Results 1 to 10 of about 67,833 (224)

Development of an EBOV MiniG plus system as an advanced tool for anti-Ebola virus drug screening

Heliyon, 2023
The incidence of zoonotic diseases, such as coronavirus disease 2019 and Ebola virus disease, is increasing worldwide. However, drug and vaccine development for zoonotic diseases has been hampered because the experiments involving live viruses are ...
Chi-Ju Hsu, Cheng-Hsiu Chen, Wen-Ting Chen, Ping-Cheng Liu, Tein-Yao Chang, Meng-He Lin, Cheng-Cheung Chen, Hsing-Yu Chen, Chih-Heng Huang, Yun-Hsiang Cheng, Jun-Ren Sun   +10 more
doaj   +1 more source

Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries

Trials, 2021
Introduction The Ebola virus disease (EVD) outbreak in 2014–2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine.
Moses Badio, Edouard Lhomme, Mark Kieh, Abdoul Habib Beavogui, Stephen B. Kennedy, Seydou Doumbia, Bailah Leigh, Samba O. Sow, Alpha Diallo, Daniela Fusco, Matthew Kirchoff, Monique Termote, Renaud Vatrinet, Deborah Wentworth, Helène Esperou, H. Clifford Lane, Jerome Pierson, Deborah Watson-Jones, Céline Roy, Eric D’Ortenzio, Brian Greenwood, Genevieve Chêne, Laura Richert, James D. Neaton, Yazdan Yazdanpanah, the PREVAC study team   +25 more
doaj   +1 more source

What did we learn from preparing for cross-border transmission of Ebola virus disease into a complex humanitarian setting – The Republic of South Sudan?

Infectious Diseases of Poverty, 2020
Background Following the West Africa Ebola virus disease (EVD) outbreak (2013–2016), WHO developed a preparedness checklist for its member states. This checklist is currently being applied for the first time on a large and systematic scale to prepare for
Olushayo Oluseun Olu, Richard Lako, Joseph Francis Wamala, Patrick Otim Ramadan, Caroline Ryan, Ifeanyi Udenweze, Kibebu Berta, Argata Guracha Guyo, Alex Sokemawu, Michael Tukuru, Henry John Gray, Alex Chimbaru   +11 more
doaj   +1 more source

Care and COVID 19: Lessons for liberals and neoliberals

Child &Family Social Work, EarlyView., 2023
Abstract Within the liberal political traditions, care is regarded as a private matter, a problem of ethics rather than justice. Social justice is framed as an issue of economics (re/distribution), culture (recognition) and/or politics (representation).
Kathleen Lynch
wiley   +1 more source

TIM-1 Augments Cellular Entry of Ebola Virus Species and Mutants, Which Is Blocked by Recombinant TIM-1 Protein

Microbiology Spectrum, 2022
Ebola virus, a member of the Filoviridae family, utilizes the attachment factors on host cells to support its entry and cause severe tissue damage. TIM-1 has been identified as a predominant attachment factor via interaction with phosphatidylserine (PS ...
Min Zhang, Xinwei Wang, Linhan Hu, Yuting Zhang, Hang Zheng, Haiyan Wu, Jing Wang, Longlong Luo, He Xiao, Chunxia Qiao, Xinying Li, Weijin Huang, Youchun Wang, Jiannan Feng, Guojiang Chen   +14 more
doaj   +1 more source

Adult and paediatric haematology and clinical chemistry laboratory reference limits for Liberia

African Journal of Laboratory Medicine, 2020
Background: As more research is conducted in Liberia, there is a need for laboratory reference limits for common chemistry and haematology values based on a healthy population. Reference limits from the United States may not be applicable.
Mark W. Kieh, Sarah M. Browne, Greg A. Grandits, Julie Blie, Jestina W. Doe-Anderson, Marie L. Hoover, Bionca Davis, Cavan S. Reilly, James D. Neaton, H. Clifford Lane, Stephen B. Kennedy   +10 more
doaj   +1 more source

Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination

Emerging Microbes and Infections, 2023
Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-
Markus H. Kainulainen, Jessica R. Harmon, Amy N. Whitesell, Éric Bergeron, Elif Karaaslan, Caitlin M. Cossaboom, Jason H. Malenfant, Aaron Kofman, Joel M. Montgomery, Mary J. Choi, César G. Albariño, Christina F. Spiropoulou   +11 more
doaj   +1 more source

The laboratory health system and its response to the Ebola virus disease outbreak in Liberia

African Journal of Laboratory Medicine, 2016
The laboratory system in Liberia has generally been fragmented and uncoordinatedAccordingly, the country’s Ministry of Health established the National Reference Laboratoryto strengthen and sustain laboratory services. However, diagnostic testing services
Stephen B. Kennedy, Christine L. Wasunna, John B. Dogba, Philip Sahr, Candace B. Eastman, Fatorma K. Bolay, Gloria T. Mason, Mark W.S. Kieh   +7 more
doaj   +1 more source

A review of strategies used to retain participants in clinical research during an infectious disease outbreak: The PREVAIL I Ebola vaccine trial experience

Contemporary Clinical Trials Communications, 2018
Introduction: This article describes a retrospective review of participant follow-up and retention strategies in the Partnership for Research on the Ebola Virus in Liberia (PREVAIL) I Vaccine Trial.
Sarah Browne, Tarweh Carter, Risa Eckes, Greg Grandits, Melvin Johnson, Irene Moore, Laura McNay   +6 more
doaj   +1 more source

Comparison of Aerosol Stability of Different Variants of Ebola Virus and Marburg Virus and Virulence of Aerosolised Ebola Virus in an Immune-Deficient Mouse

Viruses, 2022
During outbreaks of virus diseases, many variants may appear, some of which may be of concern. Stability in an aerosol of several Ebola virus and Marburg virus variants was investigated.
Sophie J. Smither, Lin S. Eastaugh, Mark S. Lever   +2 more
doaj   +1 more source