Correlates of Immunity to Filovirus Infection
Viruses, 2011 Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections.
Sina Bavari, Steven Bradfute
exaly +6 more sources
Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress [PDF]
VirusesFiloviruses, including Ebola (EBOV) and Marburg (MARV) viruses, are zoonotic pathogens that cause severe hemorrhagic fever in humans, with mortality rates reaching up to 90%.
Loveleena K. Anand +4 more
doaj +3 more sources
Filovirus Tropism: Cellular Molecules for Viral Entry [PDF]
Frontiers in Microbiology, 2012 In human and nonhuman primates, filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever．Recently, other animals such as pigs and some species of fruit bats have also been shown to be susceptible to these viruses. While having a preference
Ayato Takada
exaly +4 more sources
Persistence and Organ Tropism of Filoviruses in Farmed European Perch (Perca fluviatilis) [PDF]
J Fish DisJournal of Fish Diseases, Volume 49, Issue 5, May 2026.
Johanna Perschthaler +4 more
wiley +2 more sources
Marburg and Sudan virus outbreaks: are we any closer to a pan-filovirus vaccine? [PDF]
Tropical Diseases, Travel Medicine and VaccinesFiloviruses, including Ebola, Marburg, and Sudan viruses, cause severe hemorrhagic fevers with high mortality rates and outbreaks. While recent vaccine developments such as the rVSV-ZEBOV vaccine for Ebola have marked important progress and is now ...
Adewunmi Akingbola +6 more
doaj +2 more sources
Standardization of the Filovirus Plaque Assay for Use in Preclinical Studies
Viruses, 2012 The filovirus plaque assay serves as the assay of choice to measure infectious virus in a cell culture, blood, or homogenized tissue sample. It has been in use for more than 30 years and is the generally accepted assay used to titrate virus in samples ...
Anthony Griffiths +2 more
exaly +3 more sources
Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification [PDF]
Nature CommunicationsFiloviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee +13 more
doaj +2 more sources
Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems [PDF]
Advanced Science, Volume 13, Issue 39, 13 July 2026.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +2 more sources
Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir
Viruses, 2019 The 2014 Ebolavirus outbreak in West Africa highlighted the need for vaccines and therapeutics to prevent and treat filovirus infections. A well-characterized small animal model that is susceptible to wild-type filoviruses would facilitate the screening ...
Jason Comer +2 more
exaly +3 more sources
Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats
Viruses, 2023 Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse +5 more
doaj +1 more source