 more sources
mSphere, 2018 Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic, IAVs evolve to become seasonal in the human host by acquiring adaptive mutations.
Isabel Pagani +6 more
doaj +1 more source
Vaccines, 2023 Current seasonal influenza vaccines have suboptimal effectiveness, especially in seasons dominated by viruses that do not match the vaccine. Therefore, finding new approaches to improve the immunogenicity and efficacy of traditional influenza vaccines is
Polina Prokopenko +8 more
doaj +1 more source
CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication
mBio, 2017 Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex.
Yu-Chen Lin +2 more
doaj +1 more source
Animals, 2023 Parrot bornavirus (PaBV) is an RNA virus that causes Proventricular Dilatation Disease (PDD), neurological disorders, and death in Psittaciformes. Its diversity in South America is poorly known. We examined a Cacatua galerita presenting neuropathies, PDD,
Ruy D. Chacón +6 more
doaj +1 more source
, 2013 Schmallenberg virus (SBV), a newly emerged orthobunyavirus (family <i>Bunyaviridae</i>), has spread rapidly across Europe and has caused congenital abnormalities in the offspring of cattle, sheep, and goats.
Li, P. +8 more
core +1 more source