Results 11 to 20 of about 61,031 (268)

Observation of arenavirus nucleoprotein heptamer assembly [PDF]

FEBS Open Bio, 2021
Arenaviruses are enveloped viruses containing a segmented, negative, and ambisense single‐stranded RNA genome wrapped with a nucleoprotein (NP). The NP is the most abundant viral protein in infected cells and plays a critical role in both replication ...
Nicolas Papageorgiou, Afroditi Vaitsopoulou, Awa Diop, Thi Hong Van Nguyen, Bruno Canard, Karine Alvarez, François Ferron   +6 more
doaj   +2 more sources

TRIM21 Neutralizes Hazara Virus Using a Dual Mechanism of Nucleoprotein Caging and Ubiquitination [PDF]

Viruses
Crimean–Congo Hemorrhagic Fever Virus (CCHFV) is a tick-borne bunyavirus with widespread and growing geographic distribution that causes severe hemorrhagic fever and death.
Aminu S. Jahun, Boglarka A. Vamos, Anna Albecka, Marina Vaysburd, David Hawman, Leo C. James   +5 more
doaj   +2 more sources

Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex

Viruses, 2023
Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein (N) in the absence of RNA
Camilla M. Donnelly, Murray Stewart, Justin A. Roby, Vinod Sundaramoorthy, Jade K. Forwood   +4 more
doaj   +1 more source

Truncation of NS1 Protein Enhances T Cell-Mediated Cross-Protection of a Live Attenuated Influenza Vaccine Virus Expressing Wild-Type Nucleoprotein

Vaccines, 2023
Current seasonal influenza vaccines have suboptimal effectiveness, especially in seasons dominated by viruses that do not match the vaccine. Therefore, finding new approaches to improve the immunogenicity and efficacy of traditional influenza vaccines is
Polina Prokopenko, Victoria Matyushenko, Alexandra Rak, Ekaterina Stepanova, Anna Chistyakova, Arina Goshina, Igor Kudryavtsev, Larisa Rudenko, Irina Isakova-Sivak   +8 more
doaj   +1 more source

Evolutionary Analysis of a Parrot Bornavirus 2 Detected in a Sulphur-Crested Cockatoo (Cacatua galerita) Suggests a South American Ancestor

Animals, 2023
Parrot bornavirus (PaBV) is an RNA virus that causes Proventricular Dilatation Disease (PDD), neurological disorders, and death in Psittaciformes. Its diversity in South America is poorly known. We examined a Cacatua galerita presenting neuropathies, PDD,
Ruy D. Chacón, Christian J. Sánchez-Llatas, Andrea J. Diaz Forero, Marta B. Guimarães, Sarah L. Pajuelo, Claudete S. Astolfi-Ferreira, Antonio J. Piantino Ferreira   +6 more
doaj   +1 more source

Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses

Viruses, 2021
Influenza hemagglutinin (HA) is considered a major protective antigen of seasonal influenza vaccine but antigenic drift of HA necessitates annual immunizations using new circulating HA versions. Low variation found within conserved non-HA influenza virus
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanné Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy   +12 more
doaj   +1 more source

The Nucleocapsid of Paramyxoviruses: Structure and Function of an Encapsidated Template

Viruses, 2021
Viruses of the Paramyxoviridae family share a common and complex molecular machinery for transcribing and replicating their genomes. Their non-segmented, negative-strand RNA genome is encased in a tight homopolymer of viral nucleoproteins (N).
Louis-Marie Bloyet
doaj   +1 more source

Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests

Cell Reports Medicine, 2021
Summary: The ongoing coronavirus disease 2019 (COVID-19) pandemic is a major global public health concern. Although rapid point-of-care testing for detecting viral antigen is important for management of the outbreak, the current antigen tests are less ...
Yutaro Yamaoka, Kei Miyakawa, Sundararaj Stanleyraj Jeremiah, Rikako Funabashi, Koji Okudela, Sayaka Kikuchi, Junichi Katada, Atsuhiko Wada, Toshiki Takei, Mayuko Nishi, Kohei Shimizu, Hiroki Ozawa, Shuzo Usuku, Chiharu Kawakami, Nobuko Tanaka, Takeshi Morita, Hiroyuki Hayashi, Hideaki Mitsui, Keita Suzuki, Daisuke Aizawa, Yukihiro Yoshimura, Tomoyuki Miyazaki, Etsuko Yamazaki, Tadaki Suzuki, Hirokazu Kimura, Hideaki Shimizu, Nobuhiko Okabe, Hideki Hasegawa, Akihide Ryo   +28 more
doaj   +1 more source

Structural and functional studies of novel mechanisms of Lassa fever virus nucleoprotein in immune suppression, viral RNA transcription and replication [PDF]

, 2013
Lassa fever virus is one of the most dangerous viruses of arenaviridae family, causing more than 500,000 infections per year in Africa. The fatality rate for hospitalized patients is as high as 20%.
Qi, Xiaoxuan
core   +2 more sources

Architecture of a Polycomb Nucleoprotein Complex [PDF]

Molecular Cell, 2006
Polycomb group (PcG) epigenetic silencing proteins act through cis-acting DNA sequences, named Polycomb response elements (PREs). Within PREs, Pleiohomeotic (PHO) binding sites and juxtaposed Pc binding elements (PBEs) function as an integrated DNA platform for the synergistic binding of PHO and the multisubunit Polycomb core complex (PCC).
Tielenius Kruythoff-Mohd Sarip, Adone, Van Der Knaap, Jan A., Wyman, Claire, Kanaar, Roland, Schedl, Paul, Verrijzer, C. Peter   +5 more
openaire   +3 more sources