Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses [PDF]
Viruses, 2017 The mononegaviral family Filoviridae has eight members assigned to three genera and seven species. Until now, genus and species demarcation were based on arbitrarily chosen filovirus genome sequence divergence values (≈50% for genera, ≈30% for species ...
Yīmíng Bào +22 more
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Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]
eLife, 2015 Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Melinda Ng +20 more
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Filoviruses are ancient and integrated into mammalian genomes [PDF]
BMC Evolutionary Biology, 2010 Background Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine.
Bruenn Jeremy +2 more
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Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor [PDF]
Viruses, 2012 We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Esther Ndungo +7 more
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Presence and Persistence of Ebola or Marburg Virus in Patients and Survivors: A Rapid Systematic Review. [PDF]
PLoS Neglected Tropical Diseases, 2016 BackgroundThe 2013-15 Ebola outbreak was unprecedented due to sustained transmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance about
Julii Brainard +4 more
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Marburg and Sudan virus outbreaks: are we any closer to a pan-filovirus vaccine? [PDF]
Tropical Diseases, Travel Medicine and VaccinesFiloviruses, including Ebola, Marburg, and Sudan viruses, cause severe hemorrhagic fevers with high mortality rates and outbreaks. While recent vaccine developments such as the rVSV-ZEBOV vaccine for Ebola have marked important progress and is now ...
Adewunmi Akingbola +6 more
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Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification [PDF]
Nature CommunicationsFiloviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee +13 more
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Correlates of Immunity to Filovirus Infection
Viruses, 2011 Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections.
Sina Bavari, Steven B Bradfute
exaly +3 more sources
A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses [PDF]
Microbiology SpectrumFiloviruses are some of the most lethal viruses in the modern world, and increasing numbers of filovirus species and genera have been discovered in recent years.
Na Cui +7 more
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Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress [PDF]
VirusesFiloviruses, including Ebola (EBOV) and Marburg (MARV) viruses, are zoonotic pathogens that cause severe hemorrhagic fever in humans, with mortality rates reaching up to 90%.
Loveleena K. Anand +4 more
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