Results 41 to 50 of about 47,998 (169)

The Replication Function of Rabies Virus P Protein Is Regulated by a Novel Phosphorylation Site in the N-Terminal N Protein-Binding Region

Viruses
The rabies virus (RABV) phosphoprotein (P protein) has multiple functions, including acting as the essential non-catalytic cofactor of the viral polymerase (L protein) for genome replication and transcription; the principal viral antagonist of the ...
Ericka Tudhope, Camilla M. Donnelly, Ashish Sethi, Cassandra David, Nicholas Williamson, Murray Stewart, Jade K. Forwood, Paul R. Gooley, Gregory W. Moseley   +8 more
doaj   +1 more source

Phenotypic Consequence of Rearranging the N Gene of RABV HEP-Flury

Viruses, 2019
Nucleoprotein (N) is a key element in rabies virus (RABV) replication. To further investigate the effect of N on RABV, we manipulated an infectious cDNA clone of the RABV HEP-Flury to rearrange the N gene from its wild-type position of 1 (N-P-M-G-L) to 2
Mingzhu Mei, Teng Long, Qiong Zhang, Jing Zhao, Qin Tian, Jiaojiao Peng, Jun Luo, He Jiang, Yingyi Lin, Zhixiong Lin, Xiaofeng Guo   +10 more
doaj   +1 more source

The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly

Emerging Microbes and Infections
The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface glycoproteins (GP), Gn and Gc, that are released by processing of a glycoprotein precursor complex
Anupriya Gautam, Alexandre Lalande, Maureen Ritter, Natalia Freitas, Solène Lerolle, Lola Canus, Fouzia Amirache, Vincent Lotteau, Vincent Legros, François-Loïc Cosset, Cyrille Mathieu, Bertrand Boson   +11 more
doaj   +1 more source

Periplasmic Nanobody-APEX2 Fusions Enable Facile Visualization of Ebola, Marburg, and Mĕnglà virus Nucleoproteins, Alluding to Similar Antigenic Landscapes among Marburgvirus and Dianlovirus

Viruses, 2019
We explore evolved soybean ascorbate peroxidase (APEX2) as a reporter when fused to the C-termini of llama nanobodies (single-domain antibodies, sdAb; variable domains of heavy chain-only antibodies, VHH) targeted to the E. coli periplasm.
Laura J. Sherwood, Andrew Hayhurst
doaj   +1 more source

Obtaining a Recombinant Nucleoprotein of the Puumala Virus for Serological Diagnostics of Hemorrhagic Fever with Renal Syndrome

Проблемы особо опасных инфекций
Puumala virus (Orthohantavirus puumalaense) is one of the causative agents of hemorrhagic fever with renal syndrome (HFRS), which is widespread in the Russian Federation (RF): more than 6 thousand cases of HFRS infection are registered annually, over the
A. E. Tishin, S. A. P’yankov, E. Yu. Prudnikova, I. R. Imatdinov   +3 more
doaj   +1 more source

To be or not to be phosphorylated: understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2A-B56

Emerging Microbes and Infections
Ebola virus (EBOV) transcription is essentially regulated via dynamic dephosphorylation of its viral transcription activator VP30 by the host phosphatase PP2A.
Lennart Kämper, Ida Kuhl, Melina Vallbracht, Thomas Hoenen, Uwe Linne, Axel Weber, Petr Chlanda, Michael Kracht, Nadine Biedenkopf   +8 more
doaj   +1 more source

Synthetic DNA co-immunization with vaccine-aligned common consensus nucleoprotein and hemagglutinin protects mice against lethal influenza infection with a single immunization

Frontiers in Immunology
IntroductionThere is an urgent need for influenza vaccine strategies that enhance protection against influenza virus drift and across different subtypes. The conserved viral nucleoprotein (NP) is the most abundant viral protein during replication, and a
Ebony N. Gary, Abigail R. Trachtman, Dan Wang, Suman Bharti, Ying Ye, Nicholas J. Tursi, Nicholas J. Tursi, Martina Tomirotti, Martina Tomirotti, Jillian Eisenhauer, Jillian Eisenhauer, Jacqueline D. Chu, David Custodio Zegarra, Casey E. Hojecki, Micki Zheng, Micki Zheng, Jayamanna Wickramasinghe, David B. Weiner, Ami Patel   +18 more
doaj   +1 more source

MiR-130c-5p targets the SHVV n gene and upregulates immune cytokines (IL-6, IL-22, IL-1β) to inhibit viral replication

Frontiers in Immunology
BackgroundSnakehead vesiculovirus (SHVV) has led to huge economic losses in snakehead aquaculture, and its pathogenic mechanisms is still not fully understood.
Jin Wei, Yan Ji, Yaqian Bai, Rui Cheng, Jiaqi Zhang, Xianqin Hu, Chi Zhang   +6 more
doaj   +1 more source

Structural disorder within paramyxoviral nucleoproteins

FEBS Letters, 2015
In this review I summarize available data pointing to the abundance of structural disorder within the nucleoprotein (N) from three paramyxoviruses, namely the measles (MeV), Nipah (NiV) and Hendra (HeV) viruses. I provide a detailed description of the molecular mechanisms that govern the disorder‐to‐order transition that the intrinsically disordered C ...
openaire   +4 more sources

Study on the immune enhancers against Micropterus salmoides rhabdovirus infection

Journal of Limnology
Micropterus salmoides rhabdovirus (MSRV) is one of the most serious pathogens harming M. salmoides juvenile, which had brought huge economic losses to farming industry. Studies involving candidate genes to the clinical diseases, however, are limited. In
Ning Lei, Chaonan Zhang, Yanchao Wang, Junjie Zhu   +3 more
doaj   +1 more source