Results 11 to 20 of about 48,568 (203)

Architecture of a Polycomb Nucleoprotein Complex [PDF]

Molecular Cell, 2006
Polycomb group (PcG) epigenetic silencing proteins act through cis-acting DNA sequences, named Polycomb response elements (PREs). Within PREs, Pleiohomeotic (PHO) binding sites and juxtaposed Pc binding elements (PBEs) function as an integrated DNA platform for the synergistic binding of PHO and the multisubunit Polycomb core complex (PCC).
Tielenius Kruythoff-Mohd Sarip, Adone, Van Der Knaap, Jan A., Wyman, Claire, Kanaar, Roland, Schedl, Paul, Verrijzer, C. Peter   +5 more
openaire   +3 more sources

Development of an Immunochromatography Assay to Detect Marburg Virus and Ravn Virus

Viruses, 2023
The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV),
Katendi Changula, Masahiro Kajihara, Shino Muramatsu, Koji Hiraoka, Toru Yamaguchi, Yoko Yago, Daisuke Kato, Hiroko Miyamoto, Akina Mori-Kajihara, Asako Shigeno, Reiko Yoshida, Corey W. Henderson, Andrea Marzi, Ayato Takada   +13 more
doaj   +1 more source

Isolation of Lagos Bat Virus from Water Mongoose

Emerging Infectious Diseases, 2006
A genotype 2 lyssavirus, Lagos bat virus (LBV), was isolated from a terrestrial wildlife species (water mongoose) in August 2004 in the Durban area of the KwaZulu-Natal Province of South Africa.
Wanda Markotter, Ivan V. Kuzmin, Charles E. Rupprecht, Jenny Randles, Claude T. Sabeta, Alexander I. Wandeler, Louis H. Nel   +6 more
doaj   +1 more source

Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging

Frontiers in Immunology, 2017
Viruses assemble large macromolecular repeat structures that become part of the infectious particles or virions. Ribonucleocapsids (RNCs) of negative strand RNA viruses are a prime example where repetition of nucleoprotein (NP) along the genome creates a
Tamarand Lee Darling, Tamarand Lee Darling, Laura Jo Sherwood, Andrew Hayhurst   +3 more
doaj   +1 more source

D471G Mutation in LCMV-NP Affects Its Ability to Self-associate and Results in a Dominant Negative Effect in Viral RNA Synthesis

Viruses, 2012
Arenaviruses merit significant interest because several family members are etiological agents of severe hemorrhagic fevers, representing a major burden to public health.
Luis Martínez-Sobrido, Juan C. de la Torre, Benson Y.H. Cheng, Emilio Ortiz-Riaño   +3 more
doaj   +1 more source

Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection

Viruses, 2010
Arenaviruses merit interest both as tractable experimental model systems to study acute and persistent viral infections, and as clinically-important human pathogens. Several arenaviruses cause hemorrhagic fever (HF) disease in humans.
Juan Carlos de la Torre, Luis Martínez-Sobrido, Persephone Borrow   +2 more
doaj   +1 more source

Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex

Viruses, 2023
Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein (N) in the absence of RNA
Camilla M. Donnelly, Murray Stewart, Justin A. Roby, Vinod Sundaramoorthy, Jade K. Forwood   +4 more
doaj   +1 more source

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

mSphere, 2018
Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic, IAVs evolve to become seasonal in the human host by acquiring adaptive mutations.
Isabel Pagani, Andrea Di Pietro, Alexandra Oteiza, Michela Ghitti, Nadir Mechti, Nadia Naffakh, Elisa Vicenzi   +6 more
doaj   +1 more source

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

mBio, 2017
Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex.
Yu-Chen Lin, King-Song Jeng, Michael M. C. Lai   +2 more
doaj   +1 more source

THE SPANISH INFLUENZA VIRUS: TREATS TO THE PORTRAIT AFTER 100 YEARS

Инфекция и иммунитет, 2018
The purpose of the study was to compare molecular characteristics of genes and proteins of pandemic influenza strains and find features of the 1918 Spanish influenza virus.
E. P. Kharchenko
doaj   +1 more source