Correlates of Immunity to Filovirus Infection
Viruses, 2011 Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections.
Sina Bavari, Steven B Bradfute
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Clinical Management of Filovirus-Infected Patients
Viruses, 2012 Filovirus infection presents many unique challenges to patient management. Currently no approved treatments are available, and the recommendations for supportive care are not evidence based.
Peter B. Jahrling, Danielle V Clark
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Marburg and Sudan virus outbreaks: are we any closer to a pan-filovirus vaccine? [PDF]
Tropical Diseases, Travel Medicine and VaccinesFiloviruses, including Ebola, Marburg, and Sudan viruses, cause severe hemorrhagic fevers with high mortality rates and outbreaks. While recent vaccine developments such as the rVSV-ZEBOV vaccine for Ebola have marked important progress and is now ...
Adewunmi Akingbola +6 more
doaj +5 more sources
Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress [PDF]
VirusesFiloviruses, including Ebola (EBOV) and Marburg (MARV) viruses, are zoonotic pathogens that cause severe hemorrhagic fever in humans, with mortality rates reaching up to 90%.
Loveleena K. Anand +4 more
doaj +3 more sources
Undiscovered Bat Hosts of Filoviruses
PLoS Neglected Tropical Diseases, 2016 Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high ...
John Paul Schmidt +2 more
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A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses.
Microbiology SpectrumFiloviruses are some of the most lethal viruses in the modern world, and increasing numbers of filovirus species and genera have been discovered in recent years.
Hong Xie, Adam J Hume, Margaret G Mills
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Lethal Sudan virus infection in IFNAR-/- mice is characterized by key inflammatory features of filovirus disease. [PDF]
PLoS ONESudan virus (SUDV) is a member of the family Filoviridae, which comprises highly pathogenic viruses associated with unusually high case fatality rates.
Michelle Gellhorn Serra +9 more
doaj +2 more sources
Standardization of the Filovirus Plaque Assay for Use in Preclinical Studies
Viruses, 2012 The filovirus plaque assay serves as the assay of choice to measure infectious virus in a cell culture, blood, or homogenized tissue sample. It has been in use for more than 30 years and is the generally accepted assay used to titrate virus in samples ...
Anthony Griffiths +2 more
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Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification [PDF]
Nature CommunicationsFiloviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee +13 more
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Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats
Viruses, 2023 Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse +5 more
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