Correlates of Immunity to Filovirus Infection
Viruses, 2011 Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections.
Sina Bavari +2 more
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Marburg and Sudan virus outbreaks: are we any closer to a pan-filovirus vaccine? [PDF]
Tropical Diseases, Travel Medicine and VaccinesFiloviruses, including Ebola, Marburg, and Sudan viruses, cause severe hemorrhagic fevers with high mortality rates and outbreaks. While recent vaccine developments such as the rVSV-ZEBOV vaccine for Ebola have marked important progress and is now ...
Adewunmi Akingbola +6 more
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Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification [PDF]
Nature CommunicationsFiloviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee +13 more
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Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress [PDF]
VirusesFiloviruses, including Ebola (EBOV) and Marburg (MARV) viruses, are zoonotic pathogens that cause severe hemorrhagic fever in humans, with mortality rates reaching up to 90%.
Loveleena K. Anand +4 more
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Standardization of the Filovirus Plaque Assay for Use in Preclinical Studies
Viruses, 2012 The filovirus plaque assay serves as the assay of choice to measure infectious virus in a cell culture, blood, or homogenized tissue sample. It has been in use for more than 30 years and is the generally accepted assay used to titrate virus in samples ...
Anthony Griffiths +2 more
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Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids [PDF]
Marine DrugsFiloviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Leah Liu Wang +6 more
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New reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs [PDF]
Frontiers in ChemistryEbola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective ...
W. Tamilarasi, B. J. Balamurugan
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Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats
Viruses, 2023 Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse +5 more
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A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates. [PDF]
PLoS ONE, 2018 The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections.
Benoit Callendret +20 more
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Acta Pharmaceutica Sinica B, 2018 Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which
Qing Chen +4 more
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