Results 41 to 50 of about 61,031 (268)

Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection

Viruses, 2023
Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause significant
Morgan R. Jennings, Robin J. Parks
doaj   +1 more source

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro

mBio, 2020
Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which concentrate all the proteins of the polymerase complex as well as some cellular ...
Marie Galloux, Jennifer Risso-Ballester, Charles-Adrien Richard, Jenna Fix, Marie-Anne Rameix-Welti, Jean-François Eléouët   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

To be or not to be phosphorylated: understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2A-B56

Emerging Microbes and Infections
Ebola virus (EBOV) transcription is essentially regulated via dynamic dephosphorylation of its viral transcription activator VP30 by the host phosphatase PP2A.
Lennart Kämper, Ida Kuhl, Melina Vallbracht, Thomas Hoenen, Uwe Linne, Axel Weber, Petr Chlanda, Michael Kracht, Nadine Biedenkopf   +8 more
doaj   +1 more source

A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants

Viruses, 2020
The emergence of resistance to currently available anti-influenza drugs has heightened the need for antivirals with novel mechanisms of action. The influenza A virus (IAV) nucleoprotein (NP) is highly conserved and essential for the formation of viral ...
Juliann Nzembi Makau, Ken Watanabe, Hiroki Otaki, Satoshi Mizuta, Takeshi Ishikawa, Yuji O. Kamatari, Noriyuki Nishida   +6 more
doaj   +1 more source

The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes.

, 2016
The nucleoprotein of negative-strand RNA viruses forms a major component of the ribonucleoprotein complex that is responsible for viral transcription and replication.

core   +1 more source

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]

, 2010
Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Dubuquoy, Catherine, C., Eléouët, Jean-François, Soulestin, Marion, Deville, Sébastien, Durand, Guillaume, Meyer, Gilles, G., Bernard, Julie, Bernadet, Philippe, Bernardet, Philippe, Petit-Camurdan, Agnès, Schwartz-Cornil, Isabelle, Riffault, Sabine, Dubosclard, Virginie, Eleouet, Jean Francois, J. F., Meyer, Gilles, Castagné, Nathalie, Deplanche, Martine, Bernex, Florence, Dubuquoy, Catherine, Martine Deplanche, Catherine Dubuquoy, Gilles Meyer, Julie Bernard, Sébastien Deville, Eleouet, Jean Francois,, Philippe Bernardet, Florence Bernex, Sabine Riffault, Nathalie Castagné, Virginie Dubosclard, Isabelle Schwartz-Cornil, Dubuquoy, Catherine,, Agnès Petit-Camurdan, Jean-François Eléouët, Marion Soulestin, Guillaume Durand, Meyer, Gilles,   +36 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Synthetic DNA co-immunization with vaccine-aligned common consensus nucleoprotein and hemagglutinin protects mice against lethal influenza infection with a single immunization

Frontiers in Immunology
IntroductionThere is an urgent need for influenza vaccine strategies that enhance protection against influenza virus drift and across different subtypes. The conserved viral nucleoprotein (NP) is the most abundant viral protein during replication, and a
Ebony N. Gary, Abigail R. Trachtman, Dan Wang, Suman Bharti, Ying Ye, Nicholas J. Tursi, Nicholas J. Tursi, Martina Tomirotti, Martina Tomirotti, Jillian Eisenhauer, Jillian Eisenhauer, Jacqueline D. Chu, David Custodio Zegarra, Casey E. Hojecki, Micki Zheng, Micki Zheng, Jayamanna Wickramasinghe, David B. Weiner, Ami Patel   +18 more
doaj   +1 more source

The Nucleoprotein and Phosphoprotein of Measles Virus [PDF]

Frontiers in Microbiology, 2019
Measles virus is a negative strand virus and the genomic and antigenomic RNA binds to the nucleoprotein (N), assembling into a helical nucleocapsid. The polymerase complex comprises two proteins, the Large protein (L), that both polymerizes RNA and caps the mRNA, and the phosphoprotein (P) that co-localizes with L on the nucleocapsid.
Guseva, Serafima, Milles, Sigrid, Blackledge, Martin, Ruigrok, Rob W H   +3 more
openaire   +5 more sources